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    DISPOSABLE FOR ANALYZING A LIQUID SAMPLE BY NUCLEIC ACID AMPLIFICATION
    1.
    发明申请
    DISPOSABLE FOR ANALYZING A LIQUID SAMPLE BY NUCLEIC ACID AMPLIFICATION 审中-公开
    用于通过核酸扩增分析液体样品

    公开(公告)号：WO2008006501A8

    公开(公告)日：2008-05-29

    申请号：PCT/EP2007005952

    申请日：2007-07-05

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  SAROFIM EMAD

    Inventor： SAROFIM EMAD

    IPC: B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/0275 ,  B01L3/502707 ,  B01L7/52 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/087

    Abstract: The invention refers to a disposable sample holding and processing device (1) dimensioned for use in an apparatus for analyzing a liquid sample by nucleic acid amplification, especially the polymerase chain reaction technique, comprising a device body (2) having a structured surface and a sealing cover (4) which covers the structured surface thereby forming a wall of an amplification chamber (5) for performing nucleic acid amplification, and a wall of an inlet channel (6) connected to the amplification chamber (5) for providing the amplification chamber (5) with liquid. According to the invention the device body (2) comprises a sheet (20) on which the structured surface forming the inlet channel (6) is arranged, and that, the sheet (20) carries at least one rib for increasing the stiffness of the device body (2).

    Abstract translation: 本发明涉及一种一次性样品保持和处理装置（1），其尺寸适用于通过核酸扩增，特别是聚合酶链反应技术分析液体样品的装置，其包括具有结构化表面的装置主体（2）和 密封盖（4），其覆盖结构化表面，从而形成用于进行核酸扩增的扩增室（5）的壁，以及连接到扩增室（5）的入口通道（6）的壁，用于提供放大室 （5）用液体。 根据本发明，装置主体（2）包括一个片（20），其上形成有形成入口通道（6）的结构化表面，并且片（20）承载至少一个肋，以增加 装置主体（2）。

    DEVICE WITH A COMPRESSIBLE MATRIX HAVING A HOMOGENEOUS FLOW PROFILE
    2.
    发明申请
    DEVICE WITH A COMPRESSIBLE MATRIX HAVING A HOMOGENEOUS FLOW PROFILE 审中-公开
    具有均匀流动剖面的可压矩阵的装置

    公开(公告)号：WO2007028569A1

    公开(公告)日：2007-03-15

    申请号：PCT/EP2006/008629

    申请日：2006-09-05

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F.HOFFMANN-LA ROCHE AG ,  SAROFIM, Emad

    Inventor： SAROFIM, Emad

    IPC: G01N33/49 ,  B01L3/00 ,  B01D29/01 ,  B01D63/08 ,  B01D69/00 ,  H01M8/24

    CPC classification number: B01L3/502707 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2300/0861 ,  B01L2400/082 ,  G01N33/491

    Abstract: A fluidic device containing a flow through chamber comprising an inlet port, an outlet port, and a fluid permeable, compressible matrix located in the chamber between said inlet port and said outlet port, and said compressible matrix having a higher flow resistance at higher compressions and a plurality of flow paths leading from said inlet port to said outlet port through said matrix comprising shorter and longer length flow paths, wherein said matrix is compressed in at least one dimension, being more strongly compressed along the shorter length flow paths than along the longer length flow path.

    Abstract translation: 一种流体装置，其包含流通室，其包括位于所述入口端口和所述出口端口之间的腔室中的入口端口，出口端口和流体可渗透的可压缩基体，并且所述可压缩基体在较高压缩时具有较高的流动阻力， 从所述入口通过所述入口通过所述基体的多个流动路径，其包括较短和较长长度的流动路径，其中所述基体在至少一个维度上被压缩，沿着较短长度的流动路径比沿着较长长度的流动路径被更强地压缩 长度流路。

    SYSTEM FOR THERMOCYCLING OF FLUIDS IN CARTRIDGES
    4.
    发明申请
    SYSTEM FOR THERMOCYCLING OF FLUIDS IN CARTRIDGES 审中-公开
    液体流化床系统

