公开(公告)号：KR1020110031529A

公开(公告)日：2011-03-29

申请号：KR1020090088825

申请日：2009-09-21

Applicant: 강릉원주대학교산학협력단

Inventor： 손영창 ,  진덕희 ,  김미애

IPC: C07K14/435 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C07K14/43504 ,  G01N33/5008 ,  G01N2500/00

Abstract: PURPOSE: A method for screening a material which is useful in controlling nuclear receptor transcription using Sn-SRC gene is provided to study transcriptional mechanism of a specific nuclear receptor. CONSTITUTION: A Stronglocentrotus nudus Sn-SRC has an amino acid sequence of sequence number 1 or 2. A Sn-SRC gene encodes the amino acid. A composition for preventing or treating metabolic disease or cancer contains the Sn-SRC protein, fragment, mutant, derivative, allele mutant thereof, or peptide derived from the same. A method for screening a material which suppresses or promotes nuclear receptor and ligand binding comprises: a step of searching and isolating the material which suppresses or promotes nuclear receptor and ligand binding; and a step of measuring the activity of the searched material with respect to the nuclear receptor to select a material which suppresses or promotes nuclear receptor and ligand binding.

Abstract translation: 目的：提供一种用于筛选使用Sn-SRC基因控制核受体转录的材料的方法，以研究特异性核受体的转录机制。 构成：Strongrocentrotus nudus Sn-SRC具有序列号1或2的氨基酸序列.Sn-SRC基因编码氨基酸。 用于预防或治疗代谢疾病或癌症的组合物含有Sn-SRC蛋白，其片段，突变体，衍生物，等位基因突变体或衍生自其的肽。 筛选抑制或促进核受体和配体结合的物质的方法包括：检测和分离抑制或促进核受体和配体结合的物质的步骤; 以及测量所搜索的材料相对于核受体的活性以选择抑制或促进核受体和配体结合的材料的步骤。