公开(公告)号：WO2005066368A2

公开(公告)日：2005-07-21

申请号：PCT/US2004/043632

申请日：2004-12-28

Applicant: INTEL CORPORATION ,  BERLIN, Andrew ,  YAMAKAWA, Mineo

Inventor： BERLIN, Andrew ,  YAMAKAWA, Mineo

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q2565/601 ,  C12Q2563/155 ,  C12Q2525/179

Abstract: A method for determining a nucleotide sequence of a nucleic acid is provided that includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, wherein each labeled oligonucleotide includes a known nucleotide sequence and a molecular nanocode. The nanocode of an isolated labeled oligonucleotides that binds to the nucleic acid is then detected using SPM. Nanocodes of the present invention in certain aspects include detectable features beyond the arrangement of tags that encode information about the barcoded object, which assist in detecting the tags that encode information about the barcoded object. The detectable features include structures of a nanocode or associated with a nanocode, referred to herein as detectable feature tags, for error checking/error-correction, encryption, and data reduction/compression.

Abstract translation: 提供了用于确定核酸的核苷酸序列的方法，其包括使核酸与一系列用于结合核酸的标记的寡核苷酸接触，其中每个标记的寡核苷酸包括已知的核苷酸序列和分子纳代码。 然后使用SPM检测与核酸结合的分离的标记寡核苷酸的纳代码。 在某些方面，本发明的纳代码包括超过编码关于条形码对象的信息的标签布置的可检测特征，其有助于检测编码关于条形码对象的信息的标签。 可检测特征包括用于错误校验/纠错，加密和数据缩减/压缩的纳代码或与纳代码相关联的结构，这里称为可检测特征标签。

公开(公告)号：WO2014021862A1

公开(公告)日：2014-02-06

申请号：PCT/US2012/049031

申请日：2012-07-31

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  WANG, Shih-Yuan ,  GIBSON, Gary ,  LI, Zhiyong ,  BRATKOVSKI, Alexandre M. ,  BARCELO, Steven J. ,  KIM, Ansoon ,  YAMAKAWA, Mineo ,  ZHOU, Zhang-Lin ,  KUO, Huei Pei

Inventor： WANG, Shih-Yuan ,  GIBSON, Gary ,  LI, Zhiyong ,  BRATKOVSKI, Alexandre M. ,  BARCELO, Steven J. ,  KIM, Ansoon ,  YAMAKAWA, Mineo ,  ZHOU, Zhang-Lin ,  KUO, Huei Pei

IPC: G01N21/65 ,  G02B5/10

CPC classification number: G01N21/658 ,  A61F2/02 ,  A61F2/82 ,  G01N2201/068 ,  G02B5/10 ,  Y10T29/49826

Abstract: According to an example, an apparatus for performing spectroscopy includes a parabolic reflector and a plurality of surface-enhanced Raman spectroscopy (SERS) elements spaced from the parabolic reflector and positioned substantially at a focal point of the parabolic reflector. The parabolic reflector is to reflect Raman scattered light emitted from molecules in a near field generated by the plurality of SERS elements to substantially increase the flux of the Raman scattered light emitted out of the apparatus.

Abstract translation: 根据一个实例，用于执行光谱学的装置包括抛物面反射器和与抛物面反射器间隔开并且基本上位于抛物面反射器的焦点的多个表面增强拉曼光谱（SERS）元件。 抛物面反射器是反射由多个SERS元件产生的近场中的分子发射的拉曼散射光，以大大增加从该装置发出的拉曼散射光的通量。

公开(公告)号：WO2005066367A3

公开(公告)日：2007-03-01

申请号：PCT/US2004043364

申请日：2004-12-24

Applicant: INTEL CORP ,  SU XING ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO ,  BERLIN ANDREW ,  SUN LEI ,  ZHANG YUEGANG

Inventor： SU XING ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO ,  BERLIN ANDREW ,  SUN LEI ,  ZHANG YUEGANG

IPC: C01B31/02 ,  C12Q1/68 ,  D01F9/127 ,  H01L51/00 ,  H01L51/30

CPC classification number: B82Y40/00 ,  B82Y10/00 ,  B82Y30/00 ,  C01B32/162 ,  C01B2202/08 ,  C01B2202/36 ,  D01F9/127 ,  H01L51/0048 ,  H01L51/0052

Abstract: The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.

