公开(公告)号：WO2008057573A3

公开(公告)日：2008-08-07

申请号：PCT/US2007023493

申请日：2007-11-08

Applicant: LIGHTLAB IMAGING INC ,  SCHMITT JOSEPH M ,  PETERSEN CHRISTOPHER ,  OHASHI TORU ,  NAKAMATSU TETSUYA

Inventor： SCHMITT JOSEPH M ,  PETERSEN CHRISTOPHER ,  OHASHI TORU ,  NAKAMATSU TETSUYA

IPC: A61B5/00 ,  A61B8/12

CPC classification number: A61B5/0066 ,  A61B5/0095 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461

Abstract: In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.

Abstract translation: 一方面，本发明涉及一种探针。 探针包括位于护套内的护套，柔性双向旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光， 预定的光束尺寸。 所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在 扫描。

公开(公告)号：WO2006086700A3

公开(公告)日：2006-12-14

申请号：PCT/US2006004863

申请日：2006-02-10

Applicant: LIGHTLAB IMAGING INC ,  SCHMITT JOSEPH M ,  KOSKI AMANDA ,  ATLAS MICHAEL ,  PETERSEN CHRISTOPHER

Inventor： SCHMITT JOSEPH M ,  KOSKI AMANDA ,  ATLAS MICHAEL ,  PETERSEN CHRISTOPHER

IPC: A61B5/00

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/0205 ,  G01B2290/65 ,  G01B2290/70 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/8507 ,  G01N2021/1787 ,  G01N2021/8514 ,  G01N2021/8528 ,  G02B6/262

Abstract: In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to affect relative linear motion between the elongate body and the optical fiber; and a second optical assembly located at the distal portion of the elongate body and attached thereto, the second optical assembly comprising a reflector in optical communication with the first optical assembly, the reflector adapted to direct the light to a position distal to the elongate body.

Abstract translation: 一方面，本发明涉及成像探针。 所述成像探针包括具有近端和远端的细长主体，所述细长主体适于封闭可滑动光纤的一部分，所述光纤具有纵向轴线; 以及附接到光纤的远端的第一光学组件。 第一光学组件包括适于将光纤发射的光以与纵向轴线成预定角度的方式引导至平面的光束定向器，设置在细长本体的近侧部分处的线性致动器，致动器适于影响光纤之间的相对线性运动 细长主体和光纤; 以及第二光学组件，其位于细长主体的远侧部分处并且附接到第二光学组件，第二光学组件包括与第一光学组件光学连通的反射器，反射器适于将光引导至细长主体的远侧位置。

公开(公告)号：WO2006086700A2

公开(公告)日：2006-08-17

申请号：PCT/US2006/004863

申请日：2006-02-10

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  KOSKI, Amanda ,  ATLAS, Michael ,  PETERSEN, Christopher

Inventor： SCHMITT, Joseph, M. ,  KOSKI, Amanda ,  ATLAS, Michael ,  PETERSEN, Christopher

IPC: A61B5/00

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/0205 ,  G01B2290/65 ,  G01B2290/70 ,  G01N21/474 ,  G01N21/4795 ,  G01N21/8507 ,  G01N2021/1787 ,  G01N2021/8514 ,  G01N2021/8528 ,  G02B6/262

Abstract: In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to affect relative linear motion between the elongate body and the optical fiber; and a second optical assembly located at the distal portion of the elongate body and attached thereto, the second optical assembly comprising a reflector in optical communication with the first optical assembly, the reflector adapted to direct the light to a position distal to the elongate body.

Abstract translation: 一方面，本发明涉及一种成像探针。 成像探头包括具有近端和远端的细长主体，细长主体适于包围可滑动光纤的一部分，光纤具有纵向轴线; 以及附接到纤维的远端的第一光学组件。 第一光学组件包括光束引导器，其适于将从光纤发射的光引导到与纵向轴线成预定角度的平面;线性致动器，设置在细长主体的近端部分处，致动器适于影响 细长体和光纤; 以及第二光学组件，其位于细长主体的远端部分并附接到其上，第二光学组件包括与第一光学组件光学连通的反射器，反射器适于将光引导到远离细长主体的位置。

公开(公告)号：WO2011090744A3

公开(公告)日：2012-01-19

申请号：PCT/US2010062330

申请日：2010-12-29

Applicant: LIGHTLAB IMAGING INC ,  SCHMITT JOSEPH M ,  PETROFF CHRISTOPHER

Inventor： SCHMITT JOSEPH M ,  PETROFF CHRISTOPHER

IPC: A61B5/00 ,  A61B5/0215

CPC classification number: A61B5/02154 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/6852 ,  A61B5/742

Abstract: An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.

