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1.发明申请
公开(公告)号：WO2003102133A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/015192
申请日：2003-05-13
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALLBRITTON, Nancy , SIMS, Christopher, E. , HU, Shuwen , REN, Xuegin , LI, Guann-Pyng , BACHMAN, Mark
Inventor： ALLBRITTON, Nancy , SIMS, Christopher, E. , HU, Shuwen , REN, Xuegin , LI, Guann-Pyng , BACHMAN, Mark
IPC: C08J7/04
Abstract: Polymer-based biomaterials are popular due to ease of fabrication and low costs. However, many polymer substrates have undesirable surface properties. The invention provides a procedure to covalently apply a graft polymer to the surface of a polymer substrate by ultraviolet graft polymerization. The graft polymer is formed from monomers such as PEG, AA, monomethoxy acrylate PEG, HEMA, or DMA. Also, mixed monomers may be used to create the graft and the surface properties of the graft may be tailored for different properties, including hydrophobicity, friction coefficient, electroosmotic mobilities and electrophoretic separations. The invention has particular utility in tailoring surface chemistries in ocular lenses and polymer microdevices.
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2.发明申请METHOD OF MANUFACTURE OF A PLATE OF RELEASABLE ELEMENTS AND ITS ASSEMBLY INTO A CASSETTE 审中-公开可释放元素板的制造方法及其组装于CASSETTE
公开(公告)号：WO2007127990A3
公开(公告)日：2009-04-23
申请号：PCT/US2007067822
申请日：2007-04-30
Applicant: UNIV CALIFORNIA , BACHMAN MARC , WANG YULI , SIMS CHRISTOPHER E , ALLBRITTON NANCY , LI GUANN-PYNG
Inventor： BACHMAN MARC , WANG YULI , SIMS CHRISTOPHER E , ALLBRITTON NANCY , LI GUANN-PYNG
IPC: B05D3/04
CPC classification number: B01L3/502707 , B01L3/5085 , B01L3/5088 , B01L2200/0647 , B01L2300/0636 , B01L2300/0822 , B01L2300/0829 , B01L2300/089 , B01L2400/0454 , G01N2035/00158
Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.
Abstract translation: 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。
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3.发明申请USE OF PHOTOSENSITIZED EPON EPOXY RESIN 1002F FOR MEMS AND BIOMEMS APPLICATIONS 审中-公开光敏环氧树脂1002F用于MEMS和生物物质的应用
公开(公告)号：WO2009015361A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/071242
申请日：2008-07-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PAI, Jeng-Hao , WANG, Yuli , SIMS, Christopher E. , BACHMAN, Mark , ALLBRITTON, Nancy , LI, Guann-Pyng
Inventor： PAI, Jeng-Hao , WANG, Yuli , SIMS, Christopher E. , BACHMAN, Mark , ALLBRITTON, Nancy , LI, Guann-Pyng
CPC classification number: G03F7/40 , B01L3/502707 , G03F1/50 , G03F7/0037 , G03F7/038 , G03F7/095
Abstract: Systems and methods directed to the use 1002F to build microdevices and biomedical devices. Through the addition of a photosensitizing agent, Epon epoxy resin 1002F can be linked in the presence of UV light, making it useful as a photoresist or as a micropatternable structural material. One embodiment comprises combining 1002F monomer resin with a solvent and a photoinitiator, placing the monomer solution on a surface, exposing the monomer solution to UV light through a mask to initiate linking, and stripping the unlinked polymer away. In another embodiment, 3-D structures are built using two or more layers of sensitized monomer films, each having different sensitivity to light, and the use of a mask containing opaque and semi-opaque regions.
