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公开(公告)号：KR101360226B1
公开(公告)日：2014-02-12
申请号：KR1020110114685
申请日：2011-11-04
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 동물의 전신으로 계면활성제를 관류시는 단계를 포함하는 심폐 일체형 바이오스캐폴드를 제조하는 방법 및 상기 방법으로 제조된 심폐 일체형 바이오스캐폴드에 관한 것이다. 장기이식 대기자 중에 심장이식 대상자의 많은 수가 심폐의 일체형 이식을 요구하고 있으며, 폐는 장기의 구조 및 특성상 타장기와 동시에 탈세포화 시키기 힘든바, 본 발명의 심폐 일체형으로 유지하면서 탈세포화 시키는 방법은 이러한 심폐장기이식이 필요한 환자에게 유용하게 이용될 수 있다.
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公开(公告)号：KR1020130049585A
公开(公告)日：2013-05-14
申请号：KR1020110114685
申请日：2011-11-04
Applicant: 강원대학교산학협력단
CPC classification number: A61L27/3695 , A61L2430/40 , A61M1/36 , A61M25/00 , A61M31/00
Abstract: PURPOSE: A method for decellularization from heart and lung is provided to enable decellularization from heart and lung which are anatomically and functionally combined, and to use for a patient who needs heart and lung transplantation. CONSTITUTION: A method for decellularization from heart and lung comprises: a step of perfusing a surfactant through carotid artery; a step of perfusing the surfactant through portal vein a predetermined time after the perfusion through carotid artery; and a step of perfusing the surfactant through front mesentery artery and aorta and vena cava of the rear portion renal vein. [Reference numerals] (AA) Normal heart, lung; (BB) Heart; (CC) Lung; (DD) Scaffold heart, lung
Abstract translation: 目的：提供从心脏和肺部脱细胞化的方法，使解剖和功能组合的心脏和肺的脱细胞化，并用于需要心脏和肺移植的患者。 构成：从心脏和肺部脱细胞化的方法包括：通过颈动脉灌注表面活性剂的步骤; 在通过颈动脉灌注预定时间后通过门静脉灌注表面活性剂的步骤; 以及通过前部肠系膜动脉和后部肾静脉的主动脉和腔静脉灌注表面活性剂的步骤。 （标号）（AA）正常心脏，肺; （BB）心; （CC）肺; （DD）支架心脏，肺
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公开(公告)号：KR1020140046858A
公开(公告)日：2014-04-21
申请号：KR1020120113037
申请日：2012-10-11
Applicant: 강원대학교산학협력단
IPC: A61D1/00 , A61F2/10 , A61B17/322 , A61D7/00
CPC classification number: A61D1/00 , A61B17/322 , A61D7/00 , A61F2/105
Abstract: The present invention relate to a skin transplantation method for facilitating a collection of skin tissue comprising transplants when transplanting an animal skin. When using the skin transplantation method according to the present invention, a graft is firmly fixed to an implant site whereby risk of loss is small; and abundant samples can be acquired from a small number of animals, thereby enabling an effective application in research of transplant rejection in animals, etc.
Abstract translation: 本发明涉及一种皮肤移植方法，用于在移植动物皮肤时促进包含移植物的皮肤组织的收集。 当使用根据本发明的皮肤移植方法时，移植物牢固地固定到植入部位，由此损失的风险小; 可以从少量动物获得丰富的样品，从而有效应用于动物等中的移植排斥研究。
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Patent Agency Ranking
公开(公告)号：KR1020130086734A
公开(公告)日：2013-08-05
申请号：KR1020120007634
申请日：2012-01-26
Applicant: 강원대학교산학협력단
CPC classification number: A61L27/56 , A61L27/38 , A61L2430/28 , A61L2430/40
Abstract: PURPOSE: A method for removing heterologous immunogens and retrovirus from a bioscaffold is provided to prevent acute immune rejection or infection of retrovirus. CONSTITUTION: A method for removing heterologous immunogens and retrovirus from a bioscaffold comprises the following steps: preparing an internal organ to make a bioscaffold; and dipping the internal organ in a surfactant. The internal organ is the liver of a pig. The surfactant is 0.1-0.25% concentration of sodium dodecyl sulfate.
