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    AN OPTICAL SYSTEM AND A METHOD FOR REAL-TIME ANALYSIS OF A LIQUID SAMPLE
    4.
    发明申请
    AN OPTICAL SYSTEM AND A METHOD FOR REAL-TIME ANALYSIS OF A LIQUID SAMPLE 审中-公开
    一种液体样品的实时分析系统和方法

    公开(公告)号：WO2014169921A1

    公开(公告)日：2014-10-23

    申请号：PCT/DK2014/050099

    申请日：2014-04-15

    Applicant: UNISENSOR A/S

    Inventor： BERG, Tommy Winther ,  SPILLUM, Erik ,  VALVIK, Martin Christian ,  OLESEN, Tom

    IPC: G01N21/00

    CPC classification number: G01N15/0211 ,  G01N15/0227 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1463 ,  G01N21/07 ,  G01N21/272 ,  G01N21/51 ,  G01N21/53 ,  G01N33/146 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0088 ,  G01N2015/025 ,  G01N2015/0294 ,  G01N2015/0687 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1087 ,  G01N2015/1093 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2201/10

    Abstract: An optical system suitable for determining a characteristic as a function of time of at least a part of a liquid volume comprising a plurality of objects. The optical system provides a fast detection of a change in the liquid volume. The optical system comprises - an optical detection assembly comprising at least one image acquisition device configured to acquire images of an image acquisition area; - a sample device comprising at least one sample container suitable for holding a sample of said liquid volume; - a translating arrangement configured to translate said image acquisition area through at least one part of said sample container to perform a scan along a scanning path through said part of said sample container; and - an image analyzing processing system. The optical system is programmed to perform consecutive scans through said at least one part of said sample container, wherein each scan comprises acquiring images at a plurality of image acquiring positions of the image acquisition area by the optical detection assembly along at least one scanning path of the scan. The image analyzing processing system is programmed to determine a set of features in the form of a set of values for each of a plurality of objects captured on said images from each respective scan and to determine for each scan at least one derived result, the derived result is derived from a plurality of the sets of values, and to present said derived result obtained from the respective, consecutive scans as a function of time.

    Abstract translation: 一种光学系统，适于确定作为包括多个物体的液体体积的至少一部分的时间的函数的特性。 光学系统提供对液体体积变化的快速检测。 光学系统包括 - 光学检测组件，其包括被配置为获取图像获取区域的图像的至少一个图像采集装置; - 样品装置，其包括适于保持所述液体体积的样品的至少一个样品容器; - 翻译装置，被配置为通过所述样本容器的至少一部分来翻译所述图像采集区域，以沿着穿过所述样本容器的所述部分的扫描路径进行扫描; 和 - 图像分析处理系统。 光学系统被编程为通过所述样品容器的所述至少一个部分执行连续的扫描，其中每个扫描包括通过光学检测组件在图像获取区域的多个图像获取位置沿着至少一个扫描路径获取图像 扫描。 图像分析处理系统被编程为以对于从每个相应扫描在所述图像上捕获的多个对象中的每一个的一组值的形式来确定一组特征，并且为每个扫描确定至少一个派生结果，导出 结果是从多组值导出的，并且呈现作为时间的函数的从相应的连续扫描获得的所得到的结果。

    SYSTEM AND METHOD FOR CLASSIFICATION OF PARTICLES IN A FLUID SAMPLE
    6.
    发明申请
    SYSTEM AND METHOD FOR CLASSIFICATION OF PARTICLES IN A FLUID SAMPLE 审中-公开
    用于在流体样品中分类颗粒的系统和方法

    公开(公告)号：WO2014094790A1

    公开(公告)日：2014-06-26

    申请号：PCT/DK2013/050445

    申请日：2013-12-19

    Applicant: UNISENSOR A/S

    Inventor： VALVIK, Martin Christian ,  LARSEN, Niels Agersnap ,  BERG, Tommy Winther

    IPC: G01N15/14 ,  G01N15/02 ,  G01N21/01 ,  G06T7/60

    CPC classification number: G06K9/00147 ,  G01N15/0227 ,  G01N15/1434 ,  G01N15/1475 ,  G01N2015/144 ,  G01N2015/1445 ,  G01N2015/1488 ,  G06K9/00127 ,  G06K9/0014 ,  G06T5/50 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/20084 ,  H04N13/296

