公开(公告)号：WO2004016151A2

公开(公告)日：2004-02-26

申请号：PCT/US2003/025473

申请日：2003-08-13

Applicant: OSTEOTROPHIN, LLC ,  STEWART, Andrew, F. ,  FIASCHI-TAESCH, Nathalie

Inventor： STEWART, Andrew, F. ,  FIASCHI-TAESCH, Nathalie

IPC: A61B

CPC classification number: C07K14/635 ,  A61K38/29 ,  A61K48/005 ,  C12N15/86 ,  C12N2710/10343 ,  G01N33/74 ,  G01N2333/635

Abstract: The present invention relates to the use of mutants of parathyroid hormone-related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect therapeutic and prophylactic relief for disorders and diseases manifested by activation of smooth muscle that can lead to excessive smooth muscle proliferation. For example, where employed in the vasculature, the inventive method can be used to treat restenosis following angioplasty.

Abstract translation: 本发明涉及使用甲状旁腺激素相关蛋白的突变体来治疗与平滑肌细胞相关的疾病，并且抑制细胞活化和增殖。 该方法可用于多种组织中，以对通过激活平滑肌表现的疾病和疾病进行治疗和预防性缓解，这可导致过度的平滑肌增生。 例如，当在血管系统中使用时，本发明的方法可用于治疗血管成形术后的再狭窄。

公开(公告)号：WO2006033912A3

公开(公告)日：2006-06-29

申请号：PCT/US2005032706

申请日：2005-09-14

Applicant: OSTEOTROPHIN LLC ,  STEWART ANDREW F

Inventor： STEWART ANDREW F

IPC: A61K38/00

CPC classification number: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

Abstract translation: 本文公开了用于预防和治疗由骨质量丢失（包括骨质疏松症）表现的多种哺乳动物疾病的方法。 本发明提供了使用PTHrP或其类似物治疗既有效又安全性提高的代谢性骨病的方法。

公开(公告)号：WO2006033912B1

公开(公告)日：2006-09-08

申请号：PCT/US2005032706

申请日：2005-09-14

Applicant: OSTEOTROPHIN LLC ,  STEWART ANDREW F

Inventor： STEWART ANDREW F

IPC: A61K38/00

CPC classification number: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

Abstract translation: 本文公开了用于预防和治疗由骨量丧失（包括骨质疏松症）表现的多种哺乳动物病症的方法。 本发明提供了使用PTHrP或其类似物治疗既有效又具有增加的安全性的代谢性骨病症的方法。

公开(公告)号：WO2006033912A2

公开(公告)日：2006-03-30

申请号：PCT/US2005/032706

申请日：2005-09-14

Applicant: OSTEOTROPHIN LLC ,  STEWART, Andrew, F.

Inventor： STEWART, Andrew, F.

IPC: A61K38/18

CPC classification number: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

Abstract translation: 本文公开了用于预防和治疗由骨质量丢失（包括骨质疏松症）表现的多种哺乳动物疾病的方法。 本发明提供了使用PTHrP或其类似物治疗既有效又增加安全性的代谢性骨病的方法。

公开(公告)号：WO2003059291A3

公开(公告)日：2003-07-24

申请号：PCT/US2003/000770

申请日：2003-01-10

Applicant: OSTEOTROPHIN LLC ,  STEWART, Andrew, F.

Inventor： STEWART, Andrew, F.

IPC: A61K38/29

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

公开(公告)号：WO2004016151A3

公开(公告)日：2004-04-29

申请号：PCT/US0325473

申请日：2003-08-13

Applicant: OSTEOTROPHIN LLC ,  STEWART ANDREW F ,  FIASCHI-TAESCH NATHALIE

Inventor： STEWART ANDREW F ,  FIASCHI-TAESCH NATHALIE

IPC: A61B20060101 ,  A61K38/00 ,  A61K38/29 ,  A61K39/395 ,  A61K48/00 ,  C07K14/00 ,  C07K14/575 ,  C07K14/635 ,  C07K16/26 ,  C07K16/46 ,  C12N5/00 ,  C12N7/00 ,  C12N15/00 ,  C12N15/09 ,  C12N15/861 ,  G01N33/53 ,  G01N33/74

CPC classification number: C07K14/635 ,  A61K38/29 ,  A61K48/005 ,  C12N15/86 ,  C12N2710/10343 ,  G01N33/74 ,  G01N2333/635

Abstract: The present invention relates to the use of mutants of parathyroid hormone-related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect therapeutic and prophylactic relief for disorders and diseases manifested by activation of smooth muscle that can lead to excessive smooth muscle proliferation. For example, where employed in the vasculature, the inventive method can be used to treat restenosis following angioplasty.

Abstract translation: 本发明涉及甲状旁腺激素相关蛋白突变体的用途，用于治疗与平滑肌细胞相关的病症并抑制其细胞活化和增殖。 该方法可用于不同的组织中，以治疗和预防由可导致过度平滑肌增殖的平滑肌活化表现的病症和疾病。 例如，在脉管系统中使用的情况下，本发明的方法可用于治疗血管成形术后的再狭窄。

公开(公告)号：WO2003059291A2

公开(公告)日：2003-07-24

申请号：PCT/US2003/000770

申请日：2003-01-10

Applicant: OSTEOTROPHIN LLC ,  STEWART, Andrew, F.

Inventor： STEWART, Andrew, F.

IPC: A61K

CPC classification number: A61K38/29 ,  A61K2300/00

Abstract: Disclosed herein are methods for the prevention and treatment of a variety of mammalian conditions manifested by loss of bone mass, including osteoporosis. The present invention provides methods of using PTHrP, or analogs thereof, for the treatment of metabolic bone disorders that are both effective and have an increased safety.

Abstract translation: 本文公开了用于预防和治疗由骨量丧失（包括骨质疏松症）表现的多种哺乳动物病症的方法。 本发明提供了使用PTHrP或其类似物治疗既有效又具有增加的安全性的代谢性骨病症的方法。