Abstract translation: 目的：提供从生物支架中去除异源免疫原和逆转录病毒的方法，以防止急性免疫排斥反应或感染逆转录病毒。 构成：从生物支架中除去异源免疫原和逆转录病毒的方法包括以下步骤：制备内部器官以制备生物支架; 并将内部器官浸入表面活性剂中。 内脏是猪的肝脏。 表面活性剂的浓度为0.1-0.25％十二烷基硫酸钠。
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公开(公告)号：KR1020130007489A
公开(公告)日：2013-01-18
申请号：KR1020120113087
申请日：2012-10-11
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A manufacturing method of bio scaffold is provided to remove major heteroimmunity antigen and manhole cask virus pathogen. CONSTITUTION: A manufacturing method of bio scaffold comprises the following steps: preparing an organ which will be manufactured into bio scaffold; and dipping the organ into SDS (sodium dodecyl sulfate). The organ is selected from a group consisting of anthropoid, pig, cow, sheep, and goat. When the organ is belong to pig, liver is used. The concentration of the SDS is 0.05-0.25 %.
Abstract translation: 目的：提供生物支架的制造方法，以去除主要的异种免疫抗原和人孔病毒病毒病原体。 构成：生物支架的制造方法包括以下步骤：制备将制成生物支架的器官; 并将器官浸入SDS（十二烷基硫酸钠）中。 器官选自人类，猪，牛，绵羊和山羊。 当器官属于猪时，使用肝脏。 SDS的浓度为0.05-0.25％。
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公开(公告)号：KR1020150039231A
公开(公告)日：2015-04-10
申请号：KR1020130116579
申请日：2013-09-30
Applicant: 강원대학교산학협력단
CPC classification number: A61L27/56 , A61L27/38 , A61L27/54 , A61L2430/00 , A61L2430/40
Abstract: 본발명은생분해성의이종면역원이제거된바이오스캐폴드및 이의제조방법에관한것이다. 본발명에따른바이오스캐폴드는동물의장기를탈세포화시켜생분해성이있고, 이종면역원이효과적으로제거됨으로써, 생물학적활성 (bioactive) 및생분해성 (biodegradable)이있고, 면역원이제거되어장기를모사할수 있는 3차원모델로재생의학분야에서장기형성 (organogenesis), 약물스크리닝, 면역관련등의많은연구에이용될수 있다.
Abstract translation: 本发明涉及一种可生物降解的异种免疫原生物支架及其制造方法。 根据本发明的生物支架具有通过使动物器官脱细胞化的生物降解性，具有生物活性和可生物降解的特性，因为异源免疫原被有效地除去，并且可以用作复制器官的三维模型，用于各种研究，例如 因为免疫原被去除，所以在再生医疗领域中的无机体，药物筛选，免疫等。
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公开(公告)号：KR1020140046896A
公开(公告)日：2014-04-21
申请号：KR1020120113102
申请日：2012-10-11
Applicant: 강원대학교산학협력단
CPC classification number: A61L27/3604 , A61L27/38 , A61L27/54 , A61L27/56 , A61L2430/00
Abstract: The present invention relates to a production method of a bio-scaffold using an SDS solution. A 0.1% SDS cell-detaching solution of the present invention has excellent shape and microstructure preserving properties when producing the bio-scaffold, and an excellent rapid cell-detaching effect of organ tissues from animals, thereby being practically used for producing the bio-scaffold.
Abstract translation: 本发明涉及使用SDS溶液的生物支架的制造方法。 本发明的0.1％SDS细胞分离溶液在制备生物支架时具有优异的形状和微结构保存性能，并且具有优异的动物器官组织的快速细胞分离作用，从而实际用于生产生物支架 。
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