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公开(公告)号：WO2008051310A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/011298
申请日：2007-05-09
Applicant: ADVANCED LIQUID LOGIC, INC. , DUKE UNIVERSITY , PAIK, Philip, Y. , BRAFFORD, Keith, R. , STURMER, Ryan, A. , SMITH, Gregory, F. , POLLACK, Michael, G. , PAMULA, Vamsee, K. , WEST, Richard, M. , SRINIVASAN, Vijay
Inventor： PAIK, Philip, Y. , BRAFFORD, Keith, R. , STURMER, Ryan, A. , SMITH, Gregory, F. , POLLACK, Michael, G. , PAMULA, Vamsee, K. , WEST, Richard, M. , SRINIVASAN, Vijay
IPC: B01D57/00
CPC classification number: B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L7/54 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2200/16 , B01L2300/027 , B01L2300/0819 , B01L2300/089 , B01L2300/1827 , B01L2400/0421 , B01L2400/0427 , B01L2400/0448 , G01N33/49 , G01N2035/1034
Abstract: The present invention relates to systems and methods for controlling droplet movements on a droplet microactuator and a droplet microactuator device, system and method for processing and/or analyzing samples. According to one aspect, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another aspect, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a means for coupling the cartridge to the analyzer unit which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit.
Abstract translation: 本发明涉及用于控制液滴微致动器上的液滴运动的系统和方法以及液滴微致动器装置，用于处理和/或分析样品的系统和方法。 根据一个方面，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中系统被编程和配置为允许用户实现 通过与用户界面交互来进行液滴操作。 根据另一方面，提供一种样品分析器，其包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及用于将盒耦合到分析器单元的装置，其将电子和/或光学对准 在分析器单元上从带有电子或光学接收装置的墨盒输出。
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公开(公告)号：WO2011002957A2
公开(公告)日：2011-01-06
申请号：PCT/US2010/040705
申请日：2010-07-01
Applicant: ADVANCED LIQUID LOGIC, INC. , POLLACK, Michael G. , SRINIVASAN, Vijay , PAMULA, Vamsee K. , BRACKETT, George , BRAFFORD, Keith R. , CLARK, Darius , HUA, Zhishan , NORTON, Scott , SISTA, Ramakrishna , SMITH, Gregory F. , STURMER, Ryan A. , SUDARSAN, Arjun , THWAR, Prasanna , WANG, Tih-Hong , WINGER, Theodore
Inventor： POLLACK, Michael G. , SRINIVASAN, Vijay , PAMULA, Vamsee K. , BRACKETT, George , BRAFFORD, Keith R. , CLARK, Darius , HUA, Zhishan , NORTON, Scott , SISTA, Ramakrishna , SMITH, Gregory F. , STURMER, Ryan A. , SUDARSAN, Arjun , THWAR, Prasanna , WANG, Tih-Hong , WINGER, Theodore
CPC classification number: B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
Abstract: The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
Abstract translation: 本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。 在一个实施例中，本发明提供了有助于三维液滴操作的液滴致动器。 在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。 在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。 在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。 在另一个实施例中，本发明提供一种用于组装液滴致动器的磁性夹紧夹具。 在另一个实施例中，本发明提供了用于与微流体系统组合使用的简单的低成本电源。 在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。 在另一个实施例中，本发明提供使用等离子体处理工艺制造以提高衬底表面能的液滴致动器装置。
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公开(公告)号：WO2010019782A3
公开(公告)日：2010-05-14
申请号：PCT/US2009053725
申请日：2009-08-13
Applicant: STURMER RYAN A , SMITH GREGORY F , FOGLEMAN MICHAEL , BRAFFORD KEITH R , RONGALI SAI RAM , ADVANCED LIQUID LOGIC INC
Inventor： STURMER RYAN A , SMITH GREGORY F , FOGLEMAN MICHAEL , BRAFFORD KEITH R , RONGALI SAI RAM
CPC classification number: G06F19/00 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , F04B17/00 , F04B19/006 , F04B49/065
Abstract: The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided.
