中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

515 records (took 0.021 seconds)

    RECOMBINANT ANTIGEN CONTAINING IN ITS SEQUENCE A HETEROLOGOUS IMMUNOSTIMULATORY DOMAIN-USE AS A VACCINE
    1.
    发明申请
    RECOMBINANT ANTIGEN CONTAINING IN ITS SEQUENCE A HETEROLOGOUS IMMUNOSTIMULATORY DOMAIN-USE AS A VACCINE 审中-公开
    重组抗原在其序列中含有异源免疫球蛋白作为疫苗使用

    公开(公告)号：WO1993019185A1

    公开(公告)日：1993-09-30

    申请号：PCT/EP1993000685

    申请日：1993-03-22

    Applicant: BIOCINE SCLAVO SPA ,  VILLA, Luigi ,  GHIARA, Paolo

    Inventor： BIOCINE SCLAVO SPA

    IPC: C12N15/62

    CPC classification number: C12N15/62 ,  A61K39/00 ,  C07K14/255 ,  C07K14/47 ,  C07K14/545 ,  C07K2319/00

    Abstract: A recombinant peptide antigen within the amino acid sequence of which is contained the amino acid sequence of a heterologous immunostimulatory domain, provided that the peptide antigen is not an interleukin-1 inhibitor, is provided. The invention further provides vaccine compositions containing one or more antigens according to the invention and methods for using these vaccines and methods for producing the peptide antigens by recombinant DNA techniques.

    Abstract translation: 提供其抗原的氨基酸序列中的重组肽抗原含有异源免疫刺激结构域的氨基酸序列，条件是肽抗原不是白细胞介素-1抑制剂。 本发明还提供含有根据本发明的一种或多种抗原的疫苗组合物和使用这些疫苗的方法和通过重组DNA技术产生肽抗原的方法。

    CONJUGATES FORMED FROM HEAT SHOCK PROTEINS AND OLIGO- OR POLYSACCHARIDES
    2.
    发明申请
    CONJUGATES FORMED FROM HEAT SHOCK PROTEINS AND OLIGO- OR POLYSACCHARIDES 审中-公开
    由热休克蛋白和寡糖或多糖形成的结合物

    公开(公告)号：WO1993017712A2

    公开(公告)日：1993-09-16

    申请号：PCT/EP1993000516

    申请日：1993-03-08

    Applicant: BIOCINE SCLAVO SPA ,  RAPPUOLI, Rino ,  COSTANTINO, Paolo ,  VITI, Stefano ,  NORELLI, Francesco

    Inventor： BIOCINE SCLAVO SPA

    IPC: A61K47/48

    CPC classification number: A61K39/095 ,  A61K38/00 ,  A61K39/00 ,  A61K47/646 ,  C07K14/205 ,  C07K14/35 ,  C07K2319/35 ,  C07K2319/40 ,  Y02A50/476

    Abstract: A conjugate compound comprises at least one heat shock protein or portion thereof including at least one immunostimulatory domain and at least one capsular oligosaccharide or polysaccharide of a pathogenic bacteria. The compound comprises oligosaccharides of the Meningococci C (MenC) group and a heat shock protein selected from M. bovis BCG GroEl-type 65kDa hsp (hspR65), recombinant M. tuberculosis DnaK-type 70kDa hsp (hspR70) and a heat shock protein from H. pylori. The conjugate compounds are useful in the preparation of vaccines to prevent bacterial infection.

    Abstract translation: 缀合化合物包含至少一种热休克蛋白或其部分，其包含至少一种免疫刺激结构域和至少一种致病菌的荚膜寡糖或多糖。 该化合物包括脑膜炎球菌C（MenC）组的寡糖和选自牛分枝杆菌BCG GroE1型65kDa hsp（hspR65），重组结核分枝杆菌DnaK型70kDa hsp（hspR70）和热休克蛋白的热休克蛋白， 幽门螺杆菌 缀合物可用于制备疫苗以预防细菌感染。

    IMMUNOGENIC DETOXIFIED MUTANTS OF CHOLERA TOXIN AND OF THE TOXIN LT, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF VACCINES
    3.
    发明申请
    IMMUNOGENIC DETOXIFIED MUTANTS OF CHOLERA TOXIN AND OF THE TOXIN LT, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF VACCINES 审中-公开
    辣椒素毒素和毒素LT的免疫原性脱氧他们的制备及其用于制备疫苗的用途

    公开(公告)号：WO1993013202A1

    公开(公告)日：1993-07-08

    申请号：PCT/EP1992003016

    申请日：1992-12-30

    Applicant: BIOCINE SCLAVO SPA ,  DOMENIGHINI, Mario ,  RAPPUOLI, Rino ,  PIZZA, Mariagrazia ,  HOL, Wim

    Inventor： BIOCINE SCLAVO SPA

    IPC: C12N15/00

    CPC classification number: A61K38/164 ,  A61K39/00 ,  C07K14/245 ,  C07K14/28 ,  Y02A50/472

    Abstract: An immunogenic detoxified protein comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding to Val-53, Ser-63, Val-97, Tyr-104 or Pro-106 are replaced with another amino acid or deleted. Examples of specific replacements include Val-53-Asp, Val-53-Glu, Val-53-Tyr, Ser-63-Lys, Val-97-Lys, Val-97-Tyr, Tyr-104-Lys, Tyr-104-Asp, Tyr-104-Ser, Pro-106-Ser. The immunogenic detoxified protein is useful as vaccine for Vibrio cholerae or an enterotoxigenic strain of Escherichia coli and is produced by recombinant DNA means by site-directed mutagenesis.

    Abstract translation: 一种免疫原性解毒蛋白，其包含霍乱毒素（CT-A）亚基A或大肠杆菌热不稳定毒素（LT-A）或其片段的亚基A的氨基酸序列或其片段中的一个或多个氨基酸， 对应于Val-53，Ser-63，Val-97，Tyr-104或Pro-106被替换为另一种氨基酸或缺失。 具体替代的实例包括Val-53-Asp，Val-53-Glu，Val-53-Tyr，Ser-63-Lys，Val-97-Lys，Val-97-Tyr，Tyr-104-Lys，Tyr-104 -Asp，Tyr-104-Ser，Pro-106-Ser。 免疫原性解毒蛋白质可用作霍乱弧菌或大肠杆菌肠毒素菌株的疫苗，并通过重组DNA方法通过定点诱变产生。

Patent Agency Ranking