    公开(公告)号：WO0117683A3

    公开(公告)日：2002-02-28

    申请号：PCT/EP0008587

    申请日：2000-09-02

    Applicant: HOFFMANN LA ROCHE ,  SCHNELL URBAN ,  ELSENHANS OLIVIER ,  CARATSCH THOMAS ,  BIRRER LUKAS ,  SAROFIM EMAD

    Inventor： SCHNELL URBAN ,  ELSENHANS OLIVIER ,  CARATSCH THOMAS ,  BIRRER LUKAS ,  SAROFIM EMAD

    IPC: G01N21/64 ,  B01L7/00 ,  C12M1/00 ,  G01N21/05 ,  G01N21/15 ,  G01N35/00

    CPC classification number: B01L7/52 ,  G01N2035/00366

    Abstract: System for thermocycling of fluids in cartridges comprising a thermocycling unit in thermal contact with a first substantially planar and heat conducting wall of a cartridge, a light source for transmitting light into the interior of said cartridge through a second light transparent wall of said cartridge which is arranged substantially perpendicular to said first wall, a light detector for detecting light emerging from the interior of the cartridge through said second wall and a fluid providing unit coupled to an inlet of the cartridge for providing the cartridge with fluid and an outlet of the cartridge to drain gas when the cartridge is filled with fluid. The invention further concerns a cartridge for conducting the thermal cycling of fluids.

    Abstract translation: 包括与筒的第一基本上平面和导热壁热接触的热循环单元的热循环系统，用于通过所述盒的第二透光壁将光透射到所述盒的内部的光源， 基本上垂直于所述第一壁布置的光检测器，用于检测通过所述第二壁从所述盒的内部出射的光的光检测器;以及耦合到所述盒的入口的流体供应单元，用于向所述盒提供所述盒的流体和出口， 当墨盒充满流体时，排出气体。 本发明还涉及用于进行流体热循环的筒。

    DISPOSABLE DEVICE FOR ANALYZING A LIQUID SAMPLE CONTAINING A NUCLEIC ACID WITH A NUCLEIC ACID AMPLIFICATION APPARATUS
    5.
    发明申请
    DISPOSABLE DEVICE FOR ANALYZING A LIQUID SAMPLE CONTAINING A NUCLEIC ACID WITH A NUCLEIC ACID AMPLIFICATION APPARATUS 审中-公开
    用于分析含有核酸放大装置的含有核酸的液体样品的可替换装置

    公开(公告)号：WO2008006502A1

    公开(公告)日：2008-01-17

    申请号：PCT/EP2007/005953

    申请日：2007-07-05

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  SAROFIM, Emad ,  KOPP, Martin ,  ELSENHANS, Olivier ,  WAHL, Hans-Peter

    Inventor： SAROFIM, Emad ,  KOPP, Martin ,  ELSENHANS, Olivier ,  WAHL, Hans-Peter

    IPC: C12Q1/68 ,  B01L3/00

    CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L2200/10 ,  B01L2300/0809

    Abstract: The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.

    Abstract translation: 本发明涉及一种一次性样品保持和处理装置（1），其尺寸适于在用于通过核酸扩增技术分析含有核酸的液体样品的核酸扩增装置中操作。 设备（1）包括设计成执行在装置（1）内捕获，扩增和检测核酸以及任选还有裂解室（3）的步骤的室（15,16）和通道（44）。 装订室（15）包含用于固定待分析样品的组分的固相（14），并且扩散室（16）通过流体通道（44）连接到装订室（15）。 装置（1）包括刚体（42）和至少一个通道（44），装订室（15）和放大室（16）位于主体（42）的侧表面（50）上， 其中通道（44），装订室（15）或放大室（16）所在的那些侧表面（50）中的每一个被至少一个壁（41）和这些侧表面 50）在装置（1）在核酸扩增装置中操作时是基本垂直的平面。