    Abstract: A particle classifier system and a method of training the system are described. The particle classifier system is suitable for classification of particles in a liquid sample, said particle classifier system comprises - an optical detection assembly comprising at least one image acquisition device with an optical axis, the image acquisition device is configured to acquire images of an image acquisition area perpendicular to said optical axis; - a sample device comprising at least one sample container suitable for holding a sample in liquid form; - a translating arrangement configured to translate said image acquisition area through at least a part of said sample container; - a control system configured to controlling said optical detection assembly and said translating unit to acquire images of a plurality of image acquisition areas; - an image analyzing processing system programmed to analyze said acquired images by a method comprising creating objects (sub-images) of individual particles captured by said acquired images, creating stacks of objects of each individual particle, identifying complete stacks of objects comprising at least one object wherein said particle is in-focus, and two objects wherein said particle is out-of-focus, and determining, for each of said complete stacks of objects, a set of values for a set of features of at least N features, wherein N is larger than or equal to 1, and wherein the determination of said values of said set of features involve data obtained from said at least one object wherein said particle is in-focus, and/or said at least two objects wherein said particle is out-of-focus; and - an artificial intelligent processing system programmed to associate said set of values for said determined set of features for each individual particle to a particle classification.

    Abstract translation: 描述了一种粒子分类器系统和训练该系统的方法。 所述粒子分级系统适用于液体样品中颗粒的分类，所述粒子分级系统包括 - 光学检测组件，其包括至少一个具有光轴的图像采集装置，所述图像获取装置被配置为获取图像采集的图像 垂直于所述光轴的区域; - 样品装置，其包括至少一个适于保持液体样品的样品容器; - 翻译装置，被配置为通过所述样本容器的至少一部分来翻译所述图像获取区域; - 控制系统，被配置为控制所述光学检测组件和所述平移单元以获取多个图像采集区域的图像; - 图像分析处理系统，被编程为通过包括创建由所述获取的图像捕获的单个粒子的对象（子图像）的方法来分析所述获取的图像，创建每个单独粒子的对象的堆叠，识别包括至少一个 对象，其中所述粒子是聚焦的，以及两个物体，其中所述粒子失焦，并且对于每个所述完整的物体堆，确定至少N个特征的一组特征的一组值，其中 N大于或等于1，并且其中所述特征集合的所述值的确定涉及从所述至少一个物体获得的数据，其中所述粒子在焦点中，和/或所述至少两个物体，其中所述粒子是 外的焦点; 以及 - 人造智能处理系统，其被编程为将用于每个单独粒子的所述确定的特征集合的所述值集合与粒子分类相关联。

    FLEXIBLE SAMPLE CONTAINER
    7.
    发明申请
    FLEXIBLE SAMPLE CONTAINER 审中-公开
    柔性样品容器

    公开(公告)号：WO2011107102A1

    公开(公告)日：2011-09-09

    申请号：PCT/DK2011/050064

    申请日：2011-03-02

    Applicant: UNISENSOR A/S ,  OLESEN, Tom

    Inventor： OLESEN, Tom

    IPC: G01N21/05 ,  B01L3/00 ,  G01N21/85

    CPC classification number: G01N21/05 ,  B01L3/505 ,  B01L2300/0832 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N21/85 ,  G01N2021/0346 ,  G01N2021/0364 ,  G01N2021/8557

    Abstract: The invention relates to a system for holding a fluid sample, said system comprising a transparent flexible tube for holding said fluid sample, a tube holder for holding said tube, a first flattening element, and second flattening element, wherein said first flattening element and said second flattening element may be moved relative to each other thereby changing said transparent flexible tube from a first state to a second state, where at least a first cross sectional dimension of said tube is smaller in said second state than in said first state.

