公开(公告)号：IL266977B2

公开(公告)日：2024-01-01

申请号：IL26697719

申请日：2019-05-29

Applicant: PURDUE RESEARCH FOUNDATION ,  PHILIP S LOW ,  STEWART ANDREW LOW ,  JEFFREY NIELSEN

IPC: A61K31/197 ,  A61K31/663 ,  A61K38/00 ,  A61K47/54 ,  A61K47/64 ,  C07K14/635

Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration

公开(公告)号：IL266977D0

公开(公告)日：2019-07-31

申请号：IL26697719

申请日：2019-05-29

Applicant: PURDUE RESEARCH FOUNDATION ,  PHILIP S LOW ,  STEWART ANDREW LOW ,  JEFFREY NIELSEN

IPC: A61K20060101

Abstract: Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration