公开(公告)号：KR1020110138917A

公开(公告)日：2011-12-28

申请号：KR1020100059095

申请日：2010-06-22

Applicant: 가톨릭대학교 산학협력단

Inventor： 천명훈 ,  오수자 ,  김천호 ,  김가희

IPC: C08J3/28 ,  C08J7/18 ,  C08L101/16 ,  A61K9/06

Abstract: PURPOSE: A molecular weight regulation method for a biodegradable polymer is provided to use the sonication for decomposing the biodegradable polymer without generating cytotoxic material. CONSTITUTION: A molecular weight regulation method for a biodegradable polymer comprises the following steps: low temperature storing the biodegradable polymer at 0-10 deg C for 0-48 hours after dissolving in a solvent; and reducing the molecular weight of the biodegradable polymer by adjusting the application time and the applied voltage intensity of ultrasonic waves at 0-4 deg C. The biodegradable polymer is a natural polymer selected from hyaluronic acid, chitoic acid, chitin, alginic acid, heparin, starch, xanthan, pullulan, or polyamino acid.

Abstract translation: 目的：提供生物可降解聚合物的分子量调节方法，使用超声处理分解可生物降解聚合物，而不产生细胞毒性物质。 构成：可生物降解聚合物的分子量调节方法包括以下步骤：将溶解于溶剂中的0〜48小时后，将生物降解性聚合物低温储存0〜48小时。 并通过调节超声波在0-4℃的施加时间和施加的电压强度来降低可生物降解的聚合物的分子量。可生物降解的聚合物是选自透明质酸，壳聚酸，甲壳质，藻酸，肝素的天然聚合物 ，淀粉，黄原胶，支链淀粉或聚氨基酸。