Abstract translation: 本发明提供了修改的液滴致动器系统，软件和软件执行的用于液滴致动器操作和液滴致动器系统的方法，其被配置和编程为执行这样的软件。 本发明的软件组件的一个方面是用于微流体系统的每个硬件组件的接口描述文件，该文件允许改变硬件组件，而无需修改用于执行液滴操作协议的程序。 本发明的软件组件的另一个方面是建立微滴执行器配置的电极 - 电极关系和其他方面，其可以在编程微滴操作方案时使用。 本发明的软件组件的另一个方面是预定义的电极元件的物理设计库，其可以在构建电极布局时被液滴致动器设计者使用。 本发明的软件组件的另一方面是包含液滴致动器的物理和电气描述的液滴致动器描述文件。 本发明的软件组件的另一方面是用于确定液滴致动器中的液滴操作路线的路由器组件。 本发明的软件组件的另一个方面是使用三态矢量来在液滴致动器中编程序列。 还提供了其他方面。
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公开(公告)号：WO2010019782A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/053725
申请日：2009-08-13
Applicant: STURMER, Ryan, A. , SMITH, Gregory, F. , FOGLEMAN, Michael , BRAFFORD, Keith, R. , RONGALI, Sai, Ram , ADVANCED LIQUID LOGIC, INC.
Inventor： STURMER, Ryan, A. , SMITH, Gregory, F. , FOGLEMAN, Michael , BRAFFORD, Keith, R. , RONGALI, Sai, Ram
CPC classification number: G06F19/00 , B01F13/0076 , B01L3/502715 , B01L3/502792 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , F04B17/00 , F04B19/006 , F04B49/065
Abstract: The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided.
Abstract translation: 本发明提供了用于在液滴致动器操作中使用的修改的液滴致动器系统，软件和软件执行方法以及配置和编程为执行这样的软件的液滴致动器系统。 本发明的软件组件的一个方面是用于微流体系统的每个硬件组件的接口描述文件，其允许在不修改用于执行液滴操作协议的程序的情况下改变硬件组件。 本发明的软件组件的另一方面是建立电极对电极关系和液滴致动器配置的其他方面，其可以在编程液滴操作协议时使用。 本发明的软件组件的另一方面是预定电极元件的物理设计库，其可以在构建电极的布局时由液滴致动器设计者使用。 本发明的软件组件的另一方面是液滴致动器描述文件，其包含液滴致动器的物理和电气描述。 本发明的软件组件的另一方面是用于确定液滴致动器中的液滴操作路线的路由器组件。 本发明的软件组件的另一方面是使用三态向量来在液滴致动器中编程序列。 还提供了其他方面。
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公开(公告)号：WO2008051310A3
公开(公告)日：2009-04-16
申请号：PCT/US2007011298
申请日：2007-05-09
Applicant: ADVANCED LIQUID LOGIC INC , UNIV DUKE , PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
Inventor： PAIK PHILIP Y , BRAFFORD KEITH R , STURMER RYAN A , SMITH GREGORY F , POLLACK MICHAEL G , PAMULA VAMSEE K , WEST RICHARD M , SRINIVASAN VIJAY
IPC: B01D57/00
CPC classification number: B01F13/0076 , B01F13/0071 , B01L3/502792 , B01L7/52 , B01L7/525 , B01L7/54 , B01L2200/0673 , B01L2200/14 , B01L2200/143 , B01L2200/16 , B01L2300/027 , B01L2300/0819 , B01L2300/089 , B01L2300/1827 , B01L2400/0421 , B01L2400/0427 , B01L2400/0448 , G01N33/49 , G01N2035/1034
Abstract: The present invention relates to systems and methods for controlling droplet movements on a droplet microactuator and a droplet microactuator device, system and method for processing and/or analyzing samples. According to one aspect, a system is provided and includes a controller, a droplet microactuator electronically coupled to the controller, and a display device displaying a user interface electronically coupled to the controller, wherein the system is programmed and configured to permit a user to effect a droplet manipulation by interacting with the user interface. According to another aspect, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a means for coupling the cartridge to the analyzer unit which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit.
Abstract translation: 本发明涉及用于控制液滴微致动器上的液滴运动的系统和方法以及液滴微致动器装置，用于处理和/或分析样品的系统和方法。 根据一个方面，提供了一种系统，其包括控制器，电子耦合到控制器的液滴微致动器以及显示电子耦合到控制器的用户界面的显示设备，其中系统被编程和配置为允许用户实现 通过与用户界面交互来进行液滴操作。 根据另一方面，提供一种样品分析器，其包括分析器单元，其包括电子或光学接收装置，包括独立液滴处理能力的盒，以及用于将盒耦合到分析器单元的装置，其将电子和/或光学对准 在分析器单元上从带有电子或光学接收装置的墨盒输出。
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Patent Agency Ranking
公开(公告)号：WO2008101194A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/054134
申请日：2008-02-15
Applicant: ADVANCED LIQUID LOGIC, INC. , STURMER, Ryan A. , POLLACK, Michael G. , PAMULA, Vamsee K. , SRINIVASAN, Vijay , PAIK, Philip Y.
Inventor： STURMER, Ryan A. , POLLACK, Michael G. , PAMULA, Vamsee K. , SRINIVASAN, Vijay , PAIK, Philip Y.
