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公开(公告)号：JP6038653B2
公开(公告)日：2016-12-07
申请号：JP2012525530
申请日：2010-08-19
Inventor： クリンガー、エティー
CPC classification number: A61K31/785 , A61K38/02 , A61K38/07 , A61K38/16 , A61K9/0019
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2.发明专利Copolymer 1 related polypeptide for use as molecular weight marker and for therapeutic use 有权共聚物1用作分子量标记和治疗用途的相关多肽
公开(公告)号：JP2010271325A
公开(公告)日：2010-12-02
申请号：JP2010142689
申请日：2010-06-23
Applicant: Yeda Research & Development Co Ltd , イエダ リサーチ アンド デベロップメント カンパニー リミテッドYeda Research And Development Company Limited
Inventor： GAD ALEXANDER , LIS DORA
IPC: G01N30/04 , G01N30/88 , A61K38/00 , A61K38/16 , A61K38/21 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/06 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P27/02 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K14/00 , G01N33/68
CPC classification number: G01N33/68 , A61K38/02 , C07K14/001
Abstract: PROBLEM TO BE SOLVED: To provide a molecular weight marker for accurately determining the molecular weight of glatiramer acetate and other copolymers. SOLUTION: The invention relates to a method for determining whether a mixture of polypeptides, each of which includes alanine, glutamic acid, tyrosine and lysine, has an average molecular weight of 2,000-40,000 daltons. In the mixture, the molar fraction of alanine is 0.38-0.5, of glutamic acid is 0.13 to 0.15, of tyrosine is 0.08 to 0.10, and of lysine is 0.3 to 0.4. In order to determine the average molecular weight of the mixture, provision of the mixture to a calibrated chromatography device is included, wherein the chromatography device is calibrated by subjecting a polypeptide to chromatography with the chromatography device to establish a linear relationship between retention time in a column and the logarithm of the molecular weight. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供用于精确测定醋酸格拉默和其它共聚物的分子量的分子量标记。 解决方案：本发明涉及一种用于确定每种包括丙氨酸，谷氨酸，酪氨酸和赖氨酸的多肽的混合物的平均分子量为2,000-40,000道尔顿的方法。 在混合物中，丙氨酸的摩尔分数为0.38-0.5，谷氨酸的摩尔分数为0.13至0.15，酪氨酸的摩尔分数为0.08至0.10，赖氨酸为0.3至0.4。 为了确定混合物的平均分子量，包括将混合物提供到经校准的色谱装置，其中色谱装置通过使多肽与色谱装置进行色谱校准，以建立在保留时间之间的线性关系 柱和分子量的对数。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP6169644B2
公开(公告)日：2017-07-26
申请号：JP2015098415
申请日：2015-05-13
Inventor： エティー・クリンガー
CPC classification number: A61K9/0019 , A61K31/19 , A61K31/785 , A61K38/02 , A61K38/07 , A61K38/16
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公开(公告)号：JP4800481B2
公开(公告)日：2011-10-26
申请号：JP2000561206
申请日：1999-07-23
Applicant: イエダ リサーチ アンド デベロップメント カンパニー リミテッドYeda Research And Development Company Limited , プレジデント アンド フェローズ オブ ハーヴァード カレッジ
Inventor： アーノン、ルース , アハロニ、リナ , ストロミンガー、ジャック・エル , セラ、マイケル , テイテルバウム、ドボラ , フリドキス−ハレリ、マーシャ
IPC: A61K38/00 , A61K45/00 , A61K38/02 , A61K38/06 , A61K38/07 , A61K38/21 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P37/00 , C07K20060101 , C07K5/11 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00
CPC classification number: G01N33/6842
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公开(公告)号：JP4744763B2
公开(公告)日：2011-08-10
申请号：JP2001561349
申请日：2001-02-20
Applicant: イエダ リサーチ アンド デベロップメント カンパニー リミテッドYeda Research And Development Company Limited , メルク セロノ ソシエテ アノニム
Inventor： キム、ソーヒュン , チバツコ、ヨランデ , ディナレロ、チャールズ , ノビック、ダニエラ , デーフェンテル、サンタール ファン , プラテル−チベルク、クリスティーネ , ルビンステイン、メナケム
IPC: A61K38/00 , C12N15/09 , A61K31/00 , A61K35/12 , A61K38/17 , A61K38/21 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/16 , A61P19/02 , A61P19/08 , A61P25/32 , A61P29/00 , A61P31/12 , A61P37/00 , A61P37/02 , A61P43/00 , C07K16/24 , C12N15/63
CPC classification number: C07K16/244 , A61K38/00 , A61K39/395 , A61K48/00 , A61K2039/505 , A61K2300/00
Abstract: The invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of liver injury. The invention further relates to the use of IL-18 inhibitors in the preparation of a medicament for treatment and/or prevention of arthritis, in particular rheumatoid arthritis. In addition to this, the invention relates to the use of inhibitors of IL-18 in the preparation of a medicament for treatment and/or prevention of inflammatory bowel diseases, in particular of Crohn's disease and ulcerative colitis.
