公开(公告)号：WO2009022222A2

公开(公告)日：2009-02-19

申请号：PCT/IB2008/002130

申请日：2008-08-13

Applicant: SILICON BIOSYSTEMS S.P.A. ,  SIMONE, Giuseppina ,  PEROZZIELLO, Gerardo ,  MEDORO, Gianni

Inventor： SIMONE, Giuseppina ,  PEROZZIELLO, Gerardo ,  MEDORO, Gianni

IPC: C09J5/02

CPC classification number: C09J5/02 ,  C09J2400/228 ,  C09J2433/008 ,  C09J2483/00

Abstract: Method of bonding a layer (S) of silicone to a substrate (4') of methacrylic polymer; the method involves positioning between the methacrylate polymer and the silicone a layer (9) of an organosilane having the formula R 1 Si (R 2 ) 3 , in which R 2 is OH and R 1 is a methacrylic residue.

Abstract translation: 将硅树脂层（S）与甲基丙烯酸系聚合物的基材（4'）接合的方法; 该方法包括在甲基丙烯酸酯聚合物和硅氧烷之间定位具有式R 1 Si（R 2）3的有机硅烷的层（9），其中R 2是OH，R 1是甲基丙烯酸残基。

公开(公告)号：WO2010106434A1

公开(公告)日：2010-09-23

申请号：PCT/IB2010/000615

申请日：2010-03-17

Applicant: SILICON BIOSYSTEMS S.P.A. ,  MEDORO, Gianni ,  PEROZZIELLO, Gerardo ,  CALANCA, Alex ,  SIMONE, Giuseppina ,  MANARESI, Nicolò

Inventor： MEDORO, Gianni ,  PEROZZIELLO, Gerardo ,  CALANCA, Alex ,  SIMONE, Giuseppina ,  MANARESI, Nicolò

IPC: B01L3/00 ,  G01N35/00 ,  F16K99/00 ,  B03C5/00 ,  B03C5/02

CPC classification number: B03C5/026 ,  B01L3/502738 ,  B01L3/567 ,  B01L2200/0652 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2400/0424 ,  B01L2400/0622 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/26 ,  C12M47/04 ,  F16K99/0001 ,  F16K99/0015 ,  G01N2015/1081

Abstract: A microfluidic system (1) for the isolation of cells (Cl) of at least one given type from a sample; the system (1) comprises a separation unit (3), for transferring at least part of the cells (Cl) of the given type from a main chamber (4) to a recovery chamber (5) in a substantially selective way with respect to further cells (C2) of the sample; two valves (9, 10) are set upstream and downstream of the main chamber (4); two valves (11, 12) are set upstream and downstream of the recovery chamber (5); a control assembly (23) is designed to govern the aforementioned valves (9, 10, 11, 12); the system (1) proposed enables isolation of the cells with a high degree of reproducibility and precision.

Abstract translation: 一种用于从样品中分离至少一种给定类型的细胞（Cl）的微流体系统（1） 所述系统（1）包括分离单元（3），用于将所述给定类型的单元（C1）的至少一部分从主室（4）传送到回收室（5），以相对于 样品的另外的细胞（C2）; 两个阀（9,10）设置在主室（4）的上游和下游。 两个阀（11,12）设置在回收室（5）的上游和下游; 控制组件（23）被设计成控制上述阀（9,10,11,12）; 提出的系统（1）能够以高度的再现性和精度隔离电池。

公开(公告)号：WO2010106426A1

公开(公告)日：2010-09-23

申请号：PCT/IB2010/000580

申请日：2010-03-17

Applicant: SILICON BIOSYSTEMS S.P.A. ,  MEDORO, Gianni ,  PEROZZIELLO, Gerardo ,  CALANCA, Alex ,  SIMONE, Giuseppina ,  MANARESI, Nicolò

Inventor： MEDORO, Gianni ,  PEROZZIELLO, Gerardo ,  CALANCA, Alex ,  SIMONE, Giuseppina ,  MANARESI, Nicolò

IPC: B01L3/00 ,  F16K99/00 ,  G01N35/00

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0621 ,  B01L2200/0652 ,  B01L2200/0684 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/1894 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/06 ,  F16K99/0015 ,  F16K2099/008

Abstract: A microfluidic system (1) for the isolation of cells (C1) of at least one given type from a sample; the system (1) comprises a separation unit (3), for transferring at least part of the cells (C1) of the given type from a main chamber (4) to a recovery chamber (5) in a substantially selective way with respect to further cells (C2) of the sample; two valves (9, 10) are set upstream and downstream of the main chamber (4); two valves (11, 12) are set upstream and downstream of the recovery chamber (5); a control assembly (23) is designed to govern the aforementioned valves (9, 10, 11, 12); the system (1) proposed enables isolation of the cells with a high degree of reproducibility and precision.

