公开(公告)号：US20060035980A1

公开(公告)日：2006-02-16

申请号：US11099959

申请日：2005-04-05

Applicant: Thomas Scanlan ,  Matthew Hart ,  David Grandy ,  James Bunzow ,  Motonori Miyakawa ,  Edwin Tan ,  Katherine Suchland

Inventor： Thomas Scanlan ,  Matthew Hart ,  David Grandy ,  James Bunzow ,  Motonori Miyakawa ,  Edwin Tan ,  Katherine Suchland

IPC: A61K31/137 ,  C07C211/27

CPC classification number: C07C217/60 ,  C07C215/52 ,  C07C217/16 ,  C07C217/20 ,  C07C217/54 ,  C07C235/50 ,  C07C235/60 ,  C07C255/37 ,  C07C271/16 ,  C07C271/20

Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

Abstract translation: 公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。 还公开了制备这些化合物的方法。

公开(公告)号：US20070039870A1

公开(公告)日：2007-02-22

申请号：US11206413

申请日：2005-08-18

Applicant: Thomas Scanlan

Inventor： Thomas Scanlan

IPC: B01D35/28

CPC classification number: B01D29/114 ,  B01D29/27 ,  B01D29/52 ,  B01D29/96 ,  B01D2201/307

Abstract: There is provided a liquid filter comprising a filter vessel having a removable cover, a fluid inlet, an engagement lip for a filter and a fluid outlet, an open top, fluid impermeable sidewalls, and a fluid outlet at a bottom of the insert. Into the filter vessel is inserted a water impermeable insert having an insert lip engageable in a sealing relationship with the filter vessel engagement lip. A single cartridge filter is inserted within the cartridge filter insert having a generally solid top surface, a bottom fluid outlet sealingly engageable with the insert outlet and a filter material. The cartridge filter top surface forms a weir for diverting fluid to be filtered toward an annular opening created between the filter cartridge and the insert, the annular opening having a cross sectional area, which generally is from 25 to 100% of the cross sectional area of the filter cartridge outlet opening.

Abstract translation: 提供了一种液体过滤器，其包括具有可移除盖，流体入口，用于过滤器的接合唇和流体出口，开口顶部，流体不可渗透侧壁和在插入件底部的流体出口的过滤器容器。 向过滤器容器中插入具有可与过滤器接合唇缘密封关系的插入唇缘的不透水插入物。 单个筒式过滤器插入到具有大体上固体的顶部表面的盒式过滤器插入件中，底部流体出口可与插入物出口密封地接合并具有过滤材料。 筒式过滤器顶部表面形成用于将待过滤的流体朝向在滤筒和插入件之间产生的环形开口转向的堰，该环​​形开口的横截面积通常为截面面积的25至100％ 滤芯出口开口。

公开(公告)号：US20050267207A1

公开(公告)日：2005-12-01

申请号：US11155345

申请日：2005-06-17

Applicant: Thomas Scanlan ,  Matthew Hart ,  David Grandy ,  James Bunzow

Inventor： Thomas Scanlan ,  Matthew Hart ,  David Grandy ,  James Bunzow

IPC: A61K31/137 ,  A61K31/277 ,  A61K31/35 ,  C07C211/27 ,  C07C233/77 ,  C07C323/32

CPC classification number: C07C215/52 ,  C07C217/16 ,  C07C217/54 ,  C07C235/50 ,  C07C255/37 ,  C07C271/16 ,  C07C271/20

Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

公开(公告)号：US20050054700A1

公开(公告)日：2005-03-10

申请号：US10972250

申请日：2004-10-22

Applicant: Thomas Scanlan ,  Nilesh Shah

Inventor： Thomas Scanlan ,  Nilesh Shah

IPC: C07D231/54 ,  A61K31/415 ,  A61K31/416 ,  A61K31/42 ,  A61K31/423 ,  A61K31/425 ,  A61P3/04 ,  A61P3/10 ,  A61P5/44 ,  A61P5/46 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  C07D275/06 ,  C07D317/72 ,  C07D327/10 ,  C07D339/06 ,  C07D403/06 ,  C07D409/06

CPC classification number: C07D403/06 ,  C07D409/06 ,  C07D487/04

Abstract: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.

