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    Meniscus prosthesis
    2.
    发明专利
    Meniscus prosthesis 未知

    公开(公告)号：AU2015228989A1

    公开(公告)日：2016-09-22

    申请号：AU2015228989

    申请日：2015-03-10

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN ,  DSM IP ASSETS BV

    Inventor： KOENEN JACOB ,  DAAMEN EDWIN ,  VAN TIENEN TONY ,  BUMA PIETER

    IPC: A61F2/38 ,  A61F2/30

    Abstract: The invention is directed to a meniscus prosthesis comprising an arc-shaped meniscus prosthesis body having a main portion (1) comprising a reinforcing part (2) and two end portions (1A, 1B) comprising fixation parts (2A, 2B), wherein the main portion (1) comprises a part made of a first biocompatible, non- resorbable material extending between the two end portions (1A, 1B), wherein the reinforcing part (2) and the fixation parts (2A, 2B) are made of a second biocompatible, non-resorbable material and wherein the reinforcing part (2) extends between the fixation parts (2A, 2B) and wherein the fixation parts (2A, 2B) have a through hole (3A, 3B), the first biocompatible, non-resorbable material has a tensile modulus of at most 100 MPa as determined by ISO 527-1 and the second biocompatible, non-resorbable material has a tensile modulus of at least 01 MPa as determined by ISO 527-1.

    MENISCUS PROSTHESIS
    3.
    发明申请
    MENISCUS PROSTHESIS 审中-公开

    公开(公告)号：WO2015135907A1

    公开(公告)日：2015-09-17

    申请号：PCT/EP2015/054906

    申请日：2015-03-10

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN ,  DSM IP ASSETS B.V.

    Inventor： KOENEN, Jacob ,  DAAMEN, Edwin ,  VAN TIENEN, Tony ,  BUMA, Pieter

    IPC: A61F2/38 ,  A61F2/30

    CPC classification number: A61F2/3872 ,  A61B34/10 ,  A61B2034/108 ,  A61F2/30756 ,  A61F2/30965 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30065 ,  A61F2002/30067 ,  A61F2002/30069 ,  A61F2002/3008 ,  A61F2002/30131 ,  A61F2002/30578 ,  A61F2002/30754 ,  A61F2002/30757

    Abstract: The invention is directed to a meniscus prosthesis comprising an arc-shaped meniscus prosthesis body having a main portion (1) comprising a reinforcing part (2) and two end portions (1A, 1B) comprising fixation parts (2A, 2B), wherein the main portion (1) comprises a part made of a first biocompatible, non- resorbable material extending between the two end portions (1A, 1B), wherein the reinforcing part (2) and the fixation parts (2A, 2B) are made of a second biocompatible, non-resorbable material and wherein the reinforcing part (2) extends between the fixation parts (2A, 2B) and wherein the fixation parts (2A, 2B) have a through hole (3A, 3B), the first biocompatible, non-resorbable material has a tensile modulus of at most 100 MPa as determined by ISO 527-1 and the second biocompatible, non-resorbable material has a tensile modulus of at least 01 MPa as determined by ISO 527-1.

    Abstract translation: 本发明涉及一种弯液面假体，其包括具有包括加强部分（2）的主要部分（1）和包括固定部分（2A，2B）的两个端部部分（1A，1B）的弧形弯月面假体，其中， 主要部分（1）包括在两个端部（1A，1B）之间延伸的第一生物相容不可吸收材料制成的部分，其中加强部分（2）和固定部分（2A，2B）由 第二生物相容性不可再吸收材料，并且其中所述加强部分（2）在所述固定部分（2A，2B）之间延伸，并且其中所述固定部分（2A，2B）具有通孔（3A，3B），所述第一生物相容的， - 可吸收材料具有根据ISO 527-1确定的至多100MPa的拉伸模量，并且第二生物相容性不可再吸收材料的拉伸模量通过ISO 527-1确定为至少01MPa。

    POLYMER SUITABLE FOR USE IN CELL CULTURE
    4.
    发明申请
    POLYMER SUITABLE FOR USE IN CELL CULTURE 审中-公开
    聚合物适用于细胞培养

    公开(公告)号：WO2015007771A1

    公开(公告)日：2015-01-22

    申请号：PCT/EP2014/065233

    申请日：2014-07-16

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN

    Inventor： ROWAN, Alan Edward ,  EKSTEEN AKEROYD, Zaskia Hillet ,  WILSON, Christopher ,  GEUTJES, Petrus Johannes ,  FEITZ, Wouter F.j. ,  OOSTERWIJK, Egbert

    IPC: A61K47/48 ,  C08G73/00 ,  C08G65/325 ,  C08G65/333

    CPC classification number: C12N5/069 ,  C07K5/06026 ,  C08G65/325 ,  C08G65/33324 ,  C08G69/10 ,  C08G69/40 ,  C12N5/0691 ,  C12N2502/28 ,  C12N2533/50

    Abstract: The invention relates to a process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process comprises the steps of: i) copolymerizing - a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and - a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is :500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin- strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol- carboxylic acid coupling resulting in esters linkages and NHS-Ester (N- Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.

    Abstract translation: 本发明涉及一种制备低聚（亚烷基二醇）官能化共聚异氰尿苷的方法，其中该方法包括以下步骤：i）共聚 - 接枝有连接基团的寡（亚烷基二醇）官能化异氰脲酸的第一共聚单体和 - 非接枝的寡（亚烷基二醇）官能化的异氰尿苷的第二共聚单体，其中第一共聚单体和第二共聚单体之间的摩尔比为：500和1:30，和ii）添加间隔单元的反应物和细胞粘附因子 对于由步骤i）获得的共聚物，其中间隔单元由通式ALB表示，其中选择连接基团和基团A进行反应并形成第一偶联，并且选择细胞粘附因子和组B反应并形成 第二耦合，其中所述第一耦合和所述第二耦合独立地选自炔 - 叠氮偶合，二苯并环辛炔 - 叠氮偶联， 基 - 叠氮化物偶联，乙烯基砜 - 硫醇偶联，马来酰亚胺 - 硫醇偶联，甲基丙烯酸甲酯 - 硫醇偶联，醚偶联，硫醚偶联，生物素 - 链霉亲和素偶联，胺 - 羧酸导致酰胺键，醇 - 羧酸偶合，产生酯 连接和NHS-酯（N-羟基琥珀酰亚胺酯） - 胺偶联，其中基团L是在主链中选自C，N，O和S的原子之间具有10-60个键的直链链段。

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