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    ATOM TRANSFER RADICAL POLYMERIZATION PROCESS
    1.
    发明申请
    ATOM TRANSFER RADICAL POLYMERIZATION PROCESS 审中-公开
    原子转移自由基聚合方法

    公开(公告)号：WO2005087819A1

    公开(公告)日：2005-09-22

    申请号：PCT/US2005/007265

    申请日：2005-03-07

    Applicant: CARNEGIE MELLON UNIVERSITY ,  MATYJASZEWSKI, Krzysztof ,  BOMBALSKI, Lindsay ,  JAKUBOWSKI, Wojciech ,  MIN, Ke ,  SPANSWICK, James ,  TSAREVSKY, Nicolay

    Inventor： MATYJASZEWSKI, Krzysztof ,  BOMBALSKI, Lindsay ,  JAKUBOWSKI, Wojciech ,  MIN, Ke ,  SPANSWICK, James ,  TSAREVSKY, Nicolay

    IPC: C08F4/06

    CPC classification number: C08F265/04 ,  C08F4/40 ,  C08F220/18 ,  C08F265/00 ,  C08F291/00 ,  C08F293/00 ,  C08F293/005 ,  C08F2438/01

    Abstract: Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprise reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.

    Abstract translation: 本发明的聚合方法的实施方案涉及在最初包含至少一种过渡金属催化剂和原子转移自由基聚合引发剂的聚合介质的存在下使可自由基聚合的单体聚合。 聚合介质可另外包含还原剂。 还原剂可以以连续或间歇的方式最初或在聚合过程中加入。 聚合方法还可包括使还原剂与氧化态的至少一种过渡金属催化剂和包含可自由基转移的原子或基团的化合物反应，以形成不显着控制聚合方法的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和包含可自由基转移的原子或基团的化合物中的至少一种反应，以在整个聚合过程中引发和/或维持催化活性。

    DEGRADABLE POLYMERS
    4.
    发明申请
    DEGRADABLE POLYMERS 审中-公开

    公开(公告)号：WO2004087777A3

    公开(公告)日：2004-10-14

    申请号：PCT/US2004/009905

    申请日：2004-03-29

    Applicant: CARNEGIE MELLON UNIVERSITY ,  MATYJASZEWSKI, Kryzysztof ,  CHUNG, Im, Sik ,  HUANG, Jinyu ,  SARBU, Traian ,  SIEGWART, Daniel, J. ,  SPANSWICK, James ,  TSAREVSKY, Nicolay, V.

    Inventor： MATYJASZEWSKI, Kryzysztof ,  CHUNG, Im, Sik ,  HUANG, Jinyu ,  SARBU, Traian ,  SIEGWART, Daniel, J. ,  SPANSWICK, James ,  TSAREVSKY, Nicolay, V.

    IPC: C08F220/36

    Abstract: Polymers comprising a polymer backbone comprising one or more degradable units are described. The polymer may additionally comprise two or more polymer segments comprising radically (co)polymerizable vinyl monomer units. The degradable units may be independently selected from, but not limited to, at least one of hydrodegradable, photodegradable and biodegradable units between the polymer segments and dispersed along the polymer backbone. The degradable units may be derived from one or more monomers comprising a heterocyclic ring that is capable of undergoing radical ring opening polymerization, a coupling agent, or from a polymerization initiator, radically polymerizable monomers, as well as other reactive sources. Embodiments of the degradable polymer of claim are capable of degrading by at least one of a hydrodegradation, photodegradation or biodegradation mechanisms to form at least one of telechelic oligomer and telechelic polymeric fragments of the polymer. The degradable polymer may be able to degrade into polymer fragments having a molecular weight distribution of less than 5, or in certain applications it may be preferable for embodiments of the polymer to be capable of forming polymer fragments having a molecular weight distribution of the polymer fragments less than 3.0 or even less than 2.5. Embodiments of the present invention also include methods of producing degradable polymers.

    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK
    6.
    发明申请
    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK 审中-公开
    双交联网络制备功能凝胶颗粒

    公开(公告)号：WO2008057163A3

    公开(公告)日：2008-07-24

    申请号：PCT/US2007021684

    申请日：2007-10-09

    Applicant: UNIV CARNEGIE MELLON ,  MATYJASZEWSKI KRZYSZTOF ,  SPANSWICK JAMES ,  MIN KE ,  TSAREVSKY NICOLAY V ,  OH JUNG KWON

    Inventor： MATYJASZEWSKI KRZYSZTOF ,  SPANSWICK JAMES ,  MIN KE ,  TSAREVSKY NICOLAY V ,  OH JUNG KWON

    IPC: C08F293/00 ,  A61K47/32

    CPC classification number: C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

    Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

    Abstract translation: 公开了由交联聚合物网络形成的功能性凝胶颗粒，所述交联聚合物网络包括一部分稳定的交联和第二部分的可切割交联。 功能性化合物可以通过选择性切割可切割的交联物而化学地或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 凝胶颗粒表面上的外周或其它可接近的官能团允许附着表面反应剂，从而改变凝胶颗粒的一种或多种表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至目标部位的方法。

    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK
    7.
    发明申请
    PREPARATION OF FUNCTIONAL GEL PARTICLES WITH A DUAL CROSSLINK NETWORK 审中-公开
    功能性凝胶颗粒与双交联网络的制备

    公开(公告)号：WO2008057163A2

    公开(公告)日：2008-05-15

    申请号：PCT/US2007/021684

    申请日：2007-10-09

    Applicant: CARNEGIE MELLON UNIVERSITY ,  MATYJASZEWSKI, Krzysztof ,  SPANSWICK, James ,  MIN, Ke ,  TSAREVSKY, Nicolay, V. ,  OH, Jung, Kwon

    Inventor： MATYJASZEWSKI, Krzysztof ,  SPANSWICK, James ,  MIN, Ke ,  TSAREVSKY, Nicolay, V. ,  OH, Jung, Kwon

    CPC classification number: C08F293/005 ,  C08F283/00 ,  C08F290/00 ,  C08F290/06 ,  C08F291/00

    Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.

    Abstract translation: 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。

    PREPARATION OF ALKOXYAMINES
    8.
    发明申请
    PREPARATION OF ALKOXYAMINES 审中-公开

    公开(公告)号：WO2007059350A3

    公开(公告)日：2007-05-24

    申请号：PCT/US2006/044931

    申请日：2006-11-17

    Applicant: CARNEGIE MELLON UNIVERSITY ,  MATYJASZEWSKI, Krzysztof ,  SPANSWICK, James

    Inventor： MATYJASZEWSKI, Krzysztof ,  SPANSWICK, James

    IPC: C07C213/06 ,  C07C219/06

    Abstract: Embodiments of the process for the preparation of alkoxyamines of the present invention are directed to conducting a coupling reaction in a reaction medium initially comprising at least one transition metal catalyst, an ATRP initiator and a nitroxide or nitroxide precursor. The reaction medium may additionally comprise a reducing agent. In certain embodiments the reducing agent is the nitroxide precursor. The reducing agent may be added initially or during the coupling process in a continuous or intermittent manner. The coupling process may further comprises reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state further comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the coupling process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and an ATRP initiator to initiate and/or maintain catalytic activity throughout the coupling process between the formed radical and added nitroxide.

    PREPARATION OF ALKOXYAMINES
    10.
    发明申请
    PREPARATION OF ALKOXYAMINES 审中-公开
    烷基胺的制备

    公开(公告)号：WO2007059350A2

    公开(公告)日：2007-05-24

    申请号：PCT/US2006044931

    申请日：2006-11-17

    Applicant: UNIV CARNEGIE MELLON ,  MATYJASZEWSKI KRZYSZTOF ,  SPANSWICK JAMES

    Inventor： MATYJASZEWSKI KRZYSZTOF ,  SPANSWICK JAMES

    CPC classification number: C07C239/20

    Abstract: Embodiments of the process for the preparation of alkoxyamines of the present invention are directed to conducting a coupling reaction in a reaction medium initially comprising at least one transition metal catalyst, an ATRP initiator and a nitroxide or nitroxide precursor. The reaction medium may additionally comprise a reducing agent. In certain embodiments the reducing agent is the nitroxide precursor. The reducing agent may be added initially or during the coupling process in a continuous or intermittent manner. The coupling process may further comprises reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state further comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the coupling process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and an ATRP initiator to initiate and/or maintain catalytic activity throughout the coupling process between the formed radical and added nitroxide.

    Abstract translation: 制备本发明的烷氧基胺的方法的实施方案涉及在最初包含至少一种过渡金属催化剂，ATRP引发剂和氮氧化物或氮氧化物前体的反应介质中进行偶联反应。 反应介质可另外包含还原剂。 在某些实施方案中，还原剂是氮氧化物前体。 还原剂可以以连续或间歇的方式最初或在偶联过程中加入。 偶联方法还可以包括使还原剂与至少一种过渡金属催化剂以氧化态反应，还包含可自由基转移的原子或基团，以形成不显着控制偶合过程的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和ATRP引发剂中的至少一种反应，以在形成的自由基和加入的氮氧化物之间的整个偶联过程中引发和/或维持催化活性。

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