公开(公告)号：WO1996022272A1

公开(公告)日：1996-07-25

申请号：PCT/EP1996000012

申请日：1996-01-04

Applicant: BASF AKTIENGESELLSCHAFT ,  MERKLE, Hans, Rupert ,  FRETSCHNER, Erich ,  HANSEN, Hanspeter ,  ZIPPERER, Bernhard

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C07C53/19

CPC classification number: C07B57/00 ,  C07C51/09 ,  C07C53/19

Abstract: The present invention relates to a process for producing optically active 2-halogen propionic acids in which the corresponding optically active 2-halogen propionic acid alkyl ester is reacted at high temperature with a carboxylic acid in a transacylation reaction to form the optically active 2-halogen propionic acid and the carboxylic acid alkyl ester and the optically active 2-halogen propionic acid is separated from the reaction mixture. The optically active products of the process are important intermediate products for the production of plant protection agents and pharmaceuticals.

Abstract translation: 本发明涉及一种制备光学活性的2-卤代酸，该方法包括使相应的光学活性烷基在升高的温度2-卤代丙酸酯与羧酸在Umacylierungsreaktion反应以形成所述光学活性的2-卤代丙酸和烷基羧酸盐，和光学所获得的 活性2-卤代丙酸是从反应混合物中分离出来。 该方法的光学活性产物是用于生产农药和药物的重要中间体。

公开(公告)号：WO1995006130A1

公开(公告)日：1995-03-02

申请号：PCT/EP1994002738

申请日：1994-08-17

Applicant: BASF AKTIENGESELLSCHAFT ,  LADNER, Wolfgang ,  RETTENMAIER, Hansjörg ,  ZIPPERER, Bernhard ,  HANSEN, Hanspeter

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C12P07/40

CPC classification number: C12P41/005 ,  C07C51/09 ,  C12P7/40 ,  C07C53/19

Abstract: A process is disclosed for preparing (L)-2-chlorpropionic acid and its alkali, alkaline earth metal or ammonium salts. For that purpose, L-chlorpropionic acid isobutyl ester is hydrolysed at a pH value from 4 to 8 in the presence of a lipase from pseudomonas spec. DSM 8246 and the optically active reaction product is isolated from the reaction mixture or further reacted in situ in a per se known manner either directly or after conversion of the salt into the acid. The optically active products obtained by this process constitute important intermediate products for preparing plant protective agents.

Abstract translation: 一种用于制备（L）-2-氯丙酸和它的碱金属，碱土金属或铵盐通过L-氯丙在来自假单胞菌规格的脂肪酶的存在下的4至8的pH值进行反应的过程。 DSM 8246被水解和光学活性反应产物分离，或者直接或者转换该盐的成以通常的方式在本身从反应混合物中的酸后或进一步原位反应。 该方法的光学活性的产品是用于作物保护剂的制备中重要的中间体。

公开(公告)号：CA2032285A1

公开(公告)日：1991-06-17

申请号：CA2032285

申请日：1990-12-14

Applicant: SEELE RAINER ,  ZIPPERER BERNHARD ,  KEIL MICHAEL ,  GOETZ NORBERT ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  KOBER REINER ,  KUEKENHOEHNER THOMAS ,  HARREUS ALBRECHT ,  RADEMACHER WILHELM

Inventor： SEELE RAINER ,  ZIPPERER BERNHARD ,  KEIL MICHAEL ,  GOETZ NORBERT ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  KOBER REINER ,  KUEKENHOEHNER THOMAS ,  HARREUS ALBRECHT ,  RADEMACHER WILHELM

IPC: A01N43/50 ,  A01N43/653 ,  C07D233/58 ,  C07D233/60 ,  C07D249/08 ,  C07D303/04 ,  C07D303/08 ,  C07D303/20 ,  C07D303/22 ,  C07D303/34 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/08 ,  C07D403/12 ,  C07D405/06 ,  C07D405/08 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/06 ,  C07D409/08 ,  C07D409/12 ,  C07D409/14 ,  C07D493/10 ,  C07D495/10 ,  C07D521/00 ,  C07D405/00 ,  C07D409/00 ,  C07D233/56

