Abstract:
본 발명은 조혈모세포 또는 전구 세포의 체외 확대 성장을 위한 스캐폴드 어셈블리, 상기 스캐폴드 어셈블리를 이용하는 조혈모세포 또는 전구 세포의 체외 확대 성장을 위한 관류형 생물 반응기 및 생물 반응 시스템에 관한 것이다. 본 발명의 스캐폴드 어셈블리 및 이를 이용한 관류형 반응기는 생체 친화성(biocompatibility), 화학적 적합성(chemicalcompatibility) 및 기계적 적합성(mechanical compatibility)을 가지는 재료를 사용하고, 쾌속 조형법에 의하여 세포 성장을 위한 3차원적 환경을 제공하는 스캐폴드와, 나노 시트로 구성됨으로써 구조적으로 골모세포성 니치(osteoblastic niche)와 유사할 뿐만 아니라, 상기 스캐폴드에 고정된 세포가 유실되지 않으면서 펌프에 의하여 일정 크기의 타진이 가능하여 상기 스캐폴드에 고정된 세포가 일정한 자극에 노출되어 조혈모세포 또는 전구 세포의 체외 성장을 위한 생체내와 유사한 최적의 환경을 제공하는 효과가 있다.
Abstract:
PURPOSE: A multi-layered molding device and a method for manufacturing biomaterials having microstructure are provided to uniformly and rapidly mass-produce microstructure biomaterials to not only a globular form but also various forms by applying a plastic injection molding method and using biodegradable polymer materials capable of plastic injection molding. CONSTITUTION: A multi-layered molding device and a method for manufacturing biomaterials having microstructure comprises a first mold layer(10), a second mold layer(20), a third mold layer(30), and an insulation layer(50). The first mold layer comprises a cavity surface which forms a cavity for making microstructure of desired biomaterials by injecting melted biodegradable polymer materials. The second mold layer surrounds the outside of a first mold. The third mold layer surrounds the outside of a second mold. The insulation layer is formed in a boundary of the first mold and the second mold.
Abstract:
The present invention relates to an LED lens for signboard flood light capable of effectively evenly diffusing light emitted from an LED light source to the entire surface of a wide signboard. The LED lens for signboard flood light which irradiates a signboard by light according to the present invention is mounted on the upper part of an LED to evenly diffuse light onto a signboard, which is emitted from the LED. Under the assumption that a horizontal axis traversing a light axis of the LED in a horizontal direction is an x-axis and that a vertical axis traversing the light axis of the LED in a vertical direction is a y-axis, the lens is formed symmetrically based on the y-axis and includes a base surface having an incident surface to which the light emitted from the LED enters, and an exit surface which is formed symmetrically based on the y-axis and diffuses the light, which is emitted from the LED to enter the incident surface, to both sides based on the y-axis, wherein the incident surface is formed symmetrically based on the y-axis and includes a first groove part formed to be long in the y-axis direction.
Abstract:
PURPOSE: A scaffold assembly, a flow type bioreactor, and a system using the scaffold assembly are provided to promote in vitro growth of hematopoietic stem cells or precursor cells. CONSTITUTION: A scaffold assembly comprises one or more nanofiber sheets(20), and multiple scaffolds(10) which are laminated between the nanofiber sheets. The nanofiber sheet is comprised of biodegradable polymer selected from poly(L-lactic acid), poly(D,L-lactic acid), poly(glycolic acid), poly(caprolactone), poly(hydroxyalkanoate), poly dioxanone, poly trimethylene carbonate, their derivative, and copolymer.
Abstract:
The present invention relates to a light guide plate, which can output light vertically without a separate prism or brightness enhancement film (BEF) while having a forward slope structure which can be easily formed from a mold or stamp by injection molding so as to facilitate mass production. According to the present invention, the light guide plate includes: a plate configured to guide light received from side surfaces by an internal total reflection, and having an upper surface with an embossed forward slope structure pattern which are symmetrical with respect to the center in cross section and includes a pair of side surface portions inclined toward the center to the top; a transparent coating layer formed on an upper part of the plate to cover the embossed forward slope structure pattern; and a space part formed between the transparent coating layer and the side surface portion when the transparent coating layer is formed, and configured to output light guided from inside the plate to an upper part by total reflection.
Abstract:
본 발명은 골 조직 재생용 본 칩을 제조하는 방법 및 이에 의하여 제조된 골 조직 재생용 본 칩에 관한 것으로, 구체적으로 생분해성 고분자를 포함하는 고분자 조성물을 용융하는 단계; 미세구조의 골 조직 재생용 본 칩을 제조하기 위한 미세패턴이 형성된 금형의 온도를 상승시키는 단계; 상기 용융된 고분자 조성물을 상기 가열된 금형에 주입하는 단계; 상기 금형을 냉각하는 단계; 및 상기 금형 내의 골 조직 재생용 본 칩을 금형으로부터 분리하는 단계를 포함하는 골 조직 재생용 본 칩을 제조하는 방법 및 이에 의하여 제조된 골 조직 재생용 본 칩을 제공한다.
Abstract:
PURPOSE: A method of preparation of a bone chip for bone tissue regeneration and a bone chip for bone tissue regeneration made by the same are provided to be suitable for mass production and to easily control the shape and size of a bone chip. CONSTITUTION: A method of preparation of a bone chip for bone tissue regeneration comprises: a step of fusing a polymeric composition including a biodegradable polymer; a step of increasing the temperature of a mold in which micro-patterns are formed in order to produce a bone chip for bone tissue regeneration; a step of injecting the fused polymeric composition into a heated mold; a step of cooling the mold; and a step of separating the bone chip from the mold.