公开(公告)号：WO2022013408A2

公开(公告)日：2022-01-20

申请号：PCT/EP2021/069897

申请日：2021-07-15

Applicant: MERCK SHARP & DOHME CORP. ,  MSD R&D INNOVATION CENTRE LIMITED ,  ALTMAN, Michael ,  CANDITO, David, A. ,  CHRISTIAN, Alec, H. ,  DI PIETRO, Ornella ,  LU, Min ,  LUI, Ping ,  MANSOOR, Umar, Faruk ,  MENNIE, Katrina, Marie ,  MUSACCHIO, Andrew, J. ,  PALANI, Anandan ,  REUTERSHAN, Michael, H. ,  SHAW, David, Matthew ,  ST-GALLAY, Stephen

Inventor： ALTMAN, Michael ,  CANDITO, David, A. ,  CHRISTIAN, Alec, H. ,  DI PIETRO, Ornella ,  LU, Min ,  LIU, Ping ,  MANSOOR, Umar, Faruk ,  MENNIE, Katrina, Marie ,  MUSACCHIO, Andrew, J. ,  PALANI, Anandan ,  REUTERSHAN, Michael, H. ,  SHAW, David, Matthew ,  ST-GALLAY, Stephen

IPC: C07C255/46 ,  A61P25/00 ,  C07D205/12 ,  C07D221/20 ,  C07D295/185 ,  C07D307/94 ,  C07D311/96 ,  C07D403/02 ,  C07D413/02 ,  C07D491/048 ,  A61K31/4747 ,  A61K31/277

Abstract: The present invention relates to cyclic cyanoenone derivatives of Formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein R1, R2, R3, R4 and m are as defined herein. The present invention also relates to pharmaceutical compositions comprising the cyclic cyanoenone derivatives of Formula (I) and to their use in therapy.

公开(公告)号：WO2008122765A1

公开(公告)日：2008-10-16

申请号：PCT/GB2008/001171

申请日：2008-04-04

Applicant: ASTRAZENECA AB ,  ASTRAZENECA UK LIMITED ,  HALLAM, Matthew ,  MARTIN, Barrie ,  RAUBO, Piotr ,  ROBERTS, Bryan ,  ST-GALLAY, Stephen ,  WILLIS, Paul

Inventor： HALLAM, Matthew ,  MARTIN, Barrie ,  RAUBO, Piotr ,  ROBERTS, Bryan ,  ST-GALLAY, Stephen ,  WILLIS, Paul

IPC: C07D217/24 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D487/08 ,  A61K31/4353 ,  A61P11/06

CPC classification number: C07D217/24 ,  C07D217/26 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D487/08

Abstract: The present invention relates to isoquinolinone derivatives of formula (I): should be wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract translation: 本发明涉及式（I）的异喹啉酮衍生物：其中R 1，R 2，R 3，R 3， R 4，R 5，R 6和R 7如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：WO2010039079A1

公开(公告)日：2010-04-08

申请号：PCT/SE2009/000432

申请日：2009-10-01

Applicant: ASTRAZENECA AB ,  BROUGH, Stephen, John ,  LUKER, Timothy, Jon ,  ROBERTS, Bryan, Glyn ,  ST-GALLAY, Stephen, Anthony

Inventor： BROUGH, Stephen, John ,  LUKER, Timothy, Jon ,  ROBERTS, Bryan, Glyn ,  ST-GALLAY, Stephen, Anthony

IPC: C07D401/06 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/55 ,  A61P11/06 ,  C07D217/24

CPC classification number: C07D401/12 ,  C07D217/24 ,  C07D401/06

Abstract: The present invention relates to isoquinolinone derivatives of formula (I): wherein are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract translation: 本发明涉及式（I）的异喹啉酮衍生物：其中如本文所定义; 其制备方法，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：WO0119828A3

公开(公告)日：2001-10-04

申请号：PCT/US0025357

申请日：2000-09-15

Applicant: BASF AG ,  HIRST GAVIN C ,  RAFFERTY PAUL ,  RITTER KURT ,  CALDERWOOD DAVID ,  TWIGGER HELEN L ,  ST GALLAY STEPHEN

Inventor： HIRST GAVIN C ,  RAFFERTY PAUL ,  RITTER KURT ,  CALDERWOOD DAVID ,  TWIGGER HELEN L ,  ST GALLAY STEPHEN

IPC: A61K31/437 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/55 ,  A61K38/00 ,  A61P1/18 ,  A61P3/10 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P15/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P33/02 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6561 ,  A61K31/4353 ,  A61K31/551 ,  C07D491/04 ,  C07D498/04

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07F9/6561

Abstract: The present invention is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors.

Abstract translation: 本发明涉及可用作激酶抑制剂的本文定义的式（I）化合物。

公开(公告)号：IL201015D0

公开(公告)日：2010-05-17

申请号：IL20101509

申请日：2009-09-17

Applicant: ASTRAZENECA AB ,  ROBERTS BRYAN ,  WILLIS PAUL ,  HALLAM MATTHEW ,  MARTIN BARRIE ,  RAUBO PIOTR ,  ST GALLAY STEPHEN

IPC: C07D20100101

Abstract: The present invention relates to isoquinolinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.