    APPARATUS FOR PERFORMING NUCLEIC ACID ANALYSIS
    6.
    发明申请
    APPARATUS FOR PERFORMING NUCLEIC ACID ANALYSIS 审中-公开
    用于实施核酸分析的装置

    公开(公告)号：WO2008006500A1

    公开(公告)日：2008-01-17

    申请号：PCT/EP2007/005951

    申请日：2007-07-05

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  SAROFIM, Emad ,  ELSENHANS, Olivier ,  KOPP, Martin ,  WAHL, Hans-Peter ,  SAVATIC, Goran ,  HUTTER, Roland Christof

    Inventor： SAROFIM, Emad ,  ELSENHANS, Olivier ,  KOPP, Martin ,  WAHL, Hans-Peter ,  SAVATIC, Goran ,  HUTTER, Roland Christof

    IPC: B01L3/00 ,  C12Q1/68 ,  G01N35/00

    CPC classification number: B01L3/502715 ,  G01N35/0099 ,  G01N2035/00346

    Abstract: The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).

    Abstract translation: 本发明的实施例涉及一种自动装置（55），其被设计用于执行核酸分析，任选地包括样品制备，具有集成的一次性样品保持和处理装置（1），所述装置（1）包括样品 用装置（55）进行分析。 装置（55）包括用于接收，保持和处理这种集成的一次性装置（1），用于试剂（25）的试剂台（56），用于执行致动器的运动的传送装置（36） 用于处理所述一次性装置（1）中的样品（32）和试剂的流体致动装置，用于加热或冷却的温度控制装置（37），用于测量经处理样品（32）的性质的检测装置，以及用于控制 样品（32）制备，一次性装置（1）的处理和由装置（55）进行的样品分析。

    BODY FLUID SAMPLING DEVICE
    8.
    发明申请
    BODY FLUID SAMPLING DEVICE 审中-公开
    身体液体取样装置

    公开(公告)号：WO2005084530A2

    公开(公告)日：2005-09-15

    申请号：PCT/EP2005/002273

    申请日：2005-03-04

    Applicant: F. HOFFMANN-LA ROCHE AG ,  ROCHE DIAGNOSTICS GMBH ,  CALASSO, Irio ,  GRISS, Patrick ,  JÄGGI, Rainer ,  SAROFIM, Emad

    Inventor： CALASSO, Irio ,  GRISS, Patrick ,  JÄGGI, Rainer ,  SAROFIM, Emad

    IPC: A61B5/00

    CPC classification number: A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

    Abstract: Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone (45) for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.

    Abstract translation: 体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收装置（40） 从所述流体通道使得所述通路中的流体最初不会接触流体接收装置。 所述流体接收装置可以具有用于进行分析反应的测试区（45）。 来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。

    BENT MICROFLUIDIC DEVICE
    10.
    发明申请
    BENT MICROFLUIDIC DEVICE 审中-公开
    弯曲微流体装置

    公开(公告)号：WO2006053461A3

    公开(公告)日：2006-08-03

    申请号：PCT/CH2005000688

    申请日：2005-11-22

    Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH ,  EFFENHAUSER CARLO ,  SAROFIM EMAD ,  KORNER STEPHAN

    Inventor： EFFENHAUSER CARLO ,  SAROFIM EMAD ,  KORNER STEPHAN

    IPC: B01L3/00 ,  B01L3/02 ,  B41J2/16 ,  G01N35/10

    CPC classification number: G01N1/20 ,  B01L3/0244 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2400/025 ,  B01L2400/0406 ,  Y10T29/49826 ,  Y10T436/110833 ,  Y10T436/2575

    Abstract: A device for sampling, transporting and/or disposal of fluid media in the nl and µl-range comprises a substrate with an open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open or closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

    Abstract translation: 用于在nl和μl范围内采样，运输和/或处理流体介质的装置包括分别具有开放或封闭的毛细管状凹槽或通道的基底，分别具有开口或封闭的凹槽或毛细管的基底被弯曲或 至少在一个位置弧形。 衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。 针状，直线切割，尖端状，至少半圆形，圆形等。

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