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公开(公告)号：JPS5248899A
公开(公告)日：1977-04-19
申请号：JP10540176
申请日：1976-09-02
Applicant: STEWART JOHN S
Inventor： JIYON ESU SUCHIYUWAATO
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公开(公告)号：EP2895504B1
公开(公告)日：2019-05-08
申请号：EP13837615.7
申请日：2013-09-16
Applicant: Stewart, John M.
Inventor： Stewart, John M.
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公开(公告)号：EP2895504A1
公开(公告)日：2015-07-22
申请号：EP13837615.7
申请日：2013-09-16
Applicant: Stewart, John M.
Inventor： Stewart, John M.
IPC: C07K14/47 , A61K38/17 , A61K8/64 , A61K8/98 , A61P17/00 , A61P17/02 , A61Q19/00 , A61Q19/08 , C07K7/06 , C12N5/071 , C12N5/079
CPC classification number: A61K8/64 , A61K38/08 , A61K38/10 , A61K38/17 , A61K38/1709 , A61Q19/00 , A61Q19/08 , C07K7/06 , C07K14/47 , C07K14/4747
Abstract: Described are methods and uses of TRPV3 agonists for the treatment of conditions associated with TRPV3 pathophysiology such as acne, psoriasis, dermatitis, would healing, the inhibition of hair growth, anxiety or depression. Peptides comprising all or part of the C-terminal portion of soricidin are shown to activate TRPV3 cation channel activity and/or promote wound healing in keratinocytes.
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公开(公告)号：EP1601691A2
公开(公告)日：2005-12-07
申请号：EP03775022.1
申请日：2003-11-18
Applicant: Stewart, John M. , steeves, Bradley J. , Vernes, Karl
Inventor： Stewart, John M. , steeves, Bradley J. , Vernes, Karl
Abstract: The invention relates to a low molecular weight peptide (or suite of related peptides) isolated from the submaxiliary saliva glands of shrews of the species Blarina as a paralytic agent. This novel paralytic agent is useful as a neuromuscular blocker and analgesic.
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公开(公告)号：EP0225386A4
公开(公告)日：1991-02-22
申请号：EP86904509
申请日：1986-06-11
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M
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Patent Agency Ranking
公开(公告)号：EP0225386A1
公开(公告)日：1987-06-16
申请号：EP86904509.0
申请日：1986-06-11
Applicant: STEWART, John M. , VAVREK, Raymond J.
Inventor： STEWART, John M. , VAVREK, Raymond J.
Abstract: Le remplacement de la L-Pro à la position 7 du peptide hormonal bradyquinine ou d'autres analogues substitués de la bradyquinine par un acide aminé aromatique de configuration D transforme les agonistes de la bradyquinine en un antagoniste de la bradyquinine. D'autres modifications d'autres positions dans ces antagonistes novateurs de la bradyquinine modifiée en position 7 augmentent la résistance aux enzymes, la puissance et/ou la spécificité antagoniste de ces nouveaux antagonistes de la bradyquinine. Les analogues produits sont utiles pour traiter des états pathologiques ou des maladies du corps d'êtres humains et de mammifères dus à un excès de bradyquinine ou de quinines apparentées produites ou injectées, par des piqûres par exemple, dans le corps.
Abstract translation: 用D-构型芳香族氨基酸置换缓激肽激素肽的第7位或舒缓精胺的其它取代类似物的L-Pro，将缓激肽的激动剂转化为缓激肽拮抗剂。 这些新颖的7位修饰的血管舒缓激肽拮抗剂中其他位置的其他修饰增加了这些新型血管舒缓激肽拮抗剂的酶抗性，效力和/或拮抗特异性。 所产生的类似物可用于治疗人体和哺乳动物身体的疾病或疾病，这是由于过量的缓激肽或相关的奎宁产生或注射（例如通过麻点）进入体内。
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公开(公告)号：EP2643213B1
公开(公告)日：2016-09-14
申请号：EP11791172.7
申请日：2011-11-21
Applicant: Stewart, John Ralph III
Inventor： Stewart, John Ralph III
CPC classification number: B64D33/02 , B64D2033/0286 , F16B37/125 , Y10T29/49947
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8.发明公开TRPV3 AGONISTS FOR THE TREATMENT OF SKIN CONDITIONS 审中-公开TRPV3-AGONISTEN ZUR BEHANDLUNG VON HAUTERKRANKUNGEN
公开(公告)号：EP2895504A4
公开(公告)日：2016-06-22
申请号：EP13837615
申请日：2013-09-16
Applicant: STEWART JOHN M
Inventor： STEWART JOHN M
IPC: C07K14/47 , A61K8/64 , A61K8/98 , A61K38/08 , A61K38/10 , A61K38/17 , A61P17/00 , A61P17/02 , A61Q19/00 , A61Q19/08 , C07K7/06 , C12N5/071 , C12N5/079
CPC classification number: A61K8/64 , A61K38/08 , A61K38/10 , A61K38/17 , A61K38/1709 , A61Q19/00 , A61Q19/08 , C07K7/06 , C07K14/47 , C07K14/4747
Abstract: Described are methods and uses of TRPV3 agonists for the treatment of conditions associated with TRPV3 pathophysiology such as acne, psoriasis, dermatitis, would healing, the inhibition of hair growth, anxiety or depression. Peptides comprising all or part of the C-terminal portion of soricidin are shown to activate TRPV3 cation channel activity and/or promote wound healing in keratinocytes.
Abstract translation: 描述了TRPV3激动剂用于治疗与TRPV3病理生理学相关的病症如痤疮，牛皮癣，皮炎，愈合，抑制头发生长，焦虑或抑郁症的方法和用途。 显示包含番茄红素的全部或部分C末端部分的肽激活TRPV3阳离子通道活性和/或促进角质形成细胞中的伤口愈合。
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公开(公告)号：EP0632736B1
公开(公告)日：1998-08-26
申请号：EP92918936.3
申请日：1992-09-10
Applicant: RICHARDS, Brian, John , STEWART, John, Stewart, Simpson
Inventor： RICHARDS, Brian, John , STEWART, John, Stewart, Simpson
IPC: A62B17/04
CPC classification number: A62B17/04
Abstract: Breathing apparatus to provide respiratory protection having an outer hood, an inner hood, a reservoir at positive pressure, a breathable gas source and a conveyance means with one way valves in an open circuit system.
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公开(公告)号：EP0332688A1
公开(公告)日：1989-09-20
申请号：EP88908552.0
申请日：1988-08-29
Applicant: STEWART, John M. , VAVREK, Raymond J.
Inventor： STEWART, John M. , VAVREK, Raymond J.
Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aliphatic, cyclic or aromatic amino acid of the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-posi tion modified bradykinin antagonists including replacement of arginine in the one and nine positions and sequence dele tions analogs and C-terminal and N-terminal extensions, which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.
Abstract translation: L-Pro的在肽激素缓激肽或缓激肽的其它取代的类似物的7位由脂肪族氨基酸，环状或芳族的取代，缓激肽激动剂转换为缓激肽拮抗剂。 本发明进一步涉及对新的7-位修饰的缓激肽拮抗剂内其他位置的进一步修饰，包括在位置1和位置9处置换精氨酸，以及类似物相对于其的延伸。 缺失序列和C和N末端，这增加了新缓激肽拮抗剂的酶抗性，效力和/或拮抗特异性。 产生的类似物可用于治疗哺乳动物的病症和疾病，以及人体中过量缓激肽或相关激肽的产生或注射。
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