Abstract translation: 本发明提供了用于糖皮质激素受体的非甾体配体，用于制备糖皮质激素受体的非甾体配体的方法，糖皮质激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与糖皮质激素受体结合的糖皮质激素相关的疾病（例如，肥胖症，糖尿病，抑郁症，神经变性或炎性疾病）的糖皮质激素受体。

公开(公告)号：US20050113453A1

公开(公告)日：2005-05-26

申请号：US10970242

申请日：2004-10-20

Applicant: Thomas Scanlan ,  Martin Kelly ,  Jian Qiu ,  Sandra Tobias ,  Oline Ronnekleiv

Inventor： Thomas Scanlan ,  Martin Kelly ,  Jian Qiu ,  Sandra Tobias ,  Oline Ronnekleiv

IPC: C07C57/42 ,  C07C59/52 ,  C07C59/64 ,  C07C235/34 ,  A61K31/195 ,  A61K31/137

CPC classification number: C07C235/34 ,  C07C57/42 ,  C07C59/52 ,  C07C59/64

Abstract: The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.

Abstract translation: 本公开涉及一类新的选择性雌激素受体调节剂（SERM）。 本公开还包括鉴定以前未知的膜相关雌激素受体。 公开了制备和使用所公开的SERM的方法，包括所公开的新颖化合物在有用组合物中的药物制剂。

公开(公告)号：US20070049629A1

公开(公告)日：2007-03-01

申请号：US11467908

申请日：2006-08-28

Applicant: Thomas Scanlan ,  Dmitry Kadnikov

Inventor： Thomas Scanlan ,  Dmitry Kadnikov

IPC: A61K31/42 ,  A61K31/416 ,  C07D261/20 ,  C07D231/54

CPC classification number: C07D261/20 ,  C07D231/54 ,  C07D403/06

Abstract: The invention provides non-steroidal ligands for the androgen receptor, methods for making non-steroidal ligands of the androgen receptor, compositions of non-steroidal ligands of the androgen receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the androgen receptor for treating or preventing diseases (e.g., prostate cancer) associated with androgen binding to the androgen receptor.

Abstract translation: 本发明提供用于雄激素受体的非甾体配体，用于制备雄激素受体的非甾体配体的方法，雄激素受体的非甾体配体的组合物和使用非甾体配体的方法和非甾体配体的组合物 用于治疗或预防与雄激素受体结合的雄激素相关的疾病（例如前列腺癌）的雄激素受体。

公开(公告)号：US20050096485A1

公开(公告)日：2005-05-05

申请号：US10825881

申请日：2004-04-16

Applicant: Thomas Scanlan ,  Matthew Hart ,  David Grandy ,  James Bunzow ,  Mononori Miyakawa ,  Edwin Tan ,  Katherine Suchland

Inventor： Thomas Scanlan ,  Matthew Hart ,  David Grandy ,  James Bunzow ,  Mononori Miyakawa ,  Edwin Tan ,  Katherine Suchland

IPC: A61K20060101 ,  A61K31/135 ,  A61K31/137 ,  A61K31/277 ,  A61K31/35 ,  C07C211/27 ,  C07C215/52 ,  C07C215/54 ,  C07C217/20 ,  C07C217/60 ,  C07C233/77 ,  C07C235/50 ,  C07C235/60 ,  C07C323/32

CPC classification number: C07C217/60 ,  C07C215/52 ,  C07C217/16 ,  C07C217/20 ,  C07C217/54 ,  C07C235/50 ,  C07C235/60 ,  C07C255/37 ,  C07C271/16 ,  C07C271/20

Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed

Abstract translation: 公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。 还公开了制备这些化合物的方法