公开(公告)号：WO1996011747A2

公开(公告)日：1996-04-25

申请号：PCT/US1995013447

申请日：1995-10-10

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION ,  HEADLEY, Thomas, D. ,  POWERS, Edward, T.

Inventor： TRANSFUSION TECHNOLOGIES CORPORATION ,  HEADLEY, Thomas, D. ,  POWERS, Edward, T.

IPC: B04B05/04

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: A rotor (2a-2e) for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm (31) which defines at least a portion of a variable-volume processing chamber (30), where the fluid is centrifuged. The rotor includes a rigid mounting member (28), to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall (10) which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit (13) or conduits (83, 93, 163, 165, 188) to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure (40, 190, 244) for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate (40), located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes (190), wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves (244) in the boundary wall may be used as the outlet-control structure.

Abstract translation: 一种用于在一定体积范围内收集和离心生物流体的转子（2a-2e）。 转子包括限定至少一部分可变体积的处理室（30）的弹性不透水隔膜（31），其中流体被离心。 转子包括刚性安装构件（28），隔膜安装在该刚性安装构件（28）上并由卡盘保持和旋转。 优选地，该刚性安装构件包括与弹性隔膜一起限定腔室的边界壁（10）。 边界壁可以是基本上无孔的圆形壁，其延伸到处理室的周边，但限定一个开口，优选地在旋转轴线附近，允许导管（13）或导管（83,93,163,165,188） 以便与处理室流体连通。 转子可以包括用于控制液体流出腔室进入管道的单独结构（40,190,244）。 在一个优选实施例中，该出口控制结构是位于处理室内并安装在刚性边界壁附近的穿孔的基本刚性的壁或板（40）。 在替代实施例中，用于控制从处理室到管道的流动的出口控制结构可以包括至少一个管或优选地一组管（190），其中每个管提供腔室和管道之间的流体连通。 在一个优选实施例中，边界壁中的凹槽（244）可用作出口控制结构。

公开(公告)号：WO1996040319A1

公开(公告)日：1996-12-19

申请号：PCT/US1996003018

申请日：1996-03-05

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION

Inventor： TRANSFUSION TECHNOLOGIES CORPORATION ,  KINGSLEY, Gordon, F. ,  HEADLEY, Thomas, D. ,  HALPERN, Lise, N.

IPC: A61M01/36

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a variable-volume rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to seperate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner. The tubing connects the needle (72), the rotor (2a), and the first and second containers (92, 91). With the valving, the tubing is able to permit (i) the flow of whole blood from the needle (72) to the rotor (2a), (ii) the flow of anticoagulant from the first container (92) to the whole blood flowing from the needle to the rotor, (iii) the flow of plasma from the rotor to the first container, and (iv) the flow of red blood cells from the rotor to the second container (91). The motor (50) and the valving are preferably controlled by an electronic controller. Preferably, the system also includes a pump (61), which is also controlled by the controller, and which forces the blood components out of the rotor (2a) to the tubing. The pump is preferably able to draw the whole blood into the rotor.

Abstract translation: 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液后保持血液的可变体积转子（2a） （50），用于使转子旋转以使血液分离成组分，例如血浆和红细胞。 该系统还提供用于收集分离的部件的容器。 在一个优选的实施方式中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在将血浆从红色 血细胞和用于存储分离的红细胞的第二容器（91）。 该系统还包括管（73），其可以具有内置在其中的阀（81）并且可以在外部作用，以便以期望的方式引导血液成分。 管连接针（72），转子（2a）以及第一和第二容器（92,91）。 通过阀门，管道能够允许（i）从针头（72）到转子（2a）的全血流动，（ii）抗凝血剂从第一容器（92）流到全血流动 （iii）从转子到第一容器的等离子体流动，以及（iv）红细胞从转子到第二容器（91）的流动。 电动机（50）和阀门优选地由电子控制器控制。 优选地，该系统还包括泵（61），其也由控制器控制，并且迫使血液成分从转子（2a）流出管道。 泵优选能够将全血吸入转子。

公开(公告)号：EP0839072B1

公开(公告)日：2003-03-12

申请号：EP95939541.9

申请日：1995-10-10

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION ,  Headley, Thomas D. ,  Powers, Edward T.

Inventor： HEADLEY, Thomas D. ,  POWERS, Edward T.

IPC: B04B5/04 ,  A61M1/36

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: A rotor (2a-2e) for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm (31) which defines at least a portion of a variable-volume processing chamber (30), where the fluid is centrifuged. The rotor includes a rigid mounting member (28), to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall (10) which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit (13) or conduits (83, 93, 163, 165, 188) to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure (40, 190, 244) for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate (40), located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes (190), wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves (244) in the boundary wall may be used as the outlet-control structure.

公开(公告)号：EP1306135A2

公开(公告)日：2003-05-02

申请号：EP02079616.5

申请日：1995-10-10

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION

Inventor： Headley, Thomas D. ,  Powers, Edward T.

IPC: B04B5/04 ,  A61M1/36

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: Inter alia, a centrifuge system for accepting a rotor (2a) having a rigid mounting member and an elastic diaphragm (31) attached to the mounting member, the system comprising:

means for holding the rigid mounting member of the rotor and for spinning the rotor around an axis; and
means for changing the pressure of a control fluid adjacent the rotor's diaphragm is disclosed.

Abstract translation: 尤其是用于接收具有刚性安装构件的转子（2a）和安装在安装构件上的弹性隔膜（31）的离心机系统，该系统包括：用于保持转子的刚性安装构件并使转子旋转的装置 绕轴; 并且公开了用于改变与转子隔膜相邻的控制流体的压力的装置。

公开(公告)号：EP1161269A1

公开(公告)日：2001-12-12

申请号：EP00912217.7

申请日：2000-03-14

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION

Inventor： HEADLEY, Thomas, D.

IPC: A61M1/36 ,  A61M1/02 ,  B04B13/00

CPC classification number: B04B13/00 ,  A61M1/0218 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M2202/0427 ,  A61M2202/0429 ,  A61M2205/3389 ,  A61M2205/3393 ,  A61M2202/0071

Abstract: A system for collecting, from whole blood, platelets suspended in plasma. By centrifuging the blood at a high enough rotational speed, the platelets (92) are separated from the plasma (91) and the red blood cells (93). In a preferred embodiment, some of the plasma (91) is removed while the centrifuge is being spun to keep the platelets (92) separated from the plasma (91). Then, the speed of rotation is altered so as to cause the platelets (92) to mix with the remaining plasma (91). The platelets (92) can then be collected with the remaining plasma (91).

公开(公告)号：EP1140246A1

公开(公告)日：2001-10-10

申请号：EP99967647.1

申请日：1999-12-27

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION

Inventor： LAMPHERE, David ,  HEADLEY, Thomas, D. ,  STROHL, Clair, L. ,  MARTIN, Clifford

IPC: A61M1/00 ,  A61M1/36 ,  B01D29/56

CPC classification number: A61M1/3627

Abstract: A reservoir-and-filter system for receiving fluid and for removing impurities from fluid is provided in an embodiment of the invention. The system includes a housing with at least two cavities; a first cavity with at least one unfiltered-fluid inlet and a second cavity with at least one filtrate outlet. In this embodiment, a filter member is disposed so as to separate the cavities. In addition, a filtrous trap is disposed so as to directly accept fluid as it enters the first cavity, filter it, and minimize clogging of the filter member. A coarse filter shroud providing a funnel shape at the opening of a cup-shaped trap is included in a preferred embodiment. In an embodiment, at least one gas outlet adaptable for connection to a vacuum source is associated with the second cavity. A method for removing impurities from blood within an extracorporeal circuit is also provided in a further embodiment.

公开(公告)号：EP0839072A2

公开(公告)日：1998-05-06

申请号：EP95939541.0

申请日：1995-10-10

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION ,  Headley, Thomas D. ,  Powers, Edward T.

Inventor： HEADLEY, Thomas D. ,  POWERS, Edward T.

IPC: A61M1 ,  B04B5 ,  A61M5

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: A rotor (2a-2e) for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm (31) which defines at least a portion of a variable-volume processing chamber (30), where the fluid is centrifuged. The rotor includes a rigid mounting member (28), to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall (10) which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit (13) or conduits (83, 93, 163, 165, 188) to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure (40, 190, 244) for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate (40), located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes (190), wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves (244) in the boundary wall may be used as the outlet-control structure.

