公开(公告)号：WO2010150257A3

公开(公告)日：2011-05-19

申请号：PCT/IL2010000501

申请日：2010-06-23

Applicant: MEDINGO LTD ,  YODFAT OFER ,  GESCHEIT IDDO M ,  SHAPIRA GALI

Inventor： YODFAT OFER ,  GESCHEIT IDDO M ,  SHAPIRA GALI

IPC: A61B5/1468

CPC classification number: A61M5/168 ,  A61B5/14532 ,  A61B5/4839 ,  A61K38/28 ,  A61M5/1723

Abstract: Disclosed are systems, devices, and methods, including a system that includes a processor-based device implementing at least a residual insulin (RI) determination unit configured to determine a residual insulin in the patient's body at a particular time instance based on bolus doses previously delivered to the body of the patient, each bolus dose being associated with at least one dose value and a time representative of the time that dose value was delivered to the patient's body, and based on dose dependent RI time records that each includes at least a dose value and an associated duration value representative of dose-dependent duration of therapeutic effectiveness of the associated at least the dose value. The system also includes a pump to controllably dispense the insulin from a reservoir to the body of the patient based on the residual insulin determined by the RI determination unit.

Abstract translation: 公开了系统，设备和方法，包括系统，其包括实施至少残留胰岛素（RI）确定单元的基于处理器的设备，其被配置为基于先前的推注剂量在特定时间段确定患者体内的残留胰岛素 递送到患者体内，每次推注剂量与至少一个剂量值和代表剂量值被递送给患者身体的时间的时间相关联，并且基于剂量依赖性RI时间记录，每个包含至少一个 剂量值和相关联的持续时间值，其代表相关联的至少剂量值的治疗有效性的剂量依赖性持续时间。 该系统还包括泵，用于基于由RI确定单元确定的残留胰岛素将胰岛素从储存器可控地分配给患者的身体。

公开(公告)号：WO2009133558A3

公开(公告)日：2010-06-10

申请号：PCT/IL2009000454

申请日：2009-04-28

Applicant: MEDINGO LTD ,  YODFAT OFER ,  GESCHEIT IDDO M ,  SHAPIRA GALI

Inventor： YODFAT OFER ,  GESCHEIT IDDO M ,  SHAPIRA GALI

IPC: A61M5/142 ,  G06F19/00

CPC classification number: A61M5/14248 ,  A61M5/1723 ,  A61M2005/14296 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3592 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/3468

Abstract: Embodiments of the present disclosure include methods, systems and devices for selecting a bolus configuration and may include one or more of providing a user interface for selection of one or more user interface elements, where each element corresponds to a bolus configuration of a drug, each element is spatially positioned within a multi-dimensional space corresponding to at least three dimensions and the element's position corresponding to each dimension.

Abstract translation: 本公开的实施例包括用于选择推注配置的方法，系统和设备，并且可以包括提供用于选择一个或多个用户界面元素的用户界面中的一个或多个，其中每个元素对应于药物的推注配置，每个 元素在空间上位于对应于至少三维的多维空间中，并且元素的位置对应于每个维度。

公开(公告)号：WO2010029551A3

公开(公告)日：2010-03-18

申请号：PCT/IL2009/000888

申请日：2009-09-10

Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  LEVY, Aharon

Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  LEVY, Aharon

IPC: G06F19/00

Abstract: Methods and devices for delivering therapeutic fluid to the body are described. The method may include determining a bolus delivery pattern based on a specific dietary intake of a patient and delivering the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern. The devices used in conjunction with the disclosed methods may include a controller to determine a bolus delivery pattern based on a specific dietary intake of the patient and an infusion pump to deliver the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern.

公开(公告)号：WO2010029551A2

公开(公告)日：2010-03-18

申请号：PCT/IL2009000888

申请日：2009-09-10

Applicant: MEDINGO LTD ,  YODFAT OFER ,  SHAPIRA GALI ,  LEVY AHARON

Inventor： YODFAT OFER ,  SHAPIRA GALI ,  LEVY AHARON

IPC: G06F19/00

CPC classification number: G06F19/3468 ,  G16H50/70

Abstract: Methods and devices for delivering therapeutic fluid to the body are described. The method may include determining a bolus delivery pattern based on a specific dietary intake of a patient and delivering the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern. The devices used in conjunction with the disclosed methods may include a controller to determine a bolus delivery pattern based on a specific dietary intake of the patient and an infusion pump to deliver the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern.