Abstract translation: 本文公开的方法，装置和系统涉及碳纳米管的有序阵列。 在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成，将聚合物（120,210）分子附着到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。 聚合物（120,210）分子对齐技术。 纳米管阵列可以附着到基板的选定区域（110,310）。 在所选择的区域（110,310）内，纳米管是非随机分布的。 本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。 在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

公开(公告)号：WO2005066366A3

公开(公告)日：2006-03-02

申请号：PCT/US2004043091

申请日：2004-12-24

Applicant: INTEL CORP ,  RAO VALLURI ,  NEUBAUER GABI ,  KIRCH STEVEN ,  YAMAKAWA MINEO ,  BERLIN ANDREW

Inventor： RAO VALLURI ,  NEUBAUER GABI ,  KIRCH STEVEN ,  YAMAKAWA MINEO ,  BERLIN ANDREW

IPC: C12Q1/68 ,  B01L3/00 ,  G01N21/05 ,  G01N21/65

CPC classification number: G01N21/05 ,  B01L3/5027 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0896 ,  B01L2400/0454 ,  B01L2400/0463 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/651 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/628

Abstract: The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction.

Abstract translation: 本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。 该方法涉及使用表面增强拉曼光谱（SERS）检测核苷酸，核苷或碱基。 检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。 合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。

公开(公告)号：WO2005066635A1

公开(公告)日：2005-07-21

申请号：PCT/US2004/043363

申请日：2004-12-24

Applicant: INTEL CORPORATION ,  RAO, Valluri ,  MA, Qing ,  YAMAKAWA, Mineo ,  BERLIN, Andrew ,  WANG, Li-Peng ,  ZHANG, Yuegang

Inventor： RAO, Valluri ,  MA, Qing ,  YAMAKAWA, Mineo ,  BERLIN, Andrew ,  WANG, Li-Peng ,  ZHANG, Yuegang

IPC: G01N33/543

CPC classification number: G01N33/54373 ,  B82Y15/00 ,  B82Y30/00 ,  G01N27/126 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2437 ,  G01N29/348 ,  G01N33/0031 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0426 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/25375

Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator’s frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator’s frequency response.

Abstract translation: 使用包含具有功能化表面以与靶生物分子反应的共振器的生物传感器来检测样品中存在生物分子的系统和方法。 在一个实施例中，器件包括压电谐振器，其具有被配置为与靶分子反应的官能化表面，从而改变谐振器的质量和/或电荷，从而改变谐振器的频率响应。 将曝光后的谐振器频率响应与参考值进行比较，例如在暴露于采样之前的频率响应，存储的基准频率响应或控制谐振器的频率响应。

公开(公告)号：WO2006023458A1

公开(公告)日：2006-03-02

申请号：PCT/US2005/029019

申请日：2005-08-13

Applicant: INTEL CORPORATION ,  SUNDARARAJAN, Narayan ,  SUN, Lei ,  SU, Xing ,  YAMAKAWA, Mineo ,  JINGWU, Zhang ,  CHAN, Selena ,  BERLIN, Andrew ,  KOO, Tae-Woong ,  ROTH, Mark ,  GAFEN, Phil

Inventor： SUNDARARAJAN, Narayan ,  SUN, Lei ,  SU, Xing ,  YAMAKAWA, Mineo ,  JINGWU, Zhang ,  CHAN, Selena ,  BERLIN, Andrew ,  KOO, Tae-Woong ,  ROTH, Mark ,  GAFEN, Phil

IPC: G01N33/68 ,  G01N21/65

CPC classification number: G01N33/6851 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  Y02A90/26

Abstract: Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diognosis, prognosis and drug efficacy studies, emzymatic activity profiling and assays.

Abstract translation: 本发明的实施例提供了用于使用表面增强拉曼（SERS）和拉曼光谱来检测，鉴定，区分和量化蛋白质和肽的修饰状态的装置和方法。 本发明实施方案的应用包括例如蛋白质组广泛的修饰分析和应用于疾病预后，预后和药物功效研究，酶活性分析和测定的分析。

公开(公告)号：WO2006069366A1

公开(公告)日：2006-06-29

申请号：PCT/US2005/046993

申请日：2005-12-21

Applicant: INTEL CORPORATION ,  YAMAKAWA, Mineo

Inventor： YAMAKAWA, Mineo

IPC: G01N33/68

CPC classification number: G01N33/6842 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/6803

Abstract: Methods for analyzing a protein are provided, including isolating the protein having original reactive functional groups from a biological sample, and converting substantially all original reactive functional groups into thiol groups, followed by attaching tags to the protein via the thiol groups.

