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    MULTI-FREQUENCY LOCATING SYSTEMS AND METHODS
    2.
    发明申请
    MULTI-FREQUENCY LOCATING SYSTEMS AND METHODS 审中-公开
    多频定位系统和方法

    公开(公告)号：WO2013074705A3

    公开(公告)日：2014-02-27

    申请号：PCT/US2012065126

    申请日：2012-11-14

    Applicant: OLSSON MARK ,  COX DAVID ,  BENCH STEPHANIE M ,  SOUKUP JAN ,  TURNER TIMOTHY M ,  LEVIN RYAN B ,  MEREWETHER RAY ,  MARTIN MICHAEL J

    Inventor： OLSSON MARK ,  COX DAVID ,  BENCH STEPHANIE M ,  SOUKUP JAN ,  TURNER TIMOTHY M ,  LEVIN RYAN B ,  MEREWETHER RAY ,  MARTIN MICHAEL J

    IPC: G01V3/08

    CPC classification number: G01V3/081 ,  G01R33/10

    Abstract: Multi-frequency buried object location system transmitters and locators are disclosed. A transmitter may generate and provide output signals to a buried object at a plu-rality of frequencies, which may be selected based on a connection type. Corresponding lo-cators may simultaneously receive a plurality of magnetic field signals emitted from the bu-ried object and generate visual and/or audible output information based at least in part on the plurality of received magnetic field signals. The visual and/or audible output may be further based on signals received from a quad-gradient antenna array.

    Abstract translation: 公开了多频埋地物位置系统发射机和定位器。 发射机可以根据连接类型选择频率的频率，产生并提供输出信号到掩埋物体。 相应的引线可以同时接收从所述对象物体发射的多个磁场信号，并且至少部分地基于所述多个接收的磁场信号产生视觉和/或听觉输出信息。 视觉和/或听觉输出可以进一步基于从四梯度天线阵列接收的信号。

    2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS
    4.
    发明申请
    2-AMINOPYRIDINE DERIVATIVES AS GLUCOKINASE ACTIVATORS 审中-公开
    2-氨基吡啶衍生物作为GLUCOKINASE激活剂

    公开(公告)号：WO2008091770A1

    公开(公告)日：2008-07-31

    申请号：PCT/US2008/051194

    申请日：2008-01-16

    Applicant: ARRAY BIOPHARMA INC. ,  AICHER, Thomas Daniel ,  BOYD, Steven Armen ,  CHICARELLI, Mark Joseph ,  CONDROSKI, Kevin Ronald ,  GARREY, Rustam Ferdinand ,  HINKLIN, Ronald Jay ,  SINGH, Ajay ,  TURNER, Timothy M.

    Inventor： AICHER, Thomas Daniel ,  BOYD, Steven Armen ,  CHICARELLI, Mark Joseph ,  CONDROSKI, Kevin Ronald ,  GARREY, Rustam Ferdinand ,  HINKLIN, Ronald Jay ,  SINGH, Ajay ,  TURNER, Timothy M.

    IPC: C07D417/14 ,  C07D495/04 ,  A61K31/4439

    CPC classification number: C07D495/04 ,  C07D417/14

    Abstract: Provided are compounds having the Formula (I) or salts thereof, wherein: L is O, S, SO, SO 2 , CHOH, C(O), or CH 2 ; D 2 is CR 12 or N; R 2 is aryl, heteroaryl, saturated or partially unsaturated cycloalkyl, or saturated or partially unsaturated heterocyclyl (optionally substituted with oxo), wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl are monocyclic or bicyclic and are further optionally substituted with one or more groups independently selected from C 1 -C 6 alkyl, F, Cl, Br, I, CF 3 , CN, OR 6 , C(=O)R 6 , C(=O)OR 6 , O(CH 2 ) n C(=O)OR 6 , C(=O)NR 6 R 7 , NO 2 and (1-6C alkyl)OR 6 ; R 3 is H, Br, OR 6 , SR 6 , C(O)OR 6 , C(O)NR 6 R 7 , C(O)R 6 , heteroaryl, or C 1 -C 6 alkyl substituted with one or more groups independently selected from V n -aryl, V n -OR 6 , V n - C(=O)OR 6 and V n -NR 6 R 7 ; R 11 is H or Cl; and R 13 is N-(1 -6C alkanoyl)piperidin-4-yl; that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

    Abstract translation: 提供具有式（I）或其盐的化合物，其中：L是O，S，SO，SO 2，CHOH，C（O）或CH 2 ; D 是CR 12或N; R 2是芳基，杂芳基，饱和或部分不饱和的环烷基或饱和或部分不饱和的杂环基（任选被氧代取代），其中所述芳基，杂芳基，环烷基和杂环基是单环或双环的， 被一个或多个独立地选自C 1 -C 6烷基，F，Cl，Br，I，CF 3 N，CN， C（= O）R 6，C（= O）OR 6，O（CH 2）2， C（= O）OR 6，C（= O）NR 6 R 7，NO 2和（1-6C烷基）OR 6; R 3是H，Br，OR 6，SR 6，C（O）OR 6，C（O） O）NR 6 R 7，C（O）R 6，杂芳基或C 1 -C 6烷基， 被一个或多个独立地选自以下的基团取代的亚烷基烷基：V n - 芳基，V n -OR 6，V C（= O）OR 6和V 6和-NR 6 R 7， SUP>; R 11是H或Cl; 和R 13是N-（1-6C烷酰基）哌啶-4-基; 其可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病。 还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。

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