Abstract translation: 光学相干断层扫描系统和集成压力测量方法。 在一个实施例中，系统包括干涉仪，包括：波长扫描激光; 与波长扫描激光器通信的源臂; 与参考反射器连通的参考臂; 具有信号输出的第一光电检测器; 与第一光电检测器连通的检测器臂，探针接口; 与所述探针接口的第一光学连接器连通的样品臂; 一种采集和显示系统，包括：具有与第一光电检测器信号输出通信的信号输入的信号输出的A / D转换器; 与A / D转换器信号输出通信的处理器系统; 以及与处理器系统通信的显示器; 以及探针，其包括压力传感器并且被配置为连接到所述探针接口的所述第一光学连接器，其中所述压力传感器包括光学压力传感器。

公开(公告)号：WO2009064410A3

公开(公告)日：2009-05-22

申请号：PCT/US2008/012701

申请日：2008-11-12

Applicant: LIGHTLAB IMAGING, INC. ,  PETERSEN, Christopher ,  MCCARTIN, Stephen, M. ,  SCHMITT, Joseph, M. ,  FRIEDMAN, Joel, M.

Inventor： PETERSEN, Christopher ,  MCCARTIN, Stephen, M. ,  SCHMITT, Joseph, M. ,  FRIEDMAN, Joel, M.

IPC: A61B5/00 ,  G02B5/00

Abstract: In part, the application relates to a lens assembly. The lens assembly includes a micro-lens (86); a beam director (90) in optical communication with the micro- lens; and a substantially transparent film (94). The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director. The lens assembly may be used in the sample arm of an OCT system. The backscatter from the film can be used to adjust the path-length of the reference arm to the path-length of the sample arm, i.e., for z-offset detection.

公开(公告)号：WO2009064410A2

公开(公告)日：2009-05-22

申请号：PCT/US2008012701

申请日：2008-11-12

Applicant: LIGHTLAB IMAGING INC ,  PETERSEN CHRISTOPHER ,  MCCARTIN STEPHEN M ,  SCHMITT JOSEPH M ,  FRIEDMAN JOEL M

Inventor： PETERSEN CHRISTOPHER ,  MCCARTIN STEPHEN M ,  SCHMITT JOSEPH M ,  FRIEDMAN JOEL M

IPC: A61B5/00 ,  G02B5/00

CPC classification number: G02B23/2423 ,  A61B5/0066 ,  A61B5/6852 ,  G02B5/08

Abstract: In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro- lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.

Abstract translation: 部分地，本发明涉及一种透镜组件。 透镜组件包括微透镜; 与微透镜光通信的光束导向器; 和基本透明的薄膜。 基本透明的薄膜能够双向透射光，并产生受控量的反向散射。 另外，胶片围绕光束导向器的一部分。

公开(公告)号：WO2005041765A1

公开(公告)日：2005-05-12

申请号：PCT/US2004/036106

申请日：2004-10-28

Applicant: NELLCOR PURITAN BENNETT INCORPORATED ,  SCHMITT, Joseph, M. ,  DEBRECZENY, Martin

Inventor： SCHMITT, Joseph, M. ,  DEBRECZENY, Martin

IPC: A61B5/00

CPC classification number: G01N21/3554 ,  A61B5/0053 ,  A61B5/0059 ,  A61B5/02438 ,  A61B5/14546 ,  G01N21/359 ,  G01N2021/3181

Abstract: Devices and methods for measuring body fluid-related metric using spectrophotometry that may be used to facilitate diagnosis and therapeutic interventions aimed at restoring body fluid balance. In one embodiment, the present invention provides a device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry. The device includes a probe housing configured to be placed near a tissue location which is being monitored; light emission optics connected to the housing and configured to direct radiation at the tissue location; light detection optics connected to the housing and configured to receive radiation from the tissue location; and a processing device configured to process radiation from the light emission optics and the light detection optics to compute the metric where the metric includes a ratio of the water content of a portion of patient's tissue in relation to the lean or fat-free content of a portion of patient's tissue.

