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    METHODS FOR INHIBITING TGF-
    2.
    发明公开
    METHODS FOR INHIBITING TGF- 有权
    用于抑制TGF-β

    公开(公告)号：EP2192904A1

    公开(公告)日：2010-06-09

    申请号：EP08798785.5

    申请日：2008-08-27

    Applicant: Auxagen, Inc. ,  St. Louis University

    Inventor： HUANG, Shuan, Shian ,  HUANG, Jung, San

    IPC: A61K31/56 ,  C07J9/00

    CPC classification number: A61K31/56

    Abstract: The present invention provides methods for inhibiting or blocking TGF-β activity in cells and/or tissues expressing TGF-β comprising, contacting cells and/or tissues expressing TGF-β with an amount of cholesterol or cholesterol derivative effective to inhibit the activity of TGF-β. The present invention further provides a method for treating a condition associated with overactivity of TGF-β or negative regulation in normal physiology by TGF-β in a subject in need of treatment, comprising contacting cells and/or tissue overexpressing TGF-β in the subject with an amount of cholesterol or cholesterol derivative effective to inhibit activity of TGF-β thereby treating the condition. In a preferred embodiment, the cholesterol derivative is oxidized 7-DHC.

    Surgical navigation systems including reference and localization frames
    6.
    发明公开
    Surgical navigation systems including reference and localization frames 失效
    Chirurgische Navigationsanordnung einschliesslich Referenz- und Ortungssystemen

    公开(公告)号：EP0950379A2

    公开(公告)日：1999-10-20

    申请号：EP99114109.4

    申请日：1995-10-05

    Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES

    Inventor： The designation of the inventor has not yet been filed

    IPC: A61B19/00

    CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

    Abstract: The invention is a device (300; 350; 400; 500) for use with a surgical navigation system having a sensor array (110; 112) which is in communication with the device (300; 350; 400; 500) to identify its position. The device (300; 350; 400; 500) is for guiding an instrument for engaging a body part thereby locating the instrument at a known position relative to the body part. It has a connector (340; 370; 408; 514) for engaging a cable connected to the surgical navigation system, the cable for providing signals for activating the device (300; 350; 400; 500). The device (300; 350; 400; 500) comprises:

    a housing (308, 310) having a cavity (312; 514) therein;
    a structure (304; 354; 404; 508) on the housing (308, 310) for guiding the instrument in order to maintain the instrument in a relationship relative to the housing (308, 310);
    a plurality of light emitting diodes (316; 510) on the housing (308, 310), said diodes (316; 510), when activated, emitting light for communicating with the sensor array (110; 112) of the surgical navigation system;
    a connector (340; 370; 408; 514) attached to the housing (308, 310) and adapted to engage the cable connected to the surgical navigation system, said connector (340; 370; 408; 514) for receiving the signals for activating the diodes (316; 510); and
    wires (314; 410; 516) located in the cavity (312; 514) of the housing (308, 310) and electrically interconnecting the connector (340; 370; 408; 514) and the light emitting diodes (316; 510) and for transmitting the signals received by the connector (340; 370; 408; 514) to the diodes (316; 510) to activate the diodes (316; 510).