    Abstract translation: 本发明涉及一种用于保持流体样品的系统，所述系统包括用于保持所述流体样品的透明柔性管，用于保持所述管的管保持器，第一平坦化元件和第二压平元件，其中所述第一平坦化元件和所述 第二压平元件可以相对于彼此移动，从而将所述透明柔性管从第一状态改变到第二状态，其中所述管的至少第一横截面尺寸在所述第二状态下小于在所述第一状态。

    SYSTEM AND METHOD FOR TIME-RELATED MICROSCOPY OF BIOLOGICAL ORGANISMS
    8.
    发明申请
    SYSTEM AND METHOD FOR TIME-RELATED MICROSCOPY OF BIOLOGICAL ORGANISMS 审中-公开
    用于生物有机体时间相关显微镜的系统和方法

    公开(公告)号：WO2011066837A1

    公开(公告)日：2011-06-09

    申请号：PCT/DK2010/050327

    申请日：2010-12-01

    Applicant: UNISENSOR A/S ,  OLESEN, Tom ,  VALVIK, Martin Christian ,  LARSEN, Niels Agersnap

    Inventor： OLESEN, Tom ,  VALVIK, Martin Christian ,  LARSEN, Niels Agersnap

    IPC: G02B21/36 ,  G01B9/04 ,  G01N21/00

    CPC classification number: G02B21/0004 ,  C12Q1/18 ,  G02B21/365

    Abstract: The invention relates to a system and a method for determination of a value for at least one parameter describing microbial activity of individual biological organisms in a liquid sample. Images,wherein individual biological organisms may be identified,are combined to provide optical sectionings of the biological organisms and the optical sectionings are analysed to determine the value for said at least one parameter describing microbial activity of said individual biological organisms in each sample container.

    Abstract translation: 本发明涉及用于确定描述液体样品中各种生物体的微生物活性的至少一个参数的值的系统和方法。 组合可以识别个体生物体的图像以提供生物生物体的光学切片，并且分析光学切片以确定描述每个样品容器中所述各个生物体的微生物活性的所述至少一个参数的值。

    OPTICAL SECTIONING OF A SAMPLE AND DETECTION OF PARTICLES IN A SAMPLE
    9.
    发明申请
    OPTICAL SECTIONING OF A SAMPLE AND DETECTION OF PARTICLES IN A SAMPLE 有权
    样品的光学部分和样品中的颗粒检测

    公开(公告)号：US20140347447A1

    公开(公告)日：2014-11-27

    申请号：US14299329

    申请日：2014-06-09

    Applicant: UNISENSOR A/S

    Inventor： Tom OLESEN ,  Martin Christian VALVIK ,  Niels Agersnap LARSEN ,  Rasmus Helmsby SANDBERG

    IPC: G02B21/36 ,  G01N15/14 ,  G02B21/00 ,  G06K9/00 ,  G06T7/00

    CPC classification number: G02B21/367 ,  G01N15/1434 ,  G01N15/1475 ,  G01N17/00 ,  G01N2015/1445 ,  G01N2015/1452 ,  G02B21/002 ,  G06K9/00134 ,  G06T7/0012 ,  G06T2207/10016 ,  G06T2207/10061 ,  G06T2207/30024 ,  G06T2207/30101 ,  H04N13/189 ,  H04N13/239 ,  H04N13/296

    Abstract: An apparatus for obtaining a plurality of images of a sample includes a sample device suitable for holding a liquid sample; a first optical detection assembly including a first image acquisition device, the first optical detection assembly having an optical axis and an object plane, the object plane including an image acquisition area from which electromagnetic waves can be detected as an image by the first image acquisition device; one translation unit arranged to move the sample device and the first optical detection assembly relative to each other; and an image illumination device, wherein the apparatus is arranged to move the sample device and the first optical detection assembly relative to each other along a scanning path, which defines an angle theta relative to the optical axis, wherein theta is in the range of about 0.3 to about 89.7 degrees.

    Abstract translation: 用于获得样品的多个图像的装置包括适于保持液体样品的样品装置; 第一光学检测组件，包括第一图像采集装置，所述第一光学检测组件具有光轴和物体平面，所述物体平面包括图像获取区域，所述第一图像采集装置可以通过所述第一图像获取装置检测电磁波作为图像 ; 一个平移单元，布置成相对于彼此移动样本装置和第一光学检测组件; 以及图像照明装置，其中所述装置被布置成沿着相对于所述光轴限定角度θ的扫描路径相对于彼此移动所述样本装置和所述第一光学检测组件，其中θ在约 0.3至约89.7度。

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