IPC: G01R5/28
CPC classification number: B01L3/50273 , B01L3/502715 , B01L3/502784 , B01L2200/0605 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2400/0427 , G01N27/22 , G01N27/223 , G01N27/227 , G01N2203/00 , G01V3/02
Abstract: A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode.
Abstract translation: 一种用于检测液滴致动器上电容的方法，电路和装置，特别是用于通过以下步骤来确定液滴致动器上的电极处的液滴的存在，部分存在或不存在：（a）提供液滴致动器，包括：（i） 基板，其包括布置在所述基板上的电极，用于在所述基板的表面上进行液滴操作; （ii）电容检测电路，用于检测一个或多个电极处的液滴操作表面处的电容; （b）在一个或多个电极处检测液滴操作表面处的电容; 和（c）根据电容确定在电极处的液滴操作表面处的液滴的存在，部分存在或不存在。
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公开(公告)号：WO2012037308A2
公开(公告)日：2012-03-22
申请号：PCT/US2011/051691
申请日：2011-09-15
Applicant: ADVANCED LIQUID LOGIC, INC. , FOGLEMAN, Michael , STURMER, Ryan A. , SMITH, Gregory, F.
Inventor： FOGLEMAN, Michael , STURMER, Ryan A. , SMITH, Gregory, F.
IPC: B01J19/00 , G01N27/26 , G01N27/447 , C12Q1/68
CPC classification number: B81B7/02 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2400/0424 , B01L2400/0427 , C12Q1/6825 , G01F22/00 , G01N35/10 , C12Q2527/107 , C12Q2563/159 , C12Q2565/629
Abstract: The present invention is directed to droplet actuator systems, devices, and methods. In one embodiment, a microfluidic article of manufacture is provided. The microfluidic article of manufacture includes a first substrate; a second substrate separated from the first substrate to form a droplet operations gap; gap height setting spacers associated with the first and/or second substrate or situated between the first and second substrates; a spring forcing the second substrate against the gap height setting spacers, thereby establishing a substantially uniform gap height between the first and second substrates; and electrodes associated with the first and/or second substrate and configured to conduct droplet operations in the droplet operations gap.
Abstract translation: 本发明涉及液滴致动器系统，装置和方法。 在一个实施例中，提供了微流体制品。 微流体制品包括第一基底; 与所述第一衬底分离以形成液滴操作间隙的第二衬底; 与第一和/或第二衬底相关联或位于第一和第二衬底之间的间隙高度设置间隔件; 弹簧迫使第二基板抵靠间隙高度设定间隔件，由此在第一和第二基板之间建立基本均匀的间隙高度; 以及与第一和/或第二衬底相关联并且被配置成在液滴操作间隙中传导液滴操作的电极。
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8.发明申请
公开(公告)号：WO2012009320A2
公开(公告)日：2012-01-19
申请号：PCT/US2011043650
申请日：2011-07-12
Applicant: ADVANCED LIQUID LOGIC INC , SRINIVASAN VIJAY , BAUER WILLIAM CRAIG , SMITH GREGORY F , STURMER RYAN A , HUA ZHISHAN , ECKHARDT ALLEN E
Inventor： SRINIVASAN VIJAY , BAUER WILLIAM CRAIG
CPC classification number: C12M1/42 , B01L3/502792 , B01L2200/0647 , B01L2300/0672 , B01L2400/0427 , B01L2400/0439 , B01L2400/088 , C12M47/06 , C12N1/066 , C12N13/00
Abstract: The invention relates to a droplet actuator for conducting droplet operations. The actuator includes a bottom substrate and a top substrate separated from the bottom substrate to form a gap. An arrangement of droplet operations electrodes may be located on a surface of the bottom substrate and/or top substrate. Optionally, a sample reservoir may hold a quantity of a sample fluid containing cells. A disruption device which can take various forms is used to lyse the cells in the sample or in a sample droplet to thereby conduct operations on samples having lysed cells therein.