    Abstract translation: 本发明是一种与具有传感器阵列（110; 112）的手术导航系统一起使用的装置（300; 350; 400; 500），该传感器阵列与装置（300; 350; 400; 500）连通以识别其位置 。 装置（300; 350; 400; 500）用于引导用于接合身体部位的器械，从而将器械相对于身体部位定位在已知位置。 其具有用于接合连接到外科导航系统的电缆的连接器（340; 370; 408; 514），所述电缆用于提供用于启动装置（300; 350; 400; 500）的信号。 所述装置（300; 350; 400; 500）包括：其中具有空腔（312; 514）的壳体（308,310） 在所述壳体（308,310）上的结构（304,354; 404; 508），用于引导所述仪器以便将所述仪器保持在与所述壳体（308,310）相关的关系中; 所述壳体（308,310）上的多个发光二极管（316; 510），当被激活时，所述二极管（316; 510）发射用于与外科导航系统的传感器阵列（110; 112）通信的光; 连接器（340; 370; 408; 514），其连接到所述壳体（308,310）并且适于接合连接到所述外科导航系统的所述电缆，所述连接器（340; 370; 408; 514）用于接收用于激活的信号 二极管（316; 510）; 以及位于所述壳体（308,310）的所述空腔（312; 514）中并将所述连接器（340; 370; 408; 514）和所述发光二极管（316; 510）电连接的导线（314; 410; 516） 并且用于将由连接器（340; 370; 408; 514）接收的信号传输到二极管（316; 510）以激活二极管（316; 510）。

    DISTRACTOR
    9.
    发明公开
    DISTRACTOR 审中-公开
    分心

    公开(公告)号：EP2568895A1

    公开(公告)日：2013-03-20

    申请号：EP11781036.6

    申请日：2011-05-03

    Applicant: St. Louis University

    Inventor： BUCHOLZ, Richard, D.

    IPC: A61B17/34

    CPC classification number: A61B17/0293 ,  A61B17/3439

    Abstract: A surgical distractor for distracting tissue of a patient to access structure underlying the tissue of the patient. The distractor includes a tube having a distal end adapted for insertion in tissue, a proximal end opposite the distal end, an exterior surface adapted for contacting the tissue, and an interior surface opposite the exterior surface defining a hollow interior extending between the distal end and the proximal end for accessing structure underlying the tissue when the distal end is inserted in the tissue. The distractor is adjustable from a reduced configuration, in which the tube has a reduced width sized for inserting the distal end in the tissue, and an expanded configuration, in which the tube has an expanded width greater than the reduced width sized to provide the hollow interior with a size sufficient for accessing the structure underlying the tissue.

    Abstract translation: 一种手术牵引器，用于转移患者的组织以进入患者组织下方的结构。 牵开器包括具有适于插入组织的远端的管，与远端相对的近端，适于接触组织的外表面以及与外表面相对的内表面，所述内表面限定中空内部，所述中空内部在远端和 近端用于当远端插入组织时接近组织下方的结构。 牵开器可从减小的构型（其中管具有尺寸缩小以用于将远端插入组织中）和扩张构造进行调节，其中扩张构型中管的扩张宽度大于缩小宽度尺寸以提供空腔 内部的大小足以进入组织下面的结构。

    Bioanodes for use in biofuel cells
    10.
    发明公开
    Bioanodes for use in biofuel cells 审中-公开
    Biobennstoffzellen的Bioanodenfürdie Anwendung

    公开(公告)号：EP2343765A1

    公开(公告)日：2011-07-13

    申请号：EP10179659.7

    申请日：2003-11-21

    Applicant: ST. LOUIS UNIVERSITY

    Inventor： Minteer, Shelly, D. ,  Akers, Niki, L. ,  Moore, Christine, M.

    IPC: H01M8/16 ,  C12Q1/00

    CPC classification number: H01M8/1023 ,  C12N11/08 ,  C12Q1/004 ,  C12Q1/32 ,  H01M4/90 ,  H01M8/1039 ,  H01M8/1088 ,  H01M8/16 ,  H01M2300/0082 ,  Y02E60/527 ,  Y02P70/56

    Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated Nation(R) polymer membrane and a dehydrogenase incorporated within the treated Nation(R) polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.

    Abstract translation: 公开了包含季铵盐处理的聚合物膜和掺入处理的聚合物中的脱氢酶的生物过程。 脱氢酶催化有机燃料的氧化并降低腺嘌呤二核苷酸。 离子导电聚合物膜与多亚甲基绿色氧化还原聚合物膜并置，其用于电还原腺嘌呤二核苷酸的电氧化。 生物阳极用于燃料电池中以产生高功率密度。

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