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公开(公告)号：EP1315715A1
公开(公告)日：2003-06-04
申请号：EP01964612.4
申请日：2001-08-17
Applicant: Millennium Pharmaceuticals, Inc. , Kyowa Hakko Kogyo Co., Ltd , Pandey, Anjali , Scarborough, Robert M. , Matsuno, Kenji , Ichimura, Michio , Nomoto, Yugi , Ide, Shinichi , Tsukuda, Eiji , Irie, Junko , Oda, Shoji
Inventor： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC: C07D403/12 , C07D239/94 , C07D401/12
CPC classification number: C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
Abstract: The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
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公开(公告)号：EP1910624A1
公开(公告)日：2008-04-16
申请号：EP06765113.3
申请日：2006-07-26
Applicant: Scarborough, Robert James
Inventor： Scarborough, Robert James
Abstract: A portable 'surface covering' for mainly outdoor use, in a horizontal or inclined plane, subject to support from the underlying substratum. The 'surface covering' has means to maintain its position in loose, unstable, easily penetrated substratum, using tube pegs, 'envelopes', or a down-turned edge or edges/fin or fins; with versions made from a range of materials of various flexibilities/strength. The 'surface covering' in one embodiment is smooth, used as a slide, and has versions that can be multi or single lane, various lengths, one piece, or requiring assembly from a plurality of pieces or units, which may overlap other units to create various length slides, hi the inventions pathway/cycleway embodiment each individual unit may also be physically linked at the point of overlap and the surface be of a non-slip nature. Fig.12 shows how a representation of the 'surface covering' can be arranged.
Abstract translation: 一种便携式“表面覆盖物”，主要用于户外使用，在水平或倾斜平面上，受到下层底层的支持。 “表面覆盖物”具有使用管钉，“信封”或向下转弯的边缘或边缘/翅片或翅片将其位置保持在松散，不稳定，易渗透的基层中的手段; 与各种灵活性/强度的材料制成的版本。 在一个实施例中，“表面覆盖物”是光滑的，用作滑动件，并且具有可以是多个或单个通道，各种长度，单件，或需要从多个片或单元组装的版本， 创建各种长度的滑道。在本发明的路径/循环路径实施例中，每个单独的单元也可以在重叠点物理连接并且表面具有防滑性。 图12显示了如何布置“表面覆盖物”的表示。
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公开(公告)号：GB201604853D0
公开(公告)日：2016-05-04
申请号：GB201604853
申请日：2016-03-22
Applicant: SCARBOROUGH ROBERT J
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公开(公告)号：GB2461968B
公开(公告)日：2011-01-05
申请号：GB0909619
申请日：2009-06-04
Applicant: SCARBOROUGH ROBERT JAMES
Inventor： SCARBOROUGH ROBERT JAMES
Abstract: A portable Slide and/or Sledge; comprising one sheet or a plurality of overlapped sheets, which can be arranged and anchored to an underlying, supporting substrate thereby performing the role of a Slide; including anchorage means suitable for loose substrate such as sand, wherein at least one curved, cylindrical or tear drop configured portion of a sheet or plurality of sheets, is buried/filled with substrate, forming anchorage of the Slide. Said curved, cylindrical or tear drop configured portion of a sheet may also act as a cushioned area at one or both ends of a sheet performing the roll of a Sledge. The present invention is best illustrated by FIG. 21.
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公开(公告)号：GB201011699D0
公开(公告)日：2010-08-25
申请号：GB201011699
申请日：2009-06-04
Applicant: SCARBOROUGH ROBERT J
Abstract: A portable Slide and/or Sledge; comprising one sheet or a plurality of overlapped sheets, which can be arranged and anchored to an underlying, supporting substrate thereby performing the role of a Slide; including anchorage means suitable for loose substrate such as sand, wherein at least one curved, cylindrical or tear drop configured portion of a sheet or plurality of sheets, is buried/filled with substrate, forming anchorage of the Slide. Said curved, cylindrical or tear drop configured portion of a sheet may also act as a cushioned area at one or both ends of a sheet performing the roll of a Sledge. The present invention is best illustrated by FIG. 21.
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Patent Agency Ranking
公开(公告)号：GB2455357A
公开(公告)日：2009-06-10
申请号：GB0724015
申请日：2007-12-08
Applicant: SCARBOROUGH ROBERT JAMES
Inventor： SCARBOROUGH ROBERT JAMES
IPC: A63F9/30
Abstract: A portable toy or game has three sections, top 5, middle 6 and bottom or tongue 7. The top and middle section are pivotally connected together via a hinge 4. The device may be moved from a first flat position as in figure 1 to a second position as in figures 3 and 4 wherein the top and middle sections form a jaw or open mouth configuration. In figure 3 the tongue member is extended. In use the tongue is pulled back to form a prop or stay means, 8 figure 4. Said prop acts to hold the jaws apart. An object 9, which may be a ball may be propelled toward said jaws. The jaws will close if the prop is struck and dislodged. The device may be made from plastic and may having living hinges.
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公开(公告)号：GB2462133A
公开(公告)日：2010-01-27
申请号：GB0817550
申请日：2008-09-25
Applicant: SCARBOROUGH ROBERT JAMES
Inventor： SCARBOROUGH ROBERT JAMES
Abstract: A flexible sheet 1 that can be arranged into a portable slide, comprises releasable fastening means 10,11 so that one end of the sheet can be configured into a cylindrical or tear drop shape and retained in position by the fastening means 10,11. When the slide is to be positioned over a loose substrate such as sand the cylindrical or tear shaped pocket 4 formed in the sheet can be filled with sand so as to act as an anchorage system for the slide. The slide may include a plurality of sheets joined together by hinges (2, figure 4) so that the slide may follow a curved path. A sheet 1 may also be reconfigured and used as a sledge (see figures 24-26) or sandcastle mould (see figure 19).
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公开(公告)号：GB2461968A
公开(公告)日：2010-01-27
申请号：GB0909619
申请日：2009-06-04
Applicant: SCARBOROUGH ROBERT JAMES
Inventor： SCARBOROUGH ROBERT JAMES
Abstract: At least one flexible sheet 1 can be arranged such that it may be used as either a slide or a sledge. The sheet is configurable such that at least one end of the sheet is bend back on its self to form a curved, teardrop or cylindrical tubular enclosure 4. When the sheet is used as a slide the tubular enclosure is used as an anchorage means in loose substrate such as sand. The tubular enclosure is either filled with substrate or buried in a loose substrate to anchor the slide to the substrate. When the sheet is used as a sledge the tubular enclosure acts as a cushioning as the sledge travels. The tubular enclosure may be held in the tubular configuration by releasable 10 or permanent fasteners. Also disclosed are embodiments were a flexible sheet is used as a mould, tack for toys and a pillowed covering.
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公开(公告)号：GB2435223B
公开(公告)日：2008-03-05
申请号：GB0608573
申请日：2006-05-02
Applicant: SCARBOROUGH ROBERT JAMES
Inventor： SCARBOROUGH ROBERT JAMES
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