公开(公告)号：WO2005005465A2

公开(公告)日：2005-01-20

申请号：PCT/US2004/022734

申请日：2004-07-08

Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  STACY, Sue ,  KRAIG, Ellen

Inventor： STACY, Sue ,  KRAIG, Ellen

IPC: C07K14/00

CPC classification number: A61K39/025 ,  A61K39/07 ,  A61K39/08 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/6031 ,  A61K2039/6037 ,  C07K2319/00

Abstract: The present invention provides a composition comprising a chimeric polypeptide comprising a recall antigen that reactivates memory T cells in a subject and a new antigen that activates naïve B cells in a subject and a composition comprising a nucleic acid encoding a chimeric polypeptide comprising a recall antigen that reactivates memory T cells in a subject and a new antigen that activates naïve B cells in a subject. Further provided are methods of eliciting an immune response, as well as treating and/or preventing disease in subjects in whom the ability to mount an immune response to a new antigen is impaired, by administering the compositions of this invention.

Abstract translation: 本发明提供包含嵌合多肽的组合物，所述嵌合多肽包含重新激活受试者中的记忆T细胞的回收抗原和激活受试者中初始B细胞的新抗原和包含编码包含召回抗原的嵌合多肽的核酸的组合物， 重新激活受试者中的记忆T细胞和激活受试者中初始B细胞的新抗原。 进一步提供的是通过施用本发明的组合物，引发免疫应答以及治疗和/或预防患有对新抗原产生免疫应答能力受损的受试者的疾病的方法。

公开(公告)号：WO2005005465A3

公开(公告)日：2005-03-03

申请号：PCT/US2004022734

申请日：2004-07-08

Applicant: UNIV TEXAS ,  STACY SUE ,  KRAIG ELLEN

Inventor： STACY SUE ,  KRAIG ELLEN

IPC: A61K39/07 ,  A61K39/385 ,  A61K394/39 ,  C12N15/62

CPC classification number: A61K39/025 ,  A61K39/07 ,  A61K39/08 ,  A61K39/385 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/6031 ,  A61K2039/6037 ,  C07K2319/00

Abstract: The present invention provides a composition comprising a chimeric polypeptide comprising a recall antigen that reactivates memory T cells in a subject and a new antigen that activates naïve B cells in a subject and a composition comprising a nucleic acid encoding a chimeric polypeptide comprising a recall antigen that reactivates memory T cells in a subject and a new antigen that activates naïve B cells in a subject. Further provided are methods of eliciting an immune response, as well as treating and/or preventing disease in subjects in whom the ability to mount an immune response to a new antigen is impaired, by administering the compositions of this invention.

Abstract translation: 本发明提供了包含嵌合多肽的组合物，所述嵌合多肽包含使对象中的记忆T细胞再激活的回忆抗原和激活对象中初始B细胞的新抗原，所述组合物包含编码包含回忆抗原的嵌合多肽的核酸， 再激活受试者中的记忆T细胞和激活受试者中幼稚B细胞的新抗原。 进一步提供了通过施用本发明的组合物引发免疫应答以及治疗和/或预防对新抗原产生免疫应答的能力受损的受试者中的疾病的方法。