Abstract: O.Z. 0050/41291 Azolylmethylcycloalkanols of the general formula I (I) where R1 and R5 are identical or different and are each hydrogen or alkyl; R1 and R5 together are >CH=CH-R7 or >CH-Z-R7, where Z is CH2, O, S, SO, SO2 or N-R8; R7 is alkyl, phenyl, biphenyl, naphthyl, heteroaryl, benzyl or cycloalkyl, where each of these radicals may be substituted, or is tetrahydropyranyl; R2 and R3 are each hydrogen or alkyl, or, where R1 and R5 are >CH=CH-R7, R2 and R3 together may additionally be =CH-R7; R4 and R6 are each hydrogen or alkyl, or R3 and R4 together with the carbon atoms on which they are substituents are a saturated or unsaturated 5-membered or 6-membered carbocyclic ring, or R2, R3, R4 and R9 together with the carbon atoms on which they are substituents are an unsubstituted or halogensubstituted phenyl ring, or where R1 and R5 are >C=CH-R7, R2 and R3 together may additionally be =CH-R7; R8 and R9 to R12 are each hydrogen, alkyl, phenyl, biphenyl, naphthyl, heteroaryl, benzyl, dioxolanyl or cycloalkyl, where each of these radicals may be substituted; T is (CH2)n, =CR11R12, O or S; n is an integer from 1 to 5, with the proviso that R1 to O.Z. 0050/41291 R12 are not simultaneously hydrogen, and with the proviso that R1 and R5 together are not or when R2 to R4 and R6 to R12 are hydrogen, and X is CH or N, and plant-tolerated acid salts and metal complexes thereof, and growth regulators and fungicides containing these compounds.

公开(公告)号：CA2013268A1

公开(公告)日：1990-11-05

申请号：CA2013268

申请日：1990-03-29

Applicant: ZIPPERER BERNHARD ,  SAUTER HUBERT ,  AMMERMANN EBERHARD ,  LORENZ GISELA

Inventor： ZIPPERER BERNHARD ,  SAUTER HUBERT ,  AMMERMANN EBERHARD ,  LORENZ GISELA

IPC: A01N43/10 ,  A01N43/40 ,  C07D213/30 ,  C07D213/89 ,  C07D405/06 ,  C07D409/06 ,  C07D213/24

Abstract: Pyridines of the formula 1, where R1 is hydrogen, C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl or an acyl radical COR2; R2 is C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, C1-C6 haloalkyl or substituted or unsubstituted aryl; A is one of the groups , or ; where R3 and R4 are identical or differ and each is C1-C6-alkyl, with the proviso that R3 and R4 are not simultaneously methyl; R5 is one of the groups (CH2)n, CH2OCH2, CH25(O)mCH2, CH2CH2O or CH2CH2 S(O)m, n denoting 1, 2, 3, 4 or 5, and m being 0, 1 or 2; Ar is aryl which is unsubstituted or bears from one to five substituents selected from the group consisting of C1-C6-alkyl, phenyl, halogen, C1-C6-haloalkyl, C1C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkoxyiminocarbyl, phenoxy, halophenoxy and benzyloxy, and the N-oxides and plant-tolerated acid addition salts thereof, and fungicides containing these compounds.

公开(公告)号：CA1312868C

公开(公告)日：1993-01-19

申请号：CA586577

申请日：1988-12-21

Applicant: ZIPPERER BERNHARD

Inventor： ZIPPERER BERNHARD ,  BUSCHMANN ERNST ,  LAUER MANFRED ,  AMMERMANN EBERHARD ,  LORENZ GISELA

IPC: A01N43/40 ,  C07D213/89

Abstract: O.Z. 0050/39665 Substituted pyridine-N-oxides of the formula (I), where R1 is alkyl and R2 is phenyl or substituted phenyl, salts thereof which are physiologically tolerated by plants, and fungicides containing them.