Abstract translation: 描述了用于将治疗流体输送到身体的方法和装置。 该方法可以包括基于患者的特定饮食摄入确定推注递送模式，并且至少部分地基于确定的推注递送模式将治疗流体递送到患者体内。 结合所公开的方法使用的装置可以包括控制器，用于基于患者的具体饮食摄入量和输注泵来确定推注输送模式以将治疗流体输送到患者体内，至少部分地基于 确定的推注递送模式。

公开(公告)号：WO2009095908A2

公开(公告)日：2009-08-06

申请号：PCT/IL2009000104

申请日：2009-01-28

Applicant: MEDINGO LTD ,  YODFAT OFER ,  SHAPIRA GALI

Inventor： YODFAT OFER ,  SHAPIRA GALI

IPC: G06F19/00

CPC classification number: A61M5/14248 ,  A61M5/1723 ,  A61M2005/14268 ,  A61M2005/14296 ,  A61M2205/3592 ,  A61M2230/201 ,  G06F19/3468

Abstract: Disclosed is a medical device to treat diabetes. The medical device includes a bolus calculator to determine an insulin bolus based on, at least in part, a glycemic index value associated with an intake to be consumed by a user, the bolus calculator further adapted to determine the insulin bolus using one or more inputs selected from the group consisting of carbohydrate load of the intake, current glucose level of the user, residual insulin of the user, carbohydrate to insulin ratio, insulin sensitivity of the user and target glucose level of the user. The bolus calculator is housed in one or more of, for example, an insulin dispensing pump, a handheld remote control unit for an insulin dispensing pump and/or a handheld glucose monitor.

Abstract translation: 公开了一种治疗糖尿病的医疗器械。 所述医疗装置包括推注计算器，用于至少部分地基于要由用户消耗的摄入量的血糖指数值来确定胰岛素团块，所述推注计算器还适于使用一个或多个输入来确定胰岛素推注 选自摄入量的碳水化合物，使用者的当前葡萄糖水平，使用者的剩余胰岛素，碳水化合物与胰岛素的比例，使用者的胰岛素敏感度和使用者的目标葡萄糖水平。 大剂量计算器容纳在例如胰岛素分配泵，用于胰岛素分配泵的手持式遥控单元和/或手持葡萄糖监测器中的一种或多种中。

公开(公告)号：WO2009001348A1

公开(公告)日：2008-12-31

申请号：PCT/IL2008/000862

申请日：2008-06-25

Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo, M.

Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo, M.

IPC: G06F19/00 ,  G01N33/66

CPC classification number: A61M5/1723 ,  A61M5/1413 ,  A61M5/14244 ,  A61M5/14248 ,  A61M2005/14296 ,  A61M2230/20 ,  G01N33/66 ,  G01N2800/042 ,  G06F19/00 ,  G06F19/3456 ,  G16H20/17 ,  G16H50/50

Abstract: A method and a system for determining insulin sensitivity (IS) is described. In one aspect the method and the system can be.implemented by receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue;. applying a first kinetic. model to obtain a plasma insulin concentration based on the first parameter; receiving a second parameter corresponding to a plasma glucose concentration; determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter. In the preferred methods, the level of plasma insulin in a diabetic patient is predicted by means of the Kobayashi's model on the basis of the rate of continuous s.c. insulin infusion,.and IS is calculated by means of the QUICKI or the HOMA model on the basis of this prediction and the glucose data.

Abstract translation: 描述了用于确定胰岛素敏感性（IS）的方法和系统。 在一个方面，该方法和系统可以通过接收对应于皮下组织中的胰岛素剂量的第一参数来实现。 应用第一动力学。 模型，以获得基于第一参数的血浆胰岛素浓度; 接收对应于血浆葡萄糖浓度的第二参数; 基于血浆胰岛素浓度和第二参数确定胰岛素敏感性（IS）。 在优选的方法中，糖尿病患者的血浆胰岛素水平是通过Kobayashi模型根据连续血糖的速率预测的。 基于该预测和葡萄糖数据，通过QUICKI或HOMA模型计算胰岛素输注，IS。

公开(公告)号：WO2011030343A1

公开(公告)日：2011-03-17

申请号：PCT/IL2010/000744

申请日：2010-09-07

Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo M.

Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo M.

IPC: A61K9/00

CPC classification number: A61M5/16877 ,  A61M5/14244 ,  A61M5/16804 ,  A61M5/16831 ,  A61M5/172 ,  A61M2205/3569 ,  G06F19/3468

Abstract: Devices, systems and methods for adjusting fluid delivery based on past or historical fluid delivery data and/or personal parameters of a user are disclosed. Devices, and corresponding systems and methods, may comprise a dispensing unit configured to deliver a fluid from a reservoir into the body of a user and a processor having instructions operating thereon to retrieve data relating to one or more time windows from a memory, assess a correction delivery for the one or more time windows based on the data, determine a new CIR value for the one or more time windows if the correction delivery regularly follows a meal bolus and/or determine a new basal delivery profile for the one or more time windows if the correction delivery regularly precedes a meal bolus.

