公开(公告)号：AU2014324043B2

公开(公告)日：2019-05-09

申请号：AU2014324043

申请日：2014-08-06

Applicant: UNIV HEALTH NETWORK UHN TECHNOLOGY DEVELOPMENT AND COMMERCIALIZATION

Inventor： MONNIER PHILIPPE P ,  TASSEW NARDOS G

IPC: C07K14/705 ,  A61K31/137 ,  A61K38/17 ,  A61K39/395 ,  A61P9/10 ,  A61P25/00 ,  C07K14/435 ,  G01N33/53

Abstract: Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin.