公开(公告)号：WO2003087206A3

公开(公告)日：2003-10-23

申请号：PCT/US2002/024675

申请日：2002-08-01

Applicant: THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY ,  YAN, Mingdi ,  BARTLETT, Michele

Inventor： YAN, Mingdi ,  BARTLETT, Michele

IPC: G03F7/00 ,  G03F7/004

Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

公开(公告)号：WO2012071461A3

公开(公告)日：2012-05-31

申请号：PCT/US2011/061936

申请日：2011-11-22

Applicant: THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY ,  YAN, Mingdi ,  WANG, Xin ,  JAYAWARDENA, H.S.N.

Inventor： YAN, Mingdi ,  WANG, Xin ,  JAYAWARDENA, H.S.N.

IPC: G01N33/533 ,  G01N33/551 ,  G01N33/68 ,  C12Q1/68 ,  A61K47/48

Abstract: Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern using statistical analysis to produce score plots illustrating the level of differentiation and/or classification. Also disclosed are methods for making perhalophenylazide-derived nanoparticle probes, individually or by using a microarray technique. Particular embodiments concern methods for using the perhalophenylazide-derived nanoparticle probes to diagnose, detect, and/or treat a disease. Kits comprising the perhalophenylazide-derived nanoparticle probes are also disclosed.

公开(公告)号：WO2008156510A3

公开(公告)日：2009-04-23

申请号：PCT/US2008003348

申请日：2008-03-12

Applicant: STATE OF OREGON ACTING BY & TH ,  YAN MINGDI ,  RAMSTROEM OLOF ,  LIU LI-HONG

Inventor： YAN MINGDI ,  RAMSTROEM OLOF ,  LIU LI-HONG

IPC: G01N33/53

CPC classification number: G01N33/5434 ,  C01P2002/82 ,  C01P2002/86 ,  C01P2004/04 ,  C08J7/047 ,  C08J7/065 ,  C08J7/12 ,  C08J7/16 ,  C09C1/24 ,  C09C1/3072 ,  C09C1/42 ,  C09C1/46 ,  G01N33/54346

Abstract: Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, devices surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide.

Abstract translation: 公开了包括功能化材料的装置以及用于制造和使用这些装置的方法的实施例。 示例性装置包括眼科装置，纳米颗粒，石英晶体微量平衡，微阵列和纳米复合材料。 在具体实施方案中，装置表面用单体和/或聚合物（通常为碳水化合物单体和/或聚合物）进行改性。 公开了制造和使用这种装置的方法的实施例。 使用官能化的全卤代叠氮基，单体和/或聚合物共价键合到表面上。 在一些实施方案中，装置表面用全卤代苯偶酰胺官能化。 随后使用全卤代苯偶酰共价键将一种或多种单体和/或聚合物共价结合到装置表面。 在其它实施方案中，单体和/或聚合物用官能化的全卤代叠氮化物衍生化。 然后，衍生化的单体和/或聚合物使用全卤代苯偶酰共价键合到器件表面。

公开(公告)号：WO2012071461A2

公开(公告)日：2012-05-31

申请号：PCT/US2011061936

申请日：2011-11-22

Applicant: OREGON STATE ,  YAN MINGDI ,  WANG XIN ,  JAYAWARDENA H S N

Inventor： YAN MINGDI ,  WANG XIN ,  JAYAWARDENA H S N

IPC: G01N33/533 ,  A61K47/48 ,  C12Q1/68 ,  G01N33/551 ,  G01N33/68

CPC classification number: G01N33/587 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0065 ,  A61K49/0093 ,  G01N2400/00 ,  Y10T436/143333

Abstract: Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern using statistical analysis to produce score plots illustrating the level of differentiation and/or classification. Also disclosed are methods for making perhalophenylazide-derived nanoparticle probes, individually or by using a microarray technique. Particular embodiments concern methods for using the perhalophenylazide-derived nanoparticle probes to diagnose, detect, and/or treat a disease. Kits comprising the perhalophenylazide-derived nanoparticle probes are also disclosed.

Abstract translation: 所公开的实施方案涉及使用全卤代苯酰叠氮衍生的纳米粒子探针或多种这样的探针来区分和分类一个或多个靶标。 具体实施方式涉及使用统计分析来产生说明分化和/或分类水平的分数图。 还公开了单独地或通过使用微阵列技术来制备来自perhalophenylazide的纳米粒子探针的方法。 具体实施方式涉及使用来自过氯化苯酰基化物的纳米粒子探针来诊断，检测和/或治疗疾病的方法。 还公开了包含来自perhalophenylazide的纳米粒子探针的试剂盒。

公开(公告)号：WO2003087206A2

公开(公告)日：2003-10-23

申请号：PCT/US2002/024675

申请日：2002-08-01

Applicant: THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY ,  YAN, Mingdi ,  BARTLETT, Michele

