1,3-bis-(N-lactamyl) propane and the pharmaceutical and cosmetic use thereof
    4.
    发明授权
    1,3-bis-(N-lactamyl) propane and the pharmaceutical and cosmetic use thereof 有权
    1,3-二 - (N-内酰胺基)丙烷及其药物和化妆品用途

    公开(公告)号:US06497886B1

    公开(公告)日:2002-12-24

    申请号:US09269780

    申请日:1999-04-01

    Abstract: The present invention relates to a 1,3-bis-(N-lactamyl)propane of general formula (I), wherein radicals R1, R2, R3, R4, R5 and R6 independently stand for hydrogen, alkyl, cycloalkyl, aryl or aralkyl and at least one of said radicals does not stand for hydrogen, (NLac) and (NLac′) are the same or different and stand for N-lactamyl radicals. The invention also relates to the use of said substances as a solvent in pharmaceutical and cosmetic agents. Disclosed are novel compounds of formula (I), wherein R1 and methyl and R2-R6 stand for hydrogen.

    Abstract translation: 本发明涉及通式(I)的1,3-双 - (N-内酰胺基)丙烷,其中基团R 1,R 2,R 3,R 4,R 5和R 6独立代表氢,烷基,环烷基,芳基或芳烷基 并且所述基团中的至少一个不代表氢,(NLac)和(NLac')相同或不同,代表N-内酰胺基。 本发明还涉及所述物质作为药物和化妆品中的溶剂的用途。 公开了式(I)的新化合物,其中R1和甲基和R2-R6代表氢。

    Direct tableting auxiliary
    8.
    发明授权
    Direct tableting auxiliary 失效
    直接压片辅助

    公开(公告)号:US5006345A

    公开(公告)日:1991-04-09

    申请号:US284765

    申请日:1988-12-12

    Applicant: Siegfried Lang

    Inventor: Siegfried Lang

    CPC classification number: A61K9/2027 A61K9/2018 A61K9/2095

    Abstract: Direct tableting auxiliaries essentially consists of(A) from 88 to 96% by weight of pulverulent carrier conventionally used for the preparation of tablets and consisting of lactose, or lactose together with not more than the same amount of another carrier,(B) from 2 to 6% by weight of polyvinylpyrrolidone having a K value of from 20 to 40, and(C) from 2 to 10% by weight of crosslinked, insoluble polyvinylpyrrolidone, all percentages being based on the direct tableting auxiliary, and are obtained by spray drying, spray granulation or wet granulation.The novel direct tableting auxiliaries exhibit good flow and good compressibility under low pressure, and the tablets produced using the said auxiliaries possess excellent disintegration properties coupled with great hardness and low abrasion.

    Abstract translation: 直接压片助剂基本上由(A)88至96重量%的常规用于制备片剂的粉状载体,由乳糖或乳糖以及不超过相同量的另一种载体组成的(B)2 至6重量%的K值为20至40的聚乙烯吡咯烷酮,和(C)2至10重量%的交联的不溶性聚乙烯吡咯烷酮,所有百分比基于直接压片助剂,并通过喷雾干燥 ,喷雾造粒或湿法制粒。 新型直接压片助剂在低压下表现出良好的流动性和良好的压缩性,并且使用所述助剂制备的片剂具有优异的崩解性能,同时具有极好的硬度和低的磨损性。

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