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Patent Agency Ranking6.发明专利
公开(公告)号：JP4629229B2
公开(公告)日：2011-02-09
申请号：JP2000572252
申请日：1999-09-24
Inventor： ガッド、アレクサンダー , リス、ドラ
IPC: C07K14/00 , G01N30/04 , A61K38/00 , A61K38/16 , A61K38/21 , A61K39/395 , A61K45/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , A61P37/02 , G01N30/88 , G01N33/68
CPC classification number: G01N33/68 , A61K38/02 , C07K14/001
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公开(公告)号：JP2007097593A
公开(公告)日：2007-04-19
申请号：JP2006305759
申请日：2006-11-10
Applicant: Yeda Research & Development Co Ltd , イエダ リサーチ アンド デベロップメント カンパニー リミテッドYeda Research And Development Company Limited
Inventor： REVEL MICHEL , ABRAMOVICH CAROLINA , RATOVITSKI EDWARD
IPC: C12N15/09 , A61K35/12 , A61K38/00 , A61K49/00 , A61P1/16 , A61P25/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P43/00 , C07H21/04 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/715 , C07K16/00 , C07K19/00 , C12N15/12 , C12P21/02 , G01N33/53 , G01N33/68
CPC classification number: C07K14/715 , A61K38/00 , C07K2319/00 , G01N33/6866
Abstract: PROBLEM TO BE SOLVED: To provide a soluble interferon α-receptor 1 type and 2 type obtained from a naturally occurring mRNA and to provide a DNA molecule encoding the same. SOLUTION: An isolated DNA molecule encodes a mammalian soluble and non-membranal form interferon α-receptor. The receptor or an analog thereof is provided. A method for preparing the same, a composition and a drug comprising the same are provided. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 待解决的问题：提供从天然存在的mRNA获得的可溶性干扰素α受体1型和2型，并提供编码它们的DNA分子。 解决方案：分离的DNA分子编码哺乳动物可溶性和非膜形式的干扰素α受体。 提供受体或其类似物。 提供其制备方法，组合物和包含其的药物。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP3907661B2
公开(公告)日：2007-04-18
申请号：JP2005004934
申请日：2005-01-12
Inventor： ノビック ダニエラ , ルビンシュタイン メナケム
IPC: A61K38/00 , A61P3/10 , A61P29/00 , A61P31/18 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07K1/14 , C07K1/16 , C07K1/22 , C07K14/47 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/715 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/20 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08
CPC classification number: C07K16/00 , A61K38/00 , C07K14/715 , C07K16/2866 , C07K2319/75
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9.发明专利INTERFERON-α/β BINDING PROTEIN, METHOD FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME 有权INTERFERON-α/β结合蛋白，其生产方法和含有该蛋白质的药物组合物
公开(公告)号：JP2005162762A
公开(公告)日：2005-06-23
申请号：JP2005004934
申请日：2005-01-12
Applicant: Yeda Research & Development Co Ltd , イエダ リサーチ アンド デベロップメント カンパニー リミテッドYeda Research And Development Company Limited
Inventor： RUBINSTEIN MENACHEM , NOVICK DANIELA
IPC: A61K38/00 , A61P3/10 , A61P29/00 , A61P31/18 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07K1/14 , C07K1/16 , C07K1/22 , C07K14/47 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/715 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N5/20 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08
CPC classification number: C07K16/00 , A61K38/00 , C07K14/715 , C07K16/2866 , C07K2319/75
Abstract: PROBLEM TO BE SOLVED: To obtain an interferon-α/β binding protein, its mutein and fused protein thereof, their salts, functional derivatives and active fractions, to provide a method for producing the protein, and to provide DNA molecule encoding the protein, an expression medium containing the DNA molecule, a host cell transformed by the medium, a recombinants of the protein and a medicinal composition containing the protein.
