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    METHOD AND KIT FOR DETERMINING THE TIME OF SEROCONVERSION OF A PATIENT INFECTED WITH A VIRUS
    2.
    发明申请
    METHOD AND KIT FOR DETERMINING THE TIME OF SEROCONVERSION OF A PATIENT INFECTED WITH A VIRUS 审中-公开
    用于确定感染病毒的患者服用时间的方法和工具包

    公开(公告)号：WO2012127474A1

    公开(公告)日：2012-09-27

    申请号：PCT/IL2012/050103

    申请日：2012-03-22

    Applicant: SMART Biotech Ltd. ,  JEHUDA-COHEN, Tamar

    Inventor： JEHUDA-COHEN, Tamar

    IPC: C12Q1/70

    CPC classification number: G01N33/569 ,  G01N33/56983 ,  G01N33/56988 ,  G01N2469/20 ,  G01N2800/56

    Abstract: The present invention provides a method for determining the time of infection, and a method for determining if a microbial infection is in the early stages comprising the step of determining the ratio of in vitro stimulated anti-microbial immunoreactivity and un-stimulated anti-microbial immunoreactivity in blood samples from said subject and related kits.

    Abstract translation: 本发明提供了一种确定感染时间的方法，以及用于确定微生物感染是否处于早期阶段的方法，包括确定体外刺激的抗微生物免疫反应性和未刺激的抗微生物免疫反应性的比例的步骤 在来自所述受试者和相关试剂盒的血液样品中。

    METHOD AND KIT FOR ESTIMATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) INCIDENCE
    3.
    发明申请
    METHOD AND KIT FOR ESTIMATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) INCIDENCE 审中-公开
    评估人体免疫缺陷病毒（HIV）感染的方法和工具

    公开(公告)号：WO2012127473A1

    公开(公告)日：2012-09-27

    申请号：PCT/IL2012/050101

    申请日：2012-03-22

    Applicant: SMART BIOTECH LTD. ,  JEHUDA-COHEN, Tamar

    Inventor： JEHUDA-COHEN, Tamar

    IPC: G01N33/569

    CPC classification number: G01N33/56983 ,  G01N33/56988 ,  G01N2469/20 ,  G01N2800/56

    Abstract: The present invention provides a method for determining the incidence of human immunodeficiency virus (HIV) infections in a population comprising comparing the anti-HIV antibody levels of in vitro stimulated tissue samples to those of un-stimulated tissue samples from individual members of said population and related kits. The present invention also provides a method of determining the distribution of recent, non-recent, and late stage human immunodeficiency virus (HIV) infections in a population comprising comparing the in vitro stimulated anti-HIV immunoreactivity and un-stimulated anti-HIV immunoreactivity in tissue samples from individual members of said population and related kits.

    Abstract translation: 本发明提供了确定人群中人类免疫缺陷病毒（HIV）感染的发生率的方法，其包括将体外刺激的组织样品的抗HIV抗体水平与来自所述群体的个体成员的未刺激的组织样品的抗HIV抗体水平进行比较，以及 相关工具包 本发明还提供了确定人群中近期，非近期和晚期人类免疫缺陷病毒（HIV）感染的分布的方法，其包括将体外刺激的抗HIV免疫反应性和未刺激的抗HIV免疫反应性 所述种群的个体成员和相关试剂盒的组织样品。

    METHODS AND KITS FOR THE DETECTION OF AN INFECTION IN SUBJECTS WITH LOW SPECIFIC ANTIBODY LEVELS
    4.
    发明申请
    METHODS AND KITS FOR THE DETECTION OF AN INFECTION IN SUBJECTS WITH LOW SPECIFIC ANTIBODY LEVELS 审中-公开
    用于检测具有低特异性抗体水平的对象的感染的方法和试剂盒

    公开(公告)号：WO2012032512A3

    公开(公告)日：2012-07-19

    申请号：PCT/IL2011000712

    申请日：2011-09-07

    Applicant: SMART BIOTECH LTD ,  JEHUDA-COHEN TAMAR

    Inventor： JEHUDA-COHEN TAMAR

    IPC: G01N33/567 ,  C12N5/071

    CPC classification number: G01N33/56983 ,  G01N33/576 ,  G01N2333/15 ,  G01N2469/20

    Abstract: This invention relates to methods that enable the detection of antibodies against a latent infection, a chronic infection, a re-infection, and/or a breakthrough infection; enable the diagnosis of a latent infection, a chronic infection, a re-infection, and/or a breakthrough infection; and increase low anti-viral antibody levels, and a kit for the detection of virus-specific antibodies expressed at low levels.

    Abstract translation: 本发明涉及能够检测抗潜伏感染，慢性感染，再感染和/或突破性感染的抗体的方法; 能够诊断潜伏感染，慢性感染，再感染和/或突破性感染; 并增加低抗病毒抗体水平，以及用于检测低水平表达的病毒特异性抗体的试剂盒。

    METHOD AND KIT FOR THE DETECTION OF HEPATITIS-SPECIFIC ANTIBODIES
    5.
    发明申请
    METHOD AND KIT FOR THE DETECTION OF HEPATITIS-SPECIFIC ANTIBODIES 审中-公开
    用于检测特异性抗原的方法和试剂盒

    公开(公告)号：WO2013132502A1

    公开(公告)日：2013-09-12

    申请号：PCT/IL2013/050217

    申请日：2013-03-07

    Applicant: SMART BIOTECH LTD.