Abstract translation: 一种用于从样品中分离至少一种给定类型的细胞（C1）的微流体系统（1） 系统（1）包括分离单元（3），用于将给定类型的单元（C1）的至少一部分从主室（4）传送到回收室（5），以相对于 样品的另外的细胞（C2）; 两个阀（9,10）设置在主室（4）的上游和下游。 两个阀（11,12）设置在回收室（5）的上游和下游; 控制组件（23）被设计成控制上述阀（9,10,11,12）; 提出的系统（1）能够以高度的再现性和精度隔离电池。

公开(公告)号：WO2010106428A3

公开(公告)日：2010-12-23

申请号：PCT/IB2010000585

申请日：2010-03-17

Applicant: SILICON BIOSYSTEMS SPA ,  MEDORO GIANNI ,  PEROZZIELLO GERARDO ,  CALANCA ALEX ,  SIMONE GIUSEPPINA ,  MANARESI NICOLO

Inventor： MEDORO GIANNI ,  PEROZZIELLO GERARDO ,  CALANCA ALEX ,  SIMONE GIUSEPPINA ,  MANARESI NICOLO

IPC: B01L3/00 ,  B03C5/02

CPC classification number: B03C5/026 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2400/0433 ,  B01L2400/0487 ,  B01L2400/0655 ,  B03C2201/02 ,  B03C2201/26

Abstract: A microfluidic system (1) for the isolation of cells (C1) of at least one given type from a sample; the system (1) comprises a separation unit (3), - for transferring at least part of the cells (Cl) of the given type from a main chamber (4) to a recovery chamber (5) in a substantially selective way with respect to further cells (C2) of the sample; two valves (9, 10) are set upstream and downstream of the main chamber (4); two valves (11, 12) are set upstream and downstream of the recovery chamber (5); a control assembly (23) is designed to govern the aforementioned valves (9, 10, 11, 12); the system (1) proposed enables isolation of the cells with a high degree of reproducibility and precision.

Abstract translation: 一种用于从样品中分离至少一种给定类型的细胞（C1）的微流体系统（1） 所述系统（1）包括分离单元（3），用于将所述给定类型的至少一部分单元（C1）从主室（4）以基本上选择性的方式传送到回收室（5），相对于 到另外的样品的细胞（C2）; 两个阀（9,10）设置在主室（4）的上游和下游。 两个阀（11,12）设置在回收室（5）的上游和下游; 控制组件（23）被设计成控制上述阀（9,10,11,12）; 提出的系统（1）能够以高度的再现性和精度隔离电池。

公开(公告)号：WO2010106428A2

公开(公告)日：2010-09-23

申请号：PCT/IB2010/000585

申请日：2010-03-17

Applicant: SILICON BIOSYSTEMS S.P.A. ,  MEDORO, Gianni ,  PEROZZIELLO, Gerardo ,  CALANCA, Alex ,  SIMONE, Giuseppina ,  MANARESI, Nicolò

Inventor： MEDORO, Gianni ,  PEROZZIELLO, Gerardo ,  CALANCA, Alex ,  SIMONE, Giuseppina ,  MANARESI, Nicolò

IPC: B01L3/00 ,  B03C5/02

CPC classification number: B03C5/026 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/0652 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2400/0433 ,  B01L2400/0487 ,  B01L2400/0655 ,  B03C2201/02 ,  B03C2201/26

Abstract: A microfluidic system (1) for the isolation of cells (C1) of at least one given type from a sample; the system (1) comprises a separation unit (3), - for transferring at least part of the cells (Cl) of the given type from a main chamber (4) to a recovery chamber (5) in a substantially selective way with respect to further cells (C2) of the sample; two valves (9, 10) are set upstream and downstream of the main chamber (4); two valves (11, 12) are set upstream and downstream of the recovery chamber (5); a control assembly (23) is designed to govern the aforementioned valves (9, 10, 11, 12); the system (1) proposed enables isolation of the cells with a high degree of reproducibility and precision.

Abstract translation: 用于从样品中分离至少一种给定类型的细胞（C1）的微流体系统（1） 系统（1）包括分离单元（3），用于以基本上选择性的方式将至少一部分给定类型的单元（C1）从主室（4）转移到回收室（5） 以进一步使样品的细胞（C2） 两个阀（9,10）设置在主室（4）的上游和下游; 两个阀（11,12）设置在回收室（5）的上游和下游; 控制组件（23）被设计成管理上述阀（9,10,11,12）; 所提出的系统（1）能够以高度的重现性和精确度分离细胞。

公开(公告)号：WO2009022222A3

公开(公告)日：2010-06-10

申请号：PCT/IB2008002130

申请日：2008-08-13

Applicant: SILICON BIOSYSTEMS SPA ,  SIMONE GIUSEPPINA ,  PEROZZIELLO GERARDO ,  MEDORO GIANNI

Inventor： SIMONE GIUSEPPINA ,  PEROZZIELLO GERARDO ,  MEDORO GIANNI

IPC: C09J5/02

CPC classification number: C09J5/02 ,  C09J2400/228 ,  C09J2433/008 ,  C09J2483/00

Abstract: Method of bonding a layer (S) of silicone to a substrate (4') of methacrylic polymer; the method involves positioning between the methacrylate polymer and the silicone a layer (9) of an organosilane having the formula R1Si (R2) 3, in which R2 is OH and R1 is a methacrylic residue.

Abstract translation: 将硅树脂层（S）与甲基丙烯酸系聚合物的基材（4'）接合的方法; 该方法包括在甲基丙烯酸酯聚合物和硅氧烷之间定位具有式R 1 Si（R 2）3的有机硅烷的层（9），其中R 2是OH，R 1是甲基丙烯酸残基。