Abstract translation: 针对使用1002F构建微型设备和生物医学设备的系统和方法。 通过添加光敏剂，Epon环氧树脂1002F可以在UV光的存在下连接，使其可用作光致抗蚀剂或作为微图案化的结构材料。 一个实施方案包括将1002F单体树脂与溶剂和光引发剂组合，将单体溶液置于表面上，通过掩模将单体溶液暴露于UV光以引发连接，并将未连接的聚合物剥离。 在另一个实施方案中，使用两层或更多层敏化单体膜来构建3-D结构，每层具有不同的光敏感性，以及使用含有不透明区域和半不透明区域的掩模。
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4.发明申请SYSTEMS AND METHODS FOR EFFICIENT COLLECTION OF SINGLE CELLS AND COLONIES OF CELLS AND FAST GENERATION OF STABLE TRANSFECTANTS 审中-公开有效收集单细胞和细胞群的系统和方法以及快速生成稳定转录因子
公开(公告)号：WO2007118208A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/066171
申请日：2007-04-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALLBRITTON, Nancy , SIMS, Christopher E. , WANG, Yuli , BACHMAN, Mark , LI, Guann-Pyng , STANBRIDGE, Eric
Inventor： ALLBRITTON, Nancy , SIMS, Christopher E. , WANG, Yuli , BACHMAN, Mark , LI, Guann-Pyng , STANBRIDGE, Eric
CPC classification number: G01N1/286 , B01L3/5085 , B01L2200/0668 , B01L2300/0829 , C12M23/12 , C12M47/04 , G01N2001/2886
Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses. Use of the plate advantageously enables the selection and sorting of cells based on dynamic phenomena and the rapid establishment of stable tranfectants.
Abstract translation: 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。 板的使用有利于基于动态现象和快速建立稳定的转染剂来选择和分选细胞。
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Patent Agency Ranking5.发明申请CHEMICAL MODIFICATIONS TO POLYMER SURFACES AND THE APPLICATION OF POLYMER GRAFTING TO BIOMATERIALS 审中-公开聚合物表面的化学改性和聚合物在生物材料上的应用
公开(公告)号：WO2003102133A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/015192
申请日：2003-05-13
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALLBRITTON, Nancy , SIMS, Christopher, E. , HU, Shuwen , REN, Xuegin , LI, Guann-Pyng , BACHMAN, Mark
Inventor： ALLBRITTON, Nancy , SIMS, Christopher, E. , HU, Shuwen , REN, Xuegin , LI, Guann-Pyng , BACHMAN, Mark
IPC: C12N
CPC classification number: C08J7/18 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , G01N27/44704 , G01N27/44752 , G02B1/043
Abstract: Polymer-based biomaterials are popular due to ease of fabrication and low costs. However, many polymer substrates have undesirable surface properties. The invention provides a procedure to covalently apply a graft polymer to the surface of a polymer substrate by ultraviolet graft polymerization. The graft polymer is formed from monomers such as PEG, AA, monomethoxy acrylate PEG, HEMA, or DMA. Also, mixed monomers may be used to create the graft and the surface properties of the graft may be tailored for different properties, including hydrophobicity, friction coefficient, electroosmotic mobilities and electrophoretic separations. The invention has particular utility in tailoring surface chemistries in ocular lenses and polymer microdevices.
Abstract translation: 基于聚合物的生物材料由于易于制造和低成本而受欢迎。 然而，许多聚合物基材具有不期望的表面性质。 本发明提供了通过紫外接枝聚合将接枝聚合物共价施用到聚合物基材表面的方法。 接枝聚合物由诸如PEG，AA，单甲氧基丙烯酸酯PEG，HEMA或DMA的单体形成。 此外，可以使用混合单体来产生移植物，并且可以针对不同的性质（包括疏水性，摩擦系数，电渗迁移率和电泳分离）来调整移植物的表面性质。 本发明在定制眼镜和聚合物微型装置中的表面化学物质方面具有特别的用途。
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6.发明申请METHOD OF MANUFACTURE OF A PLATE OF RELEASABLE ELEMENTS AND ITS ASSEMBLY INTO A CASSETTE 审中-公开可释放元素板的制造方法及其组装成CASSETTE
公开(公告)号：WO2007127990A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/067822
申请日：2007-04-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BACHMAN, Marc , WANG, Yuli , SIMS, Christopher E. , ALLBRITTON, Nancy , LI, Guann-Pyng
Inventor： BACHMAN, Marc , WANG, Yuli , SIMS, Christopher E. , ALLBRITTON, Nancy , LI, Guann-Pyng
CPC classification number: B01L3/502707 , B01L3/5085 , B01L3/5088 , B01L2200/0647 , B01L2300/0636 , B01L2300/0822 , B01L2300/0829 , B01L2300/089 , B01L2400/0454 , G01N2035/00158
Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.
