公开(公告)号：WO2007011412A2

公开(公告)日：2007-01-25

申请号：PCT/US2005/040196

申请日：2005-11-07

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY ,  AGAN, Brian, K. ,  HANSON, Eric, H. ,  JENKINS, Michael, J ,  LIN, Baochuan ,  OLSEN, Chris, C. ,  ROWLEY, Robb, K. ,  STENGER, David, A. ,  THACH, Dzung, C. ,  TIBBETTS, Clark, J. ,  WALTER, Elizabeth, A. ,  LIU, Jinny, Lin

Inventor： AGAN, Brian, K. ,  HANSON, Eric, H. ,  JENKINS, Michael, J ,  LIN, Baochuan ,  OLSEN, Chris, C. ,  ROWLEY, Robb, K. ,  STENGER, David, A. ,  THACH, Dzung, C. ,  TIBBETTS, Clark, J. ,  WALTER, Elizabeth, A. ,  LIU, Jinny, Lin

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/158

Abstract: The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.

Abstract translation: 本发明提供了一组来自外周血白细胞的特定基因表达标记，其指示宿主对暴露，应答和恢复传染性病原体感染的应答。 本发明进一步提供了鉴定特定组基因表达标记物的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发作的方法，以及诊断感染性病原体感染的方法和鉴定 涉及病原体。

公开(公告)号：WO2007011412A3

公开(公告)日：2007-10-11

申请号：PCT/US2005040196

申请日：2005-11-07

Applicant: US GOV SEC NAVY ,  AGAN BRIAN K ,  HANSON ERIC H ,  JENKINS MICHAEL J ,  LIN BAOCHUAN ,  OLSEN CHRIS C ,  ROWLEY ROBB K ,  STENGER DAVID A ,  THACH DZUNG C ,  TIBBETTS CLARK J ,  WALTER ELIZABETH A ,  LIU JINNY LIN

Inventor： AGAN BRIAN K ,  HANSON ERIC H ,  JENKINS MICHAEL J ,  LIN BAOCHUAN ,  OLSEN CHRIS C ,  ROWLEY ROBB K ,  STENGER DAVID A ,  THACH DZUNG C ,  TIBBETTS CLARK J ,  WALTER ELIZABETH A ,  LIU JINNY LIN

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/158

Abstract: The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.

Abstract translation: 本发明提供了一组来自外周血白细胞的特定基因表达标记，其指示宿主对暴露，应答和恢复传染性病原体感染的应答。 本发明进一步提供了鉴定特定组基因表达标记物的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发作的方法，以及诊断感染性病原体感染的方法和鉴定 涉及病原体。

公开(公告)号：WO2007011412A9

公开(公告)日：2007-07-26

申请号：PCT/US2005040196

申请日：2005-11-07

Applicant: US GOV SEC NAVY ,  AGAN BRIAN K ,  HANSON ERIC H ,  JENKINS MICHAEL J ,  LIN BAOCHUAN ,  OLSEN CHRIS C ,  ROWLEY ROBB K ,  STENGER DAVID A ,  THACH DZUNG C ,  TIBBETTS CLARK J ,  WALTER ELIZABETH A ,  LIU JINNY LIN

Inventor： AGAN BRIAN K ,  HANSON ERIC H ,  JENKINS MICHAEL J ,  LIN BAOCHUAN ,  OLSEN CHRIS C ,  ROWLEY ROBB K ,  STENGER DAVID A ,  THACH DZUNG C ,  TIBBETTS CLARK J ,  WALTER ELIZABETH A ,  LIU JINNY LIN

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/158

Abstract: The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.

Abstract translation: 本发明提供来自外周血白细胞的特异性基因表达标志物，其指示宿主对暴露，应答和恢复感染性病原体感染的反应。 本发明还提供了用于鉴定特定基因表达标志物组的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发病的方法，诊断感染性病原体感染的方法以及鉴定 涉及病原体。