SOLUTION: The new soluble IFN-α/β binding protein, a method for producing the same and the medicinal composition containing the protein are provided, The protein is useful for prevention and treatment and diagnosis of diseases accompanied with an existing state of an excess amount of IFN-α or IFN-β.
COPYRIGHT: (C)2005,JPO&NCIPIAbstract translation: 待解决的问题：为了获得干扰素-α/β结合蛋白，其突变蛋白及其融合蛋白，其盐，功能衍生物和活性成分，以提供蛋白质的制备方法，并提供编码DNA的DNA分子 蛋白质，含有DNA分子的表达培养基，由培养基转化的宿主细胞，蛋白质的重组体和含有蛋白质的药物组合物。 解决方案：提供新的可溶性IFN-α/β结合蛋白，其制备方法和含有该蛋白质的药用组合物，该蛋白质可用于预防和治疗伴有现有状态的疾病 过量的IFN-α或IFN-β。 版权所有（C）2005，JPO＆NCIPI
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10.发明专利
公开(公告)号：JP2005200422A
公开(公告)日：2005-07-28
申请号：JP2005033495
申请日：2005-02-09
Applicant: Yeda Research & Development Co Ltd , イエダ リサーチ アンド デベロップメント カンパニー リミテッドYeda Research And Development Company Limited
Inventor： COHEN BATYA , NOVICK DANIELA , RUBINSTEIN MENACHEM
IPC: G01N33/53 , A61K38/00 , A61K38/17 , A61K38/21 , A61K39/395 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/52 , C07K14/555 , C07K14/715 , C07K16/00 , C07K16/24 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/62 , C12N15/63 , C12P21/00 , C12P21/02 , C12R1/91 , G01N33/577
CPC classification number: C07K14/715 , A61K38/00 , C07K16/2866 , C07K2319/00
Abstract: PROBLEM TO BE SOLVED: To provide an interferon alpha/beta binding protein, a DNA molecule encoding the same, and a method for producing the protein, and a pharmaceutical composition containing them, antibodies against them, a replicable expression vehicle capable of expressing them and to provide a host cell transformed by the vehicle. SOLUTION: This invention relates to the IFN α/β binding protein selected from IFNAB-BPI, IFNAB-BPII, precursors thereof, fusion protein or mucin form of IFNAB-BP I and IFNAB-BP II, functional derivative thereof or active fraction thereof, or salts of the binding protein, and the DNA molecule encoding thereof and the method for producing thereof and pharmaceutical composition containing thereof and antibodies against the proteins, the replicable expression vehicle expressing thereof and to provide the host cell transformed by the vehicle. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 待解决的问题：为了提供干扰素α/β结合蛋白，编码该干扰素α/β结合蛋白的DNA分子及其制备方法，含有它们的药物组合物，抗体的抗体，能够 表达它们并提供由车辆转化的宿主细胞。 本发明涉及选自IFNAB-BPI，IFNAB-BPII，其前体，IFNAB-BP I和IFNAB-BP II的融合蛋白或粘蛋白形式的IFNα/β结合蛋白，其功能衍生物或活性 其结合蛋白的分数，结合蛋白的盐和其编码的DNA分子及其制备方法和含有它们的药物组合物和针对蛋白质的抗体，表达载体的可复制表达载体，并提供由载体转化的宿主细胞。 版权所有（C）2005，JPO＆NCIPI
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