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1.发明公开감태(Ｅｃｋｌｏｎｉａ ｃａｖａ )유래 마이톨과 ｆｕｃｏｉｄａｎ의 혼합물을 유효성분으로 함유하는 아토피 피부염 개선용 화장료 조성물 有权用于抗真菌皮肤成分的化妆品组合物，其包含作为从ECKLONIA CAVA分离的有效成分的MITOL和FUCOIDAN混合物
公开(公告)号：KR1020120138308A
公开(公告)日：2012-12-26
申请号：KR1020110057676
申请日：2011-06-14
Applicant: 강릉원주대학교산학협력단
CPC classification number: A61K8/9706 , A61K8/73 , A61K36/03 , A61Q19/00 , Y10S514/857
Abstract: PURPOSE: A composition containing Ecklonia cava-derived mitol and fucoidan and an external use skin formulation are provided to ensure an anti-inflammatory effect and to treat atopic dermatitis. CONSTITUTION: A composition with an anti-inflammatory effect contains 0.3 wt% of Ecklonia cava-derived mitol and 0.5-2 wt% of fucoidan. The mitol contains polyphenol derived from Ecklonia cava as an active ingredient. A method for preparing fucoidan comprises: a step of drying Ecklonia cava and extracting Ecklonia cava with 80% ethyl alcohol at room temperature for 12 hours; a step of centrifuging the extract and collect pellet; a step of mixing the pellet with 80% ethyl alcohol and stirring at room temperature for 12 hours; a step of centrifuging and collecting pellet; a step of removing pigment, lipid, and low molecular proteins using acetone and drying to prepare Ecklonia cava powder; a step of adding distilled water to the Ecklonia cava powder and extracting at 60 Deg.C. for 2 hours, centrifuging, and collecting supernatant; a step of adding CaCl_2 to supernatant and incubating at 4 Deg.C. for 18 hours; a step of centrifuging and collecting supernatant; and a step of concentrating the supernatant and adding ethyl alcohol.
Abstract translation: 目的：提供含有Ecklonia cava-derived mitol和岩藻多糖和外用皮肤制剂的组合物，以确保抗炎作用和治疗特应性皮炎。 构成：具有抗炎作用的组合物含有0.3重量％的Ecklonia cava来源的丝胶和0.5-2wt％的岩藻依聚糖。 丝裂霉素含有源自Ecklonia cava的多酚作为活性成分。 制备岩藻依聚糖的方法包括：在室温下干燥Ecklonia cava并用80％乙醇提取Ecklonia cava 12小时的步骤; 离心提取物并收集颗粒的步骤; 将沉淀物与80％乙醇混合并在室温下搅拌12小时的步骤; 离心收集颗粒的步骤; 使用丙酮除去颜料，脂质和低分子蛋白并干燥以制备Ecklonia cava粉末的步骤; 向Ecklonia Cava粉末加入蒸馏水并在60℃下萃取的步骤。 2小时，离心，收集上清液; 将CaCl_2加入上清液中并在4℃下孵育的步骤。 18个小时; 离心收集上清液的步骤; 和浓缩上清液并加入乙醇的步骤。
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2.发明授权감태(Ｅｃｋｌｏｎｉａ ｃａｖａ )유래 마이톨과 ｆｕｃｏｉｄａｎ의 혼합물을 유효성분으로 함유하는 아토피 피부염 개선용 화장료 조성물 有权用于抗特应性皮肤病的化妆品组合物，其包含分离自Ecklonia cava的有效成分的mitol和岩藻依聚糖混合物
公开(公告)号：KR101379460B1
公开(公告)日：2014-03-31
申请号：KR1020110057676
申请日：2011-06-14
Applicant: 강릉원주대학교산학협력단
Abstract: 본 발명은 갈조류 감태(Ecklonia cava) 유래 마이톨과 fucoidan을 유효성분으로 포함하는 항염증 활성 조성물 및 아토피 피부염 개선용 외용제에 관한 것으로, 본 발명에 따른 화장료 조성물은 마이톨과 fucoidan을 각각 단독으로 사용하는 것보다 높은 시너지 효과를 나타낸다.
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