Abstract translation: 本发明涉及一种用于进行液滴操作的液滴致动器。 致动器包括底部基板和与底部基板分离以形成间隙的顶部基板。 液滴操作电极的布置可以位于底部基板和/或顶部基板的表面上。 任选地，样品储存器可以容纳一定量的含有细胞的样品流体。 可以采用各种形式的破坏装置来裂解样品或样品液滴中的细胞，从而对其中具有裂解细胞的样品进行操作。
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公开(公告)号：WO2011002957A3
公开(公告)日：2011-08-04
申请号：PCT/US2010040705
申请日：2010-07-01
Applicant: ADVANCED LIQUID LOGIC INC , POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
Inventor： POLLACK MICHAEL G , SRINIVASAN VIJAY , PAMULA VAMSEE K , BRACKETT GEORGE , BRAFFORD KEITH R , CLARK DARIUS , HUA ZHISHAN , NORTON SCOTT , SISTA RAMAKRISHNA , SMITH GREGORY F , STURMER RYAN A , SUDARSAN ARJUN , THWAR PRASANNA , WANG TIH-HONG , WINGER THEODORE
CPC classification number: B01L3/502707 , B01F13/0071 , B01F13/0076 , B01L3/0241 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2200/0689 , B01L2300/0819 , B01L2300/0861 , B01L2300/087 , B01L2300/0874 , B01L2300/088 , B01L2300/0883 , B01L2400/0415 , B01L2400/0427 , B01L2400/0442 , B01L2400/0457 , B01L2400/0469 , B01L2400/0622 , B01L2400/0688 , B01L2400/088
Abstract: The invention provides droplet actuator devices for facilitating certain droplet actuated molecular techniques. In one embodiment, the invention provides droplet actuators that facilitate droplet operations in three dimensions. In another embodiment, the invention provides for cost-effective production of droplet actuators. In another embodiment, the invention provides for replacing one or more components of a droplet actuator. In another embodiment, the invention provides droplet actuators using printed conductive inks to form electrodes and/or ground planes. In another embodiment, the invention provides a magnetic clamping fixture for assembling droplet actuators. In another embodiment, the invention provides simple, low cost power sources for use in combination with microfluidic systems. In another embodiment, the invention provides an immunoassay multiplexing platform that uses digital microfluidics and real-time imaging of flash-based chemiluminescent signals. In still another embodiment, the invention provides droplet actuator devices that are fabricated using a plasma treatment process to raise substrate surface energy.
Abstract translation: 本发明提供了用于促进某些液滴致动分子技术的液滴致动器装置。 在一个实施例中，本发明提供了促进三维液滴操作的液滴致动器。 在另一个实施例中，本发明提供了液滴致动器的成本有效的生产。 在另一个实施例中，本发明提供了替换液滴致动器的一个或多个部件。 在另一个实施例中，本发明提供使用印刷导电油墨形成电极和/或接地平面的液滴致动器。 在另一个实施例中，本发明提供了一种用于组装液滴致动器的磁性夹具。 在另一个实施例中，本发明提供了与微流体系统结合使用的简单，低成本的电源。 在另一个实施方案中，本发明提供了使用数字微流体和基于闪光的化学发光信号的实时成像的免疫测定多路复用平台。 在又一个实施例中，本发明提供了使用等离子体处理工艺制造以提高衬底表面能量的液滴致动器装置。
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公开(公告)号：WO2012037308A3
公开(公告)日：2012-06-28
申请号：PCT/US2011051691
申请日：2011-09-15
Applicant: ADVANCED LIQUID LOGIC INC , FOGLEMAN MICHAEL , STURMER RYAN A , SMITH GREGORY F
Inventor： FOGLEMAN MICHAEL , STURMER RYAN A , SMITH GREGORY F
IPC: B01J19/00 , C12Q1/68 , G01N27/26 , G01N27/447
CPC classification number: B81B7/02 , B01L3/502792 , B01L2200/0605 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/089 , B01L2400/0424 , B01L2400/0427 , C12Q1/6825 , G01F22/00 , G01N35/10 , C12Q2527/107 , C12Q2563/159 , C12Q2565/629
Abstract: The present invention is directed to droplet actuator systems, devices, and methods. In one embodiment, a microfluidic article of manufacture is provided. The microfluidic article of manufacture includes a first substrate; a second substrate separated from the first substrate to form a droplet operations gap; gap height setting spacers associated with the first and/or second substrate or situated between the first and second substrates; a spring forcing the second substrate against the gap height setting spacers, thereby establishing a substantially uniform gap height between the first and second substrates; and electrodes associated with the first and/or second substrate and configured to conduct droplet operations in the droplet operations gap.
Abstract translation: 本发明涉及液滴致动器系统，装置和方法。 在一个实施例中，提供微流体制造品。 微流体制品包括第一基底; 从所述第一基板分离以形成液滴操作间隙的第二基板; 与第一和/或第二基底相关联或位于第一和第二基底之间的间隙高度设定间隔物; 弹簧迫使第二基板抵靠间隙高度设定间隔件，从而在第一和第二基板之间建立基本均匀的间隙高度; 以及与第一和/或第二基板相关联并且被配置为在液滴操作间隙中进行液滴操作的电极。
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