Abstract translation: 尤其是用于接收具有刚性安装构件的转子（2a）的离心机系统和安装在安装构件上的弹性膜片（31），该系统包括：用于保持转子的刚性安装构件并使转子旋转的装置 绕轴; 并且公开了用于改变与转子隔膜相邻的控制流体的压力的装置。

公开(公告)号：EP1161270A1

公开(公告)日：2001-12-12

申请号：EP00916414.6

申请日：2000-03-16

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION

Inventor： HEADLEY, Thomas, D.

IPC: A61M1/36

CPC classification number: A61M1/3693 ,  A61M1/0218 ,  A61M1/3633 ,  A61M1/3698

Abstract: A system for processing blood that is simple to implement and that reduces the need for human intervention. The system may be used to collect red blood cells. For such a system, a disposable set may be provided with an inlet port, an RBC container, a centrifuge rotor having a variable total volume, and a WBC filter, along with tubing connecting the port, the container, the rotor and the filter. The filter is located in tubing between the inlet port and the rotor, so that white blood cells are filtered from the blood before it reaches the rotor. A control unit is also provided and includes a spinner in which the rotor may be held, a flow-control arrangement for controlling flow among the various components of the disposable set, and an electronic controller. The whole blood is directed by the flow-control arrangement from the inlet through the filter to the rotor. The rotor includes an elastic diaphragm, and the control unit's flow-control arrangement includes a pump or other device for applying a positive and negative pressure to the rotor's elastic diaphragm. The spinner rotates the rotor so as to separate the whole blood into plasma and RBCs. Preferably, the plasma, is urged out of the rotor first and returned to the donor, while the rotor is still being spun. After the plasma has been removed from the rotor, the RBCs are urged from the rotor to an RBC container.

公开(公告)号：EP0830157A1

公开(公告)日：1998-03-25

申请号：EP96909584.0

申请日：1996-03-05

Applicant: TRANSFUSION TECHNOLOGIES CORPORATION

Inventor： KINGSLEY, Gordon, F. ,  HEADLEY, Thomas, D. ,  HALPERN, Lise, N.

IPC: A61M1 ,  B04B5 ,  A61M5

CPC classification number: B04B5/0428 ,  A61M1/0009 ,  A61M1/0011 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  A61M5/1483 ,  A61M2205/3306 ,  A61M2205/331 ,  A61M2205/3393 ,  B04B5/0442

Abstract: The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a variable-volume rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to seperate into components, for example, plasma and red blood cells. The system also provides for a container for collecting a separated component. In a preferred embodiment two containers are used: the first container (92) for containing an anticoagulant, which is preferably added to the whole blood as it is drawn from the donor, and then for storing the plasma after it has been separated from the red blood cells, and the second container (91) for storing the separated red blood cells. The system further includes tubing (73), which may have valving (81) built into it and which may be acted on externally, so as to direct the blood components in the desired manner. The tubing connects the needle (72), the rotor (2a), and the first and second containers (92, 91). With the valving, the tubing is able to permit (i) the flow of whole blood from the needle (72) to the rotor (2a), (ii) the flow of anticoagulant from the first container (92) to the whole blood flowing from the needle to the rotor, (iii) the flow of plasma from the rotor to the first container, and (iv) the flow of red blood cells from the rotor to the second container (91). The motor (50) and the valving are preferably controlled by an electronic controller. Preferably, the system also includes a pump (61), which is also controlled by the controller, and which forces the blood components out of the rotor (2a) to the tubing. The pump is preferably able to draw the whole blood into the rotor.

Abstract translation: 一种用于从供体（70）收集和处理血液的系统，其中所述系统可以足够紧凑以完全位于供体椅子旁边，并且能够在捐赠者在捐赠者之后仍然休息在椅子中时处理血液 血液。 因此，分离的血液成分（血浆和红细胞）可以在全血抽取后立即存储在其各自的最佳环境中，并且血液不需要被运送回到分离实验室进行处理。 该系统包括用于插入供体的静脉中并将全血通过其中的针（72）（或其他套管状装置），用于在抽取血液之后保持血液的可变体积转子（2a） （50），用于使转子旋转，以使血液分离成组分，例如血浆和红细胞。 该系统还提供用于收集分离的部件的容器。 在一个优选的实施方案中，使用两个容器：用于容纳抗凝血剂的第一容器（92），其优选地从供体抽出时加入到全血中，然后在血浆从红色中分离出后存储 血细胞和用于存储分离的红细胞的第二容器（91）。 系统还包括管（73），其可以具有内置在其中的阀（81）并且可以在外部作用，以便以期望的方式引导血液成分。