公开(公告)号：KR101356320B1

公开(公告)日：2014-01-28

申请号：KR1020130011219

申请日：2013-01-31

Applicant: 가톨릭대학교 산학협력단

Inventor： 나건 ,  우영롱

IPC: A61K47/36 ,  A61K31/719 ,  A61L27/52 ,  A61L27/20 ,  A61L27/54

CPC classification number: A61K47/36 ,  A61K31/719 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54

Abstract: The present invention relates to a skin filler composition and, more specifically, to a skin filler composition containing hyaluronic acid gel, comprising pullulan acetate microspheres, as an active ingredient. Since the skin filler composition in the present invention contains the hyaluronic acid gel comprising the pullulan acetate microspheres, the degradation speed of the hyaluronic acid gel is much slower than hyaluronic acid gel itself, thereby being stable in vivo for a long time. Also, the hyaluronic acid gel comprising the pullulan acetate microspheres gives viscoelasticity to the skin since it is more viscous than the existing hyaluronic acid gels, improving roles of cushioning a blow and buffer, promoting the production of main components including collagen, and helping the components to maintain skin tissues. Thus, the skin filler composition in the present invention will be very valuable as a semipermanent filler material with biocompatibility. [Reference numerals] (AA) Cell viability(%); (BB) Hyaluronic acid; (CC) Hyaluronic acid bridge gel; (DD) Hyaluronic acid bridge gel including PA microspheres

Abstract translation: 本发明涉及皮肤填充剂组合物，更具体地，涉及包含透明质酸凝胶的皮肤填充剂组合物，其包含作为活性成分的醋酸支链淀粉微球。 由于本发明的皮肤填充剂组合物含有包含支链淀粉的微球的透明质酸凝胶，因此透明质酸凝胶的降解速度比透明质酸凝胶本身慢得多，因此在体内长时间稳定。 此外，包含支链淀粉的微球的透明质酸凝胶由于其比现有的透明质酸凝胶更粘稠，改善缓冲冲击和缓冲剂的作用，促进包括胶原蛋白在内的主要成分的生产，并帮助组分 保持皮肤组织。 因此，本发明的皮肤填充剂组合物作为具有生物相容性的半永久性填充材料是非常有价值的。 （AA）细胞活力（％）; （BB）透明质酸; （CC）透明质酸桥凝胶; （DD）透明质酸桥凝胶，包括PA微球