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公开(公告)号：WO2017150692A1
公开(公告)日：2017-09-08
申请号：PCT/JP2017/008384
申请日：2017-03-02
Applicant: RICOH COMPANY, LTD. , SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION , ONOUE, Satomi , SATO, Hideyuki , SETO, Yoshiki , MORITANI, Tatsuru , MORINAGA, Tadahiko
Inventor： ONOUE, Satomi , SATO, Hideyuki , SETO, Yoshiki , MORITANI, Tatsuru , MORINAGA, Tadahiko
Abstract: A method for producing particles, the method including: applying vibration to a liquid including a physiologically active substance and included in a liquid-column resonance liquid-chamber to form a standing wave based on liquid column resonance, to thereby discharge the liquid from at least one discharging port, which is formed in an amplitude direction of the standing wave, to at least one region corresponding to at least one anti-node of the standing wave; and drying the liquid discharged, to thereby form particles.
Abstract translation: 一种制造颗粒的方法，所述方法包括：向包含生理活性物质的液体施加振动并将其包括在液柱共振液体室中以基于液柱共振形成驻波， 由此将液体从在驻波的振幅方向上形成的至少一个排出口排出到与驻波的至少一个波腹对应的至少一个区域; 干燥排出的液体，从而形成颗粒。
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公开(公告)号：WO2020027030A1
公开(公告)日：2020-02-06
申请号：PCT/JP2019/029606
申请日：2019-07-29
Applicant: RICOH COMPANY, LTD. , SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION , ONOUE, Satomi , SATO, Hideyuki , MORINAGA, Tadahiko , MORITANI, Tatsuru
Inventor： ONOUE, Satomi , SATO, Hideyuki , MORINAGA, Tadahiko , MORITANI, Tatsuru
Abstract: Provided is a method for producing a particle including forming a particle composition liquid into droplets where the particle composition liquid includes a physiologically active substance and at least two dispersants, and solidifying the droplets of the particle composition liquid in a manner that at least one of the at least two dispersants is locally present at the surface side of the particle.
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公开(公告)号：US20230383320A1
公开(公告)日：2023-11-30
申请号：US17979878
申请日：2022-11-03
Applicant: SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION , NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
Inventor： Hiroshi Kikukawa , Toru Suzuki
IPC: C12P7/6409 , A61K8/36 , A61Q19/00 , C12N1/20 , A23L33/12
CPC classification number: C12P7/6409 , A61K8/361 , A61Q19/00 , C12N1/205 , A23L33/12 , A61K2800/10 , A61K2800/85 , C12R2001/01
Abstract: Provided is a method for producing a monounsaturated fatty acid having 16 carbon atoms by a method other than chemical synthesis. The method for producing a monounsaturated fatty acid having 16 carbon atoms comprises a step of culturing bacteria of the genus Bifidobacterium capable of producing a monounsaturated fatty acid having 16 carbon atoms in a liquid medium.
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公开(公告)号：US20220401590A1
公开(公告)日：2022-12-22
申请号：US17772259
申请日：2020-11-04
Applicant: SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION , MEDICAL CORPORATION KINSHUKAI , HAMAMATSU PHOTONICS K.K.
Inventor： Kenichiro TODOROKI , Yoshitaka HAMASHIMA , Hiromichi EGAMI , Satoshi NAKAGAWA , Toshihiro SAKAI , Osamu INOUE , Shingo NISHIYAMA , Masakatsu KANAZAWA , Hideo TSUKADA
Abstract: The present invention relates to a compound represented by the following General Formula (1) or a salt thereof. In General Formula (1), R1, R2, R3 and R4 each independently represent a hydrogen atom, a linear or branched alkyl group which may have a substituent or the like. R1 and R2 may be bonded to each other to form a ring. R3 and R4 may be bonded to each other to form a ring. R1 and/or R2 may be bonded to a 6-membered ring to which —NR1R2 is bonded to form a ring. R3 and/or R4 may be bonded to a 6-membered ring to which —NR3R4 is bonded to form a ring. R5 represents —11CH3, a linear or branched alkyl group which may have a substituent or the like. R6 represents —F, —18F or the like. X, Y and Z each independently represent a carbon atom, an oxygen atom or the like. n is 0 or 1.
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公开(公告)号：US20220241422A1
公开(公告)日：2022-08-04
申请号：US17620192
申请日：2020-05-07
Inventor： Takanori KANAZAWA , Yasuhiro KOSUGE , Hiroko MIYAGISHI , Naoto SUZUKI
Abstract: A drug delivery composition for delivering a drug to the spinal cord, the drug delivery composition containing a block copolymer having a polyethylene glycol segment and a hydrophobic polyester segment linked together, and a membrane-permeable peptide, in which the drug delivery composition is administered nasally. A pharmaceutical composition for treating a spinal cord disease, the pharmaceutical composition containing the above-mentioned drug delivery composition and a drug for treatment of a spinal cord disease, in which the pharmaceutical composition is administered nasally.
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Patent Agency Ranking
公开(公告)号：US20210308068A1
公开(公告)日：2021-10-07
申请号：US17264090
申请日：2019-07-29
Inventor： Satomi ONOUE , Hideyuki SATO , Tadahiko MORINAGA , Tatsuru MORITANI
Abstract: Provided is a method for producing a particle including forming a particle composition liquid into droplets where the particle composition liquid includes a physiologically active substance and at least two dispersants, and solidifying the droplets of the particle composition liquid in a manner that at least one of the at least two dispersants is locally present at the surface side of the particle.
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公开(公告)号：US20230210767A1
公开(公告)日：2023-07-06
申请号：US17998895
申请日：2021-05-18
Inventor： Tatsuru MORITANI , Satomi ONOUE , Hideyuki SATO
CPC classification number: A61K9/0075 , A61K9/1617 , A61K9/5123 , A61K9/5089 , A61K38/13
Abstract: A particle includes at least one or more kinds of substrate and lipid nanoparticles. The lipid nanoparticles are dispersed in the substrate and contain a physiologically active substance. The lipid nanoparticles are one or more kinds selected from liposomes, lipid emulsions, and solid lipid nanoparticles. A corresponding powder inhalant contains the particle. A production method for the particle includes granulating and drying, in which a suspension containing the substrate and the lipid nanoparticles are granulated and dried in a gas medium.
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公开(公告)号：US11234984B2
公开(公告)日：2022-02-01
申请号：US16765575
申请日：2018-11-28
Inventor： Shigeru Itai , Shuji Noguchi , Yasunori Iwao , Masuharu Hirano , Takashi Ohta , Tomio Yamakawa
IPC: A61K31/519 , A61K9/19 , A61K47/38
Abstract: The present invention relates to a solid dispersion containing a compound represented by General Formula (I): wherein R1 is an unsubstituted phenyl group or a phenyl group substituted with a substituent; the substituent is an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with a halogen atom, an alkoxy group having 1 to 8 carbon atoms, an alkoxycarbonyl group having 2 to 8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a phenyl group or a phenoxy group; R2 is a cyano group or a nitro group; R3 is a hydroxyl group; X is an oxygen atom or —S(O)n—; n is an integer of 0 to 2; Y is an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof and a hypromellose derivative.
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公开(公告)号：US20200306251A1
公开(公告)日：2020-10-01
申请号：US16765575
申请日：2018-11-28
Inventor： Shigeru Itai , Shuji Noguchi , Yasunori Iwao , Masuharu Hirano , Takashi Ohta , Tomio Yamakawa
IPC: A61K31/519 , A61K47/38 , A61K9/19
Abstract: The present invention relates to a solid dispersion containing a compound represented by General Formula (1): wherein R1 is an unsubstituted phenyl group or a phenyl group substituted with a substituent; the substituent is an alkyl group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms substituted with a halogen atom, an alkoxy group having 1 to 8 carbon atoms, an alkoxycarbonyl group having 2 to 8 carbon atoms, a formyl group, a carboxyl group, a halogen atom, a phenyl group or a phenoxy group; R2 is a cyano group or a nitro group; R3 is a hydroxyl group; X is an oxygen atom or —S(O)n—; n is an integer of 0 to 2; Y is an oxygen atom or a sulfur atom, or a pharmaceutically acceptable salt thereof and a hypromellose derivative.
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公开(公告)号：US20200255901A1
公开(公告)日：2020-08-13
申请号：US16322895
申请日：2017-08-03
Inventor： Ken YAMAGUCHI , Masatoshi KUSUHARA , Masakuni SERIZAWA , Tohru MOCHIZUKI , Keiichi OHSHIMA , Keiichi HATAKEYAMA , Kenichi URAKAMI , Shumpei OHNAMI , Yasuto AKIYAMA , Kouji MARUYAMA , Kengo INOUE , Yuji SHIMODA , Takeshi NAGASHIMA , Yoshinobu ISHIKAWA
IPC: C12Q1/6886 , G01N33/574
Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.
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