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公开(公告)号：EP0225386A4
公开(公告)日：1991-02-22
申请号：EP86904509
申请日：1986-06-11
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M
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公开(公告)号：AU2383188A
公开(公告)日：1989-03-31
申请号：AU2383188
申请日：1988-08-29
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
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公开(公告)号：BR8606723A
公开(公告)日：1987-08-11
申请号：BR8606723
申请日：1986-06-11
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.
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公开(公告)号：ZA87734B
公开(公告)日：1987-10-28
申请号：ZA87734
申请日：1987-02-02
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
IPC: A61K20060101 , C07K20060101 , A61K , C07K
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公开(公告)号：ZA8700734B
公开(公告)日：1987-10-28
申请号：ZA8700734
申请日：1987-02-02
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
IPC: A61K20060101 , C07K20060101 , A61K , C07K
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Patent Agency Ranking
公开(公告)号：AU2425388A
公开(公告)日：1989-03-31
申请号：AU2425388
申请日：1988-08-29
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
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公开(公告)号：FI870621A0
公开(公告)日：1987-02-13
申请号：FI870621
申请日：1987-02-13
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.
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公开(公告)号：FI870621A
公开(公告)日：1987-02-13
申请号：FI870621
申请日：1987-02-13
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.
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公开(公告)号：NO870517L
公开(公告)日：1987-02-10
申请号：NO870517
申请日：1987-02-10
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
IPC: C07K20060101 , C07K
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公开(公告)号：NO870517A
公开(公告)日：1987-02-10
申请号：NO870517
申请日：1987-02-10
Applicant: STEWART JOHN M , VAVREK RAYMOND J
Inventor： STEWART JOHN M , VAVREK RAYMOND J
IPC: C07K20060101 , C07K
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