公开(公告)号：CA2033252A1

公开(公告)日：1991-06-30

申请号：CA2033252

申请日：1990-12-27

Applicant: ZIERKE THOMAS ,  ZIPPERER BERNHARD ,  SAUTER HUBERT ,  AMMERMANN EBERHARD ,  LORENZ GISELA

Inventor： ZIERKE THOMAS ,  ZIPPERER BERNHARD ,  SAUTER HUBERT ,  AMMERMANN EBERHARD ,  LORENZ GISELA

IPC: A01N43/40 ,  C07D213/30 ,  C07D213/50 ,  C07D405/04 ,  C07D409/14 ,  C07D413/14 ,  C07D213/55 ,  A01N43/80

Abstract: O.Z. 0050/41332 3-substituted pyridines I I (X = OH; Y = -O-CHO, -O-CO-W3R3, -O-SO2-W3R3 or X+Y = -O-CH(W3R3)-O-, 3O3CH(O3W4R4)-O-, -O-C(W3R3)(O-W4R4)-O-; W1-W4 = direct bond, -CH2-, -CH2-CH2, -CH(CH3)-, -CH2O-, -CH2S-; R1-R4 = unsubstituted or cycloalkylsubstituted C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl which is unsubstituted or substituted by 1-3 alkyl radicals, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, substituted or unsubstituted phenyl or naphthyl, substituted or unsubstituted 5-/6-membered heteroaryl with 1 to 3 heteroatoms; R2 is additionally H when X+Y= -O-CH(W3R3)-O-, -O-CH(O-W4R4)-O- or -O-C(W3R3)(O-W4R4)-O- and W2 = direct bond, except cis-1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)-1,2-epoxypropane, trans-1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)-1,2-epoxypropane, 1-(2,4-dichlorophenyl)-2-(pyrid-3-yl)-1,2-epoxybutane and 2,4-dichloro-.alpha.-¢1-hydroxy-1-(pyrid-3-yl)-ethyl!-benzyl methanesulfonate, and the N-oxides and the plant-tolerated mineral acid salts and metal complexes of I. The compounds I are suitable as fungicides.

公开(公告)号：CA2026385A1

公开(公告)日：1991-03-29

申请号：CA2026385

申请日：1990-09-27

Applicant: SEELE RAINER ,  ROHR WOLFGANG ,  ZIPPERER BERNHARD ,  KARBACH STEFAN ,  RUEB LOTHAR ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  RADEMACHER WILHELM ,  JUNG JOHANN

Inventor： SEELE RAINER ,  ROHR WOLFGANG ,  ZIPPERER BERNHARD ,  KARBACH STEFAN ,  RUEB LOTHAR ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  RADEMACHER WILHELM ,  JUNG JOHANN

IPC: A01N43/50 ,  A01N43/653 ,  C07D233/56 ,  C07D233/60 ,  C07D249/08 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D521/00

Abstract: O.Z. 0050/41136 Vinylazoles of the general formula I I, where A and B are alkyl, cycloalkyl, tetrahydropyranyl, pyridyl, naphthyl, biphenyl or phenyl, these radicals being substituted or unsubstituted, X is CH or N, and plant-tolerated acid addition salts and metal complexes thereof, and crop protection agents containing these compounds.

公开(公告)号：CA1296729C

公开(公告)日：1992-03-03

申请号：CA552126

申请日：1987-11-18

Applicant: ZIPPERER BERNHARD

Inventor： ZIPPERER BERNHARD ,  BUSCHMANN ERNST ,  GOETZ NORBERT ,  SCHIRMER ULRICH ,  AMMERMANN EBERHARD ,  POMMER ERNST-HEINRICH

IPC: A01N33/10 ,  A01N33/04 ,  A01N33/08 ,  A01N43/40 ,  A01N43/84 ,  C07C67/00 ,  C07C205/06 ,  C07C209/00 ,  C07C211/34 ,  C07C211/35 ,  C07C215/04 ,  C07C313/00 ,  C07C323/25 ,  C07C323/26 ,  C07C323/27 ,  C07C323/30 ,  C07C323/31 ,  C07C323/32 ,  C07D203/08 ,  C07D211/12 ,  C07D211/14 ,  C07D211/26 ,  C07D265/30 ,  C07D295/02 ,  C07D295/03 ,  C07D295/033 ,  C07D295/06 ,  C07D295/096 ,  C07D295/00