Abstract translation: 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。
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7.发明申请IMPROVEMENT OF CATALYTIC EFFICIENCY AND/OR SPECIFICITY OF NON-NATIVE SUBSTRATES OF ENZYMES 审中-公开提高非天然碱基的催化效率和/或特异性
公开(公告)号：WO2004068139A3
公开(公告)日：2004-11-11
申请号：PCT/US2004000529
申请日：2004-01-09
Applicant: UNIV CALIFORNIA , ALLBRITTON NANCY L , BARDWELL LEE , SIMS CHRISTOPHER E
Inventor： ALLBRITTON NANCY L , BARDWELL LEE , SIMS CHRISTOPHER E
CPC classification number: C07K1/13 , C07K2319/10 , C07K2319/23 , C07K2319/60 , C12Q1/42 , C12Q1/485 , G01N33/5005 , G01N2800/52
Abstract: A method of introducing a fluorescent label into a cell, comprising: exposing a reporter to the cell, wherein the reporter comprises: a peptide substrate for an enzyme, a docking domain for the enzyme, attached to the peptide substrate, a membrane traversing moiety, and the label.
Abstract translation: 一种将荧光标记引入细胞的方法，包括：将报道分子暴露于细胞，其中所述报道分子包含：酶的肽底物，酶的对接结构域，连接于肽底物，膜横穿部分， 和标签。
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8.发明申请IMPROVEMENT OF CATALYTIC EFFICIENCY AND/OR SPECIFICITY OF NON-NATIVE SUBSTRATES OF ENZYMES 审中-公开催化效率的提高和/或非酶底物的特异性
公开(公告)号：WO2004068139A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/000529
申请日：2004-01-09
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ALLBRITTON, Nancy, L. , BARDWELL, Lee , SIMS, Christopher, E.
Inventor： ALLBRITTON, Nancy, L. , BARDWELL, Lee , SIMS, Christopher, E.
IPC: G01N33/50
CPC classification number: C07K1/13 , C07K2319/10 , C07K2319/23 , C07K2319/60 , C12Q1/42 , C12Q1/485 , G01N33/5005 , G01N2800/52
Abstract: A method of introducing a fluorescent label into a cell, comprising: exposing a reporter to the cell, wherein the reporter comprises: a peptide substrate for an enzyme, a docking domain for the enzyme, attached to the peptide substrate, a membrane traversing moiety, and the label.
Abstract translation: 一种将荧光标记引入细胞的方法，包括：将报告物暴露于细胞，其中所述报告基团包括：用于酶的肽底物，连接到肽底物的酶的对接结构域，穿膜部分的膜， 和标签。
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公开(公告)号：WO2007118208A3
公开(公告)日：2008-11-06
申请号：PCT/US2007066171
申请日：2007-04-06
Applicant: UNIV CALIFORNIA , ALLBRITTON NANCY , SIMS CHRISTOPHER E , WANG YULI , BACHMAN MARK , LI GUANN-PYNG , STANBRIDGE ERIC
Inventor： ALLBRITTON NANCY , SIMS CHRISTOPHER E , WANG YULI , BACHMAN MARK , LI GUANN-PYNG , STANBRIDGE ERIC
IPC: C12Q1/24
CPC classification number: G01N1/286 , B01L3/5085 , B01L2200/0668 , B01L2300/0829 , C12M23/12 , C12M47/04 , G01N2001/2886
Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses. Use of the plate advantageously enables the selection and sorting of cells based on dynamic phenomena and the rapid establishment of stable tranfectants.
Abstract translation: 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构成，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。 板的使用有利于基于动态现象和快速建立稳定的转染剂来选择和分选细胞。
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