Abstract translation: 提供了用于分析蛋白质的方法，包括从生物样品中分离具有原始反应性官能团的蛋白质，并将基本上所有的原始反应性官能团转化成硫醇基团，然后通过硫醇基团将标签附着到蛋白质上。

公开(公告)号：WO2006023458A9

公开(公告)日：2006-04-06

申请号：PCT/US2005029019

申请日：2005-08-13

Applicant: INTEL CORP ,  SUNDARARAJAN NARAYAN ,  SUN LEI ,  SU XING ,  YAMAKAWA MINEO ,  JINGWU ZHANG ,  CHAN SELENA ,  BERLIN ANDREW ,  KOO TAE-WOONG ,  ROTH MARK ,  GAFEN PHIL

Inventor： SUNDARARAJAN NARAYAN ,  SUN LEI ,  SU XING ,  YAMAKAWA MINEO ,  JINGWU ZHANG ,  CHAN SELENA ,  BERLIN ANDREW ,  KOO TAE-WOONG ,  ROTH MARK ,  GAFEN PHIL

IPC: G01N33/68 ,  G01N21/65

CPC classification number: G01N33/6851 ,  G01N21/658 ,  G01N33/54373 ,  G01N33/68 ,  G01N33/6842 ,  G01N33/6848 ,  Y02A90/26

Abstract: Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diognosis, prognosis and drug efficacy studies, emzymatic activity profiling and assays.

Abstract translation: 本发明的实施方案提供了使用表面增强拉曼（SERS）和拉曼光谱法检测，鉴定，区分和定量蛋白质和肽的修饰状态的装置和方法。 本发明的实施方案的应用包括例如蛋白质组广泛的修饰分析和分析，其应用于疾病预后，预后和药物功效研究，酶活性分析和测定。

公开(公告)号：WO2005066367A2

公开(公告)日：2005-07-21

申请号：PCT/US2004/043364

申请日：2004-12-24

Applicant: INTEL CORPORATION ,  SU, Xing ,  SUNDARARAJAN, Narayan ,  YAMAKAWA, Mineo ,  BERLIN, Andrew ,  SUN, Lei ,  ZHANG, Yuegang

Inventor： SU, Xing ,  SUNDARARAJAN, Narayan ,  YAMAKAWA, Mineo ,  BERLIN, Andrew ,  SUN, Lei ,  ZHANG, Yuegang

IPC: C12Q1/68

CPC classification number: B82Y40/00 ,  B82Y10/00 ,  B82Y30/00 ,  C01B32/162 ,  C01B2202/08 ,  C01B2202/36 ,  D01F9/127 ,  H01L51/0048 ,  H01L51/0052

Abstract: The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.

Abstract translation: 本文公开的方法，装置和系统涉及碳纳米管的有序阵列。 在本发明的具体实施方案中，通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成纳米管阵列，将聚合物（120,210）分子连接到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。 聚合物（120,210）分子对齐技术。 纳米管阵列可以附着到基板的选定区域（110,310）。 在所选择的区域（110,310）内，纳米管是非随机分布的。 本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列的装置以及包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统。 在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

公开(公告)号：WO2005066366A2

公开(公告)日：2005-07-21

申请号：PCT/US2004/043091

申请日：2004-12-24

Applicant: INTEL CORPORATION ,  RAO, Valluri ,  NEUBAUER, Gabi ,  KIRCH, Steven ,  YAMAKAWA, Mineo ,  BERLIN, Andrew

Inventor： RAO, Valluri ,  NEUBAUER, Gabi ,  KIRCH, Steven ,  YAMAKAWA, Mineo ,  BERLIN, Andrew

IPC: C12Q1/68

CPC classification number: G01N21/05 ,  B01L3/5027 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0896 ,  B01L2400/0454 ,  B01L2400/0463 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/651 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656 ,  C12Q2565/628

Abstract: The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction.

Abstract translation: 本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。 该方法涉及使用表面增强拉曼光谱（SERS）检测核苷酸，核苷或碱基。 检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。 合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。