Abstract: Cyclohexylamines of the formula where X is a single bond or an alkylene chain, Y is hydrogen or an aryl, cyclohexyl, 4-cyclohexylcyclohexyl, perhydro-1- or 2-naphthyl or piperidyl radical, R1 and R2 are hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, cycloalkyl, cycloalkenyl or arylalkyl, or R1 and R2 together form an alkylene group and, together with the N atom, form a ring, and acid addition salts thereof, with the exception of compounds in which X is a single bond, Y is cyclohexyl, R1 and R2 are hydrogen or methyl, and the compounds in which X is C6-, C7- and C8-alkyl, Y is hydrogen and R1 and R2 together with the N atom whose substituents they are form a 2,6--dimethyl-morpholine radical, and fungicides containing such cyclohexylamines.

公开(公告)号：CA2035978A1

公开(公告)日：1991-08-10

申请号：CA2035978

申请日：1991-02-08

Applicant: ZIPPERER BERNHARD ,  LAUER MANFRED ,  GOETZ NORBERT ,  ZIERKE THOMAS ,  AMMERMANN EBERHARD ,  LORENZ GISELA

Inventor： ZIPPERER BERNHARD ,  LAUER MANFRED ,  GOETZ NORBERT ,  ZIERKE THOMAS ,  AMMERMANN EBERHARD ,  LORENZ GISELA

IPC: A01N43/40 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  C07D213/30 ,  C07D213/50 ,  C07D401/06 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07D213/04 ,  A01N43/48 ,  C07D213/89

Abstract: Hetarylalkenes of the general formula I I where Ar is hetaryl, A is C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C3-alkyl or unsubstituted or monosubstituted, disubstituted or trisubstituted aryl or aralkyl, Z is , , , or where R is hydrogen, C2-C4-acyl, unsubstituted or substituted benzoyl, C1-C4-alkylsulfonyl, unsubstituted or C1-C4-alkyl-substituted phenylsulfonyl or a radical R1, R1 is C1-C4-alkyl or unsubstituted or substituted phenyl or benzyl and Hal is fluorine, chlorine, bromine or iodine, and B is unsubstituted or substituted mononuclear or dinuclear aryl, aralkyl or hetaryl, and their N-oxides and addition salts, the preparation of these substances, intermediates for this purpose and the preparation thereof, fungicides containing hetarylalkenes and a corresponding method for controlling harmful fungi.

公开(公告)号：CA2024404A1

公开(公告)日：1991-03-10

申请号：CA2024404

申请日：1990-08-31

Applicant: SEELE RAINER ,  GOETZ NORBERT ,  KOBER REINER ,  ZIPPERER BERNHARD ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  GEBHARDT JOACHIM

Inventor： SEELE RAINER ,  GOETZ NORBERT ,  KOBER REINER ,  ZIPPERER BERNHARD ,  AMMERMANN EBERHARD ,  LORENZ GISELA ,  GEBHARDT JOACHIM

IPC: C07D303/08 ,  A01N43/50 ,  A01N43/653 ,  C07D213/48 ,  C07D249/08 ,  C07D303/12 ,  C07D303/16 ,  C07D303/34 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00 ,  A01N43/00

Abstract: O.Z. 0050/41099 Azolylmethyloxiranes I (A, B = 5-/6-membered hetaryl, alkyl, cycloalkyl, tetrahydropyranyl, tetrahydrothiopyranyl, phenyl, biphenyl, naphthyl or benzyl, the substituents A and B being unsubstituted or bearing up to three further radicals, with the proviso that at least one of the substituents A and B is hetaryl unless B is o-methylphenyl; Z = CH, N) and their acid addition salts and metal complexes, with the exception of 2-(imidazol-1-ylmethyl)-2-(4-fluorophenyl)-3-(pyrid-3-yl)-oxirane. The compounds I are suitable as fungicides.