Abstract translation: 公开了用于基于过去或历史的流体输送数据和/或用户的个人参数来调节流体输送的装置，系统和方法。 设备和相应的系统和方法可以包括分配单元，其被配置为将流体从储存器输送到用户的身体中;以及处理器，其具有在其上操作的指令以从存储器检索与一个或多个时间窗口相关的数据， 基于数据对一个或多个时间窗口进行校正传送，如果校正传送定期地跟随膳食推注和/或确定一个或多个时间的新的基础传送配置文件，则确定一个或多个时间窗口的新的CIR值 如果校正交付经常在餐前推注，则窗口。

公开(公告)号：WO2010023666A3

公开(公告)日：2010-03-04

申请号：PCT/IL2009/000827

申请日：2009-08-27

Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Illai

Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Illai

IPC: A61M5/142 ,  A61M37/00 ,  A61B18/04 ,  A61B18/12

Abstract: Products and methods directed to the improved infusion of fluids are disclosed. Such products and methods can be used to more efficiently and efficaciously administer therapeutic pharmaceuticals to a subject in need of treatment. In many instances, the systems comprise a therapeutic fluid delivery system and a mechanism for enhancing the absorption of the therapeutic fluid.. The enhancement of the absorption of the therapeutic fluid is generally performed locally i.e., at or near the site of administration of the therapeutic fluid. The system and methods can be used to deliver any number of therapeutic fluids including but not limited to insulin.

公开(公告)号：WO2010023666A2

公开(公告)日：2010-03-04

申请号：PCT/IL2009000827

申请日：2009-08-27

Applicant: MEDINGO LTD ,  YODFAT OFER ,  SHAPIRA GALI ,  GESCHEIT ILLAI

Inventor： YODFAT OFER ,  SHAPIRA GALI ,  GESCHEIT ILLAI

IPC: A61M5/142 ,  A61B18/04 ,  A61B18/12 ,  A61M37/00

CPC classification number: A61B18/14 ,  A61B18/20 ,  A61B2017/00765 ,  A61M5/1413 ,  A61M5/14248 ,  A61M5/1723 ,  A61M2005/14268 ,  A61M2005/1587 ,  A61M2037/0007 ,  A61M2205/36 ,  A61M2205/3653 ,  A61M2230/201

Abstract: Products and methods directed to the improved infusion of fluids are disclosed. Such products and methods can be used to more efficiently and efficaciously administer therapeutic pharmaceuticals to a subject in need of treatment. In many instances, the systems comprise a therapeutic fluid delivery system and a mechanism for enhancing the absorption of the therapeutic fluid.. The enhancement of the absorption of the therapeutic fluid is generally performed locally i.e., at or near the site of administration of the therapeutic fluid. The system and methods can be used to deliver any number of therapeutic fluids including but not limited to insulin.

Abstract translation: 公开了针对改进的流体输注的产品和方法。 这些产品和方法可以用于更有效和有效地将治疗药物施用于需要治疗的受试者。 在许多情况下，该系统包括治疗性流体输送系统和用于增强治疗性流体吸收的机制。治疗性流体的吸收的增强通常在局部施用，即在治疗剂的施用部位或附近 流体。 该系统和方法可用于递送任何数量的治疗流体，包括但不限于胰岛素。

公开(公告)号：WO2009060432A1

公开(公告)日：2009-05-14

申请号：PCT/IL2008/001443

申请日：2008-11-04

Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali

Inventor： YODFAT, Ofer ,  SHAPIRA, Gali

IPC: A61B5/00 ,  A61M5/14

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6849 ,  A61B5/6865 ,  A61M5/14248 ,  A61M5/1723 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2005/1726 ,  A61M2230/201

Abstract: Methods, systems and devices for preventing diabetic complications are provided. In some embodiments, methods, systems and devices can be implemented using at least one subcutaneously insertable element, the element having a proximal portion and a distal portion, the proximal portion coupled to the housing, the distal portion configured for subcutaneous placement within a human body; a plurality of electrodes coupled to the distal portion of the at least one subcutaneously insertable element; and, a processor adapted to correlate a signal received from the plurality of electrodes to a concentration of ketone in the human body.

Abstract translation: 提供了用于预防糖尿病并发症的方法，系统和装置。 在一些实施例中，方法，系统和装置可以使用至少一个皮下可插入元件实现，所述元件具有近端部分和远端部分，所述近端部分联接到所述外壳，所述远端部分被配置为皮下放置在人体内 ; 耦合到所述至少一个皮下可插入元件的远端部分的多个电极; 以及适于将从多个电极接收的信号与人体中的酮浓度相关联的处理器。