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公开(公告)号：KR101422690B1
公开(公告)日：2014-07-23
申请号：KR1020100012744
申请日：2010-02-11
Applicant: (주)차바이오텍
Abstract: 본 발명은 배아줄기세포 유래 혈관형성전구세포 배양액 또는 배양 분비물을 이용한 피부재생용 조성물 및 이의 용도에 관한 것으로, 본 발명은 배아줄기세포 유래 혈관형성전구세포 자체가 아닌 배양 분비물을 치료제로 이용하므로 기형종(teratoma) 형성의 위험성이 없고, 신생혈관 생성능력을 촉진시켜 창상치료, 화상창상치료에 효과적이며, 이를 화장품 원료로 이용하는 경우 콜라겐 생성을 증대시켜 피부노화를 방지하는 효과를 제공한다. 특히, 상기 배양 분비물을 고농도로 농축시킨 본 발명의 조성물은 종래 hGH(human growth hormone)에 비해 높은 창상치료효과를 제공한다.
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Patent Agency Ranking
公开(公告)号：KR1020120042604A
公开(公告)日：2012-05-03
申请号：KR1020110020129
申请日：2011-03-07
CPC classification number: A61M5/329 , A61M5/3291
Abstract: PURPOSE: An injection needle for cell injection and a syringe including thereof are provided to prevent leaking of cell solution which is injected into cardiac muscles by forming an injection needle shaft in a spiral shape. CONSTITUTION: An injection needle for cell injection(10) includes a spiral shaped needle shaft(11). A plurality of openings is formed on side of the injection needle shaft. The needle shaft includes bioabsorbable material in order to decompose within organs. The needle shaft comprises a second shaft of bioabsorbable material which is made of metal and a first shaft. The syringe comprises an injection needle having a spiral shape, an injector barrel which has an injection needle, and a plunger which is inserted into the injector barrel.
Abstract translation: 目的：提供用于细胞注射的注射针和包括其的注射针，以通过形成螺旋形状的注射针轴来防止注射到心肌中的细胞溶液的泄漏。 构成：用于细胞注射的注射针（10）包括螺旋状的针轴（11）。 在注射针轴的侧面上形成有多个开口。 针轴包括生物可吸收材料，以便在器官内分解。 针轴包括由金属制成的生物可吸收材料的第二轴和第一轴。 注射器包括具有螺旋形状的注射针，具有注射针的注射器筒和插入到注射器筒中的柱塞。
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公开(公告)号：KR1020100098298A
公开(公告)日：2010-09-06
申请号：KR1020100012744
申请日：2010-02-11
Applicant: (주)차바이오텍
Abstract: PURPOSE: A composition containing embryonic stem cell-derived endothelial progenitor cell culture liquid or culture secretion is provided to use as a therapeutic agent and to use in wound healing. CONSTITUTION: A composition for skin regeneration contains culture secretion of embryonic stem cell-derived endothelial progenitor cell or fraction thereof as an active ingredient. The embryonic stem cells are human embryonic stem cells. The composition is used in wound healing or skin plastic surgery. The composition contains 1,250-1,250,000 pg/ml of epidermal growth factor(EFG), 35-35,000 pg/ml of basic fibroblast growth factor(FGF-2), 650-650,000 pg/ml of platelet-derived growth factor-AA(PDGF-AA), and 400-400,000 pg/ml of vascular endothelial growth factor(VEGF) as active ingredients.
Abstract translation: 目的：提供含有胚胎干细胞衍生的内皮祖细胞培养液或培养物分泌物的组合物用作治疗剂并用于伤口愈合。 构成：用于皮肤再生的组合物包含胚胎干细胞衍生的内皮祖细胞或其部分作为活性成分的培养物分泌。 胚胎干细胞是人胚胎干细胞。 该组合物用于伤口愈合或皮肤整形手术。 该组合物含有1,250-1,250,000pg / ml表皮生长因子（EFG），35-35,000pg / ml碱性成纤维细胞生长因子（FGF-2），650-650,000pg / ml血小板衍生生长因子-Ag -AA）和400-400,000pg / ml血管内皮生长因子（VEGF）作为活性成分。
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公开(公告)号：KR101322673B1
公开(公告)日：2013-10-30
申请号：KR1020110020129
申请日：2011-03-07
CPC classification number: A61M5/329 , A61M5/3291
Abstract: 본 발명은 심근경색 또는 허혈성 심부전 질환으로 괴사된 심근조직 내에 줄기세포를 주입하기 위한 주사바늘 및 주사기에 관한 것으로, 본 발명은 주사바늘 샤프트(needle shaft)가 나선형으로 감겨진 형태인 세포주입용 주사바늘을 제공한다. 본 발명이 주사바늘 및 주사기는 심근조직에 주입 후 세포액이 심장외막 밖으로 새어나오는 것을 방지함과 동시에, 주입된 줄기세포에 혈류 순환을 재개시킴으로써 괴사된 심근조직 내에 줄기세포 생존율을 증가시킬 수 있다.
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公开(公告)号：KR1020120063377A
公开(公告)日：2012-06-15
申请号：KR1020100124510
申请日：2010-12-07
Applicant: (주)차바이오텍
IPC: C12Q1/24 , C12N5/0775
Abstract: PURPOSE: A method for isolating and culturing mesenchymal cells from embryonic stem cells is provided to cheaply isolate and culture mesenchymal cells. CONSTITUTION: A method for isolating and culturing mesenchymal cells comprises: a step of culturing embryonic stem cells or embryonic stem cell-derived embryoid body in a cell culture insert with a porous membrane; a step of isolating mesenchymal cells; and a step of culturing the mesenchymal cells. The embryonic stem cells are derived from mammal.
Abstract translation: 目的：提供从胚胎干细胞中分离和培养间充质细胞的方法，以廉价分离和培养间充质细胞。 构成：分离和培养间充质细胞的方法包括：在具有多孔膜的细胞培养插入物中培养胚胎干细胞或胚胎干细胞衍生的胚状体的步骤; 分离间充质细胞的步骤; 和培养间充质细胞的步骤。 胚胎干细胞来源于哺乳动物。
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公开(公告)号：KR101760239B1
公开(公告)日：2017-07-24
申请号：KR1020100124510
申请日：2010-12-07
Applicant: (주)차바이오텍
IPC: C12Q1/24 , C12N5/0775
Abstract: 본발명은배아줄기세포로부터중간엽세포를분리, 배양하는방법에관한것으로, 더욱상세하게는세포배양삽입체를이용하여다분화능력을가진중간엽세포를효과적으로분리, 배양하는방법및 상기방법에의해분리된중간엽세포에관한것이다. 본발명의분리방법은다른물질의첨가없이세포배양삽입체만을이용하여배아발생중 일어나는현상을시험관내에서자연스럽게유도하여, 배아줄기세포로부터중간엽줄기세포를포함한중간엽세포를저비용으로, 단시간에효과적으로분리, 배양하는방법이다.
Abstract translation: 本发明分离的间充质细胞，一种用于培养，更特别是细胞有效地通过使用培养插管，培养物的方法和从胚胎干细胞的方法的与分化能力的间充质细胞中分离 由本发明的分离涉及间充质细胞。 以较低的成本，本发明的分离方法的间充质细胞，包括仅使用一个细胞培养插管在不添加其他物质自然体外生成胚胎，胚胎干细胞，的现象在短时间内充质干细胞从通过感应 有效地分离和培养细胞。
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