Inventor： YAN, Mingdi ,  BARTLETT, Michele

IPC: C08K

CPC classification number: C40B60/14 ,  B01J2219/00432 ,  B01J2219/00443 ,  B01J2219/00531 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B40/10 ,  G03F7/0035 ,  G03F7/008 ,  G03F7/012 ,  G03F7/11

Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

Abstract translation: 公开了将聚合物材料直接或通过连接分子粘附到基底上的方法。 可以使用这些方法容易地形成结构，例如微结构，包括微孔和微孔阵列。 在一些实施方案中，提供了由聚合材料完全形成的微结构，使得可以调整微结构的化学和物理性能。 例如，提供具有包含极性聚合物材料的底部的微孔和包含非极性聚合物材料的阱侧/顶部。 生物化学试剂可以很容易地传递到这种“智能井”，因为井底对于试剂的内在吸引力和阱侧/顶部之间的固有排斥结合起来将试剂引导到井。

公开(公告)号：WO2008156510A2

公开(公告)日：2008-12-24

申请号：PCT/US2008/003348

申请日：2008-03-12

Applicant: STATE OF OREGON ACTING BY & THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY ,  YAN, Mingdi ,  RAMSTRÖM, Olof ,  LIU, Li-Hong

Inventor： YAN, Mingdi ,  RAMSTRÖM, Olof ,  LIU, Li-Hong

IPC: G01N33/53

CPC classification number: G01N33/5434 ,  C01P2002/82 ,  C01P2002/86 ,  C01P2004/04 ,  C08J7/047 ,  C08J7/065 ,  C08J7/12 ,  C08J7/16 ,  C09C1/24 ,  C09C1/3072 ,  C09C1/42 ,  C09C1/46 ,  G01N33/54346

Abstract: Devices comprising functionalized materials, and embodiments of a method for making and using such devices, are disclosed. Exemplary devices include ophthalmic devices, nanoparticles, quartz crystal microbalances, microarrays, and nanocomposites. In particular embodiments, device surfaces are modified with monomers and/or polymers, typically carbohydrate monomers and/or polymers. Embodiments of a method for making and using such devices are disclosed. Monomers and/or polymers are covalently bonded to surfaces using functionalized perhalophenylazides. In some embodiments, devices surfaces are functionalized with a perhalophenylazide. One or more monomers and/or polymers subsequently are covalently bonded to the device surface using the perhalophenylazide. In other embodiments, monomers and/or polymers are derivatized with a functionalized perhalophenylazide. The derivatized monomers and/or polymers then are covalently bonded to the device surface using the perhalophenylazide.

Abstract translation: 公开了包括功能化材料的装置以及用于制造和使用这些装置的方法的实施例。 示例性装置包括眼科装置，纳米颗粒，石英晶体微量平衡，微阵列和纳米复合材料。 在具体实施方案中，装置表面用单体和/或聚合物（通常为碳水化合物单体和/或聚合物）进行改性。 公开了制造和使用这种装置的方法的实施例。 使用官能化的全卤代叠氮基，单体和/或聚合物共价键合到表面上。 在一些实施方案中，装置表面用全卤代苯偶酰胺官能化。 随后使用全卤代苯偶酰共价键将一种或多种单体和/或聚合物共价键合到器件表面。 在其它实施方案中，单体和/或聚合物用官能化的全卤代叠氮化物衍生化。 然后，衍生化的单体和/或聚合物使用全卤代苯偶酰共价键合到器件表面。

公开(公告)号：WO03087206A8

公开(公告)日：2005-03-17

申请号：PCT/US0224675

申请日：2002-08-01

Applicant: OREGON STATE ,  YAN MINGDI ,  BARTLETT MICHELE

Inventor： YAN MINGDI ,  BARTLETT MICHELE

IPC: B01J20/285 ,  B01J20/281 ,  B01J20/283 ,  C08K20060101 ,  C08K3/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N30/88 ,  H01L21/31 ,  C08K

CPC classification number: C40B60/14 ,  B01J2219/00432 ,  B01J2219/00443 ,  B01J2219/00531 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B40/10 ,  G03F7/0035 ,  G03F7/008 ,  G03F7/012 ,  G03F7/11

Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such "smart wells" because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

Abstract translation: 公开了将聚合物材料直接或通过连接分子粘附到基底上的方法。 可以使用这些方法容易地形成结构，例如微结构，包括微孔和微孔阵列。 在一些实施方案中，提供了由聚合材料完全形成的微结构，使得可以调整微结构的化学和物理性能。 例如，提供具有包含极性聚合物材料的底部的微孔和包含非极性聚合物材料的阱侧/顶部。 生物化学试剂可以很容易地传递到这种“智能井”，因为井底对于试剂的内在吸引力和阱侧/顶部之间的固有排斥结合起来将试剂引导到井。