Abstract translation: 用于使用分光光度法测量体液相关度量的装置和方法，其可用于促进用于恢复体液平衡的诊断​​和治疗干预。 在一个实施方案中，本发明提供了一种用于使用光学分光光度法测量身体组织含水量度量作为患者的无脂肪组织含量的一部分的装置。 该装置包括被配置成放置在被监视的组织位置附近的探针壳体; 光发射光学器件连接到壳体并且被配置成在组织位置处引导辐射; 光检测光学器件连接到壳体并被配置为从组织位置接收辐射; 以及处理装置，其被配置为处理来自所述发光光学器件和所述光检测光学器件的辐射，以计算所述度量，其中所述度量包括患者组织的一部分的水含量相对于所述贫血或无脂肪含量的比例 部分患者组织。

公开(公告)号：WO2011090744A2

公开(公告)日：2011-07-28

申请号：PCT/US2010/062330

申请日：2010-12-29

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  PETROFF, Christopher

Inventor： SCHMITT, Joseph, M. ,  PETROFF, Christopher

IPC: A61B5/00 ,  A61B5/0215

CPC classification number: A61B5/02154 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/02007 ,  A61B5/0215 ,  A61B5/6852 ,  A61B5/742

Abstract: An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.

Abstract translation: 光学相干断层扫描系统和集成压力测量方法。 在一个实施例中，系统包括干涉仪，包括：波长扫描激光; 与波长扫描激光器通信的源臂; 与参考反射器连通的参考臂; 具有信号输出的第一光电检测器; 与第一光电检测器连通的检测器臂，探针接口; 与所述探针接口的第一光学连接器连通的样品臂; 一种采集和显示系统，包括：具有与第一光电检测器信号输出通信的信号输入的信号输出的A / D转换器; 与A / D转换器信号输出通信的处理器系统; 以及与处理器系统通信的显示器; 以及探针，其包括压力传感器并且被配置为连接到所述探针接口的所述第一光学连接器，其中所述压力传感器包括光学压力传感器。

公开(公告)号：WO2009149131A1

公开(公告)日：2009-12-10

申请号：PCT/US2009/046035

申请日：2009-06-02

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M. ,  XU, Chenyang

Inventor： SCHMITT, Joseph, M. ,  XU, Chenyang

IPC: A61B5/00 ,  G01N21/47

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/7264

Abstract: A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.

Abstract translation: 用于确定通过光学相干断层摄影（OCT）成像的组织或组织的性质的方法和装置。 在一个实施例中，测量OCT光束的后向散射和衰减，并且基于这些测量，并且针对对应于该部分的后向散射和衰减的特定值的图像的每个部分分配诸如颜色的标记。 然后用标记显示图像，然后用户可以确定组织特征。 在替代实施例中，通过给出反向散射和衰减值的组合的程序，组织特征被自动分类。

公开(公告)号：WO2008086017A1

公开(公告)日：2008-07-17

申请号：PCT/US2008/000341

申请日：2008-01-10

Applicant: LIGHTLAB IMAGING, INC. ,  SCHMITT, Joseph, M.

Inventor： SCHMITT, Joseph, M.

IPC: A61B5/00 ,  G01B9/02

CPC classification number: G01B9/02091 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02004 ,  G01B9/02043 ,  G01B9/02069 ,  G01B2290/25 ,  G01B2290/60 ,  H01S3/1062 ,  H01S5/141 ,  H01S5/146 ,  H01S5/5036

Abstract: In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.

Abstract translation: 在本发明的一个实施例中，选择激光环中的半导体光放大器（SOA）以提供低偏振相关增益（PDG），并且选择在环外部的升压半导体光放大器以提供高偏振相关 获得。 使用具有低偏振相关增益的半导体光放大器几乎消除了在激光器的输出处的光的偏振状态的变化，但是不消除激光器的输出处的偏振状态的扫描内变化， 这可能会降低SS-OCT系统的性能。