    Inventor： JEHUDA-COHEN, Tamar

    IPC: G01N33/576 ,  C12Q1/70

    CPC classification number: G01N33/576

    Abstract: The present invention relates to an improved method for detecting antibodies to a hepatitis virus in a tissue sample from individuals, which can reliably detect antibodies in recently infected individuals and which provides much lower false positive results in individuals that have cleared their hepatitis infections. More particularly, the present invention relates to an improved method and kit which utilizes an activator of (i) hepatitis virus-primed lymphocytes, (ii) memory cells specific for said hepatitis virus, (iii) hepatitis virus-specific antibody production, or (iv) a combination thereof in a tissue sample to stimulate the production of antibodies from newly primed B cells, if present.

    Abstract translation: 本发明涉及一种用于检测来自个体的组织样品中的肝炎病毒抗体的改进方法，其可以可靠地检测最近感染的个体中的抗体，并且在清除了其肝炎感染的个体中提供了更低的假阳性结果。 更具体地，本发明涉及利用（i）肝炎病毒引发的淋巴细胞的激活剂，（ii）对所述肝炎病毒特异性的记忆细胞，（iii）肝炎病毒特异性抗体产生或（ iv）组合样品中的组合，以刺激来自新引发的B细胞（如果存在）的抗体的产生。

    METHODS AND KITS FOR THE DETECTION OF AN INFECTION IN SUBJECTS WITH LOW SPECIFIC ANTIBODY LEVELS
    6.
    发明申请
    METHODS AND KITS FOR THE DETECTION OF AN INFECTION IN SUBJECTS WITH LOW SPECIFIC ANTIBODY LEVELS 审中-公开
    用于检测具有低特异性抗体水平的受试者感染的方法和工具

    公开(公告)号：WO2012032512A2

    公开(公告)日：2012-03-15

    申请号：PCT/IL2011/000712

    申请日：2011-09-07

    Applicant: SMART BIOTECH LTD. ,  JEHUDA-COHEN, Tamar

    Inventor： JEHUDA-COHEN, Tamar

    IPC: C12Q1/70

    CPC classification number: G01N33/56983 ,  G01N33/576 ,  G01N2333/15 ,  G01N2469/20 ,  Y02A50/54

    Abstract: This invention relates to methods that enable the detection of antibodies against a latent infection, a chronic infection, a re-infection, and/or a breakthrough infection; enable the diagnosis of a latent infection, a chronic infection, a re-infection, and/or a breakthrough infection; and increase low anti-viral antibody levels, and a kit for the detection of virus-specific antibodies expressed at low levels.

    Abstract translation: 本发明涉及能够检测抗潜伏感染，慢性感染，再感染和/或突破性感染的抗体的方法。 能够诊断潜伏感染，慢性感染，再感染和/或突破感染; 并增加低抗病毒抗体水平，以及用于检测低水平表达的病毒特异性抗体的试剂盒。

    METHOD AND KIT FOR THE DETECTION OF HEPATITIS-SPECIFIC ANTIBODIES
    8.
    发明申请
    METHOD AND KIT FOR THE DETECTION OF HEPATITIS-SPECIFIC ANTIBODIES 有权
    用于检测特异性抗原的方法和试剂盒

    公开(公告)号：US20150111767A1

    公开(公告)日：2015-04-23

    申请号：US14383574

    申请日：2013-03-07

    Applicant: SMART Biotech Ltd.

    Inventor： Tamar Jehuda-Cohen

    IPC: G01N33/576

    CPC classification number: G01N33/576

    Abstract: The present invention relates to an improved method for detecting antibodies to a hepatitis virus in a tissue sample from individuals, which can reliably detect antibodies in recently infected individuals and which provides much lower false positive results in individuals that have cleared their hepatitis infections. More particularly, the present invention relates to an improved method and kit which utilizes an activator of (i) hepatitis virus-primed lymphocytes, (ii) memory cells specific for said hepatitis virus, (iii) hepatitis virus-specific antibody production, or (iv) a combination thereof in a tissue sample to stimulate the production of antibodies from newly primed B cells, if present.

    Abstract translation: 本发明涉及一种用于检测来自个体的组织样品中的肝炎病毒抗体的改进方法，其可以可靠地检测最近感染的个体中的抗体，并且在清除了其肝炎感染的个体中提供了更低的假阳性结果。 更具体地，本发明涉及利用（i）肝炎病毒引发的淋巴细胞的激活剂，（ii）对所述肝炎病毒特异性的记忆细胞，（iii）肝炎病毒特异性抗体产生或（ iv）组合样品中的组合，以刺激来自新引发的B细胞（如果存在）的抗体的产生。

    METODO Y EQUIPO PARA ESTIMAR INCIDENCIA DE VIRUS DE INMUNODEFICIENCIA HUMANA (VIH).
    10.
    发明专利
    METODO Y EQUIPO PARA ESTIMAR INCIDENCIA DE VIRUS DE INMUNODEFICIENCIA HUMANA (VIH). 未知

    公开(公告)号：MX2013010924A

    公开(公告)日：2014-11-10

    申请号：MX2013010924

    申请日：2012-03-22

    Applicant: SMART BIOTECH LTD

    Inventor： JEHUDA-COHEN TAMAR

    IPC: G01N33/569

    Abstract: La presente invención proporciona un método para determinar la incidencia de infecciones por virus de inmunodeficiencia humana (VIH) en una población, que comprende comparar los niveles de anticuerpo anti-VIH de muestras de tejido simulado in vitro con aquellos de muestras de tejido no estimulado de miembros individuales de dicha población y equipos relacionados. La presente invención también proporciona un método para determinar la distribución de infecciones por virus de inmunodeficiencia humana (VIH) de etapa reciente, no reciente, y tardía en una población que comprende comparar la inmunoreactividad anti-VIH estimulada in vitro y la inmunoreactividad anti-VIH no estimulada en muestras de tejido de miembros individuales de dicha población y equipos relacionados.

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