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公开(公告)号：KR1020080057635A
公开(公告)日：2008-06-25
申请号：KR1020060131190
申请日：2006-12-20
Applicant: 강원대학교산학협력단
IPC: C07D205/08 , C07D403/04
CPC classification number: C07D205/08 , C07D403/08
Abstract: A 4-alkenyl-2-azetidinone derivative is provided to have a novel structure of introducing 1,3-diene-2-yl or 1,2,4,5-hexatetraene-3-yl into a C-4 position of beta-lactam, thereby being usefully used as a diene reaction material for a Diels-Alder reaction. A 4-alkenyl-2-azetidinone derivative is represented by a formula(1), wherein Q is CH or C=CH; R^1 is H, or C1-6 hydroxyalkyl or protected hydroxyalkyl; and R^2 is H, C1-6 alkyl, or phenyl. A method for preparing the derivative of the formula(1) comprises the steps of: (a) reacting a propargyl halide derivative represented by a formula(2) with indium to prepare an organic indium reagent represented by a formula(3); and (b) reacting the reagent of the formula(3) with 4-acetoxy-2-azetidinone represented by a formula(4) to prepare the derivative of the formula(1), wherein X is halogen; Y is -C- or -C-C=C-; n is 0 or 2; and Q, R^1, and R^2 are same as defined above. A method for preparing a multicyclic compound represented by a formula(6a) or (6b) comprises a step of subjecting the compound of the formula(1) and a dienophile represented by a formula(5a) or (5b) to Diels-Alder reaction, wherein Q, R^1, and R^2 are same as defined above; and each E^1, E^2, E^3, E^4, E^5, and E^6 is H, cyano, C(O)R, C(O)OR, or C(O)NR2(wherein R is H or C1-6 alkyl).
Abstract translation: 提供4-链烯基-2-氮杂环丁酮衍生物以具有将1,3-二烯-2-基或1,2,4,5-六四烯-3-基引入C 1 -C 4的C-4位的新结构， 内酰胺，因此可用作Diels-Alder反应的二烯反应物质。 4-烯基-2-氮杂环丁酮衍生物由式（1）表示，其中Q是CH或C = CH; R 1是H或C 1-6羟基烷基或被保护的羟烷基; R 2是H，C 1-6烷基或苯基。 制备式（1）的衍生物的方法包括以下步骤：（a）使由式（2）表示的炔丙基卤化物衍生物与铟反应以制备由式（3）表示的有机铟试剂; 和（b）使式（3）的试剂与由式（4）表示的4-乙酰氧基-2-氮杂环丁酮反应以制备式（1）的衍生物，其中X是卤素; Y是-C-或-C-C = C-; n为0或2; 并且Q，R 1和R 2与上述定义相同。 制备由式（6a）或（6b）表示的多环化合物的方法包括使式（1）的化合物和由式（5a）或（5b）表示的双亲体的狄尔斯 - 阿尔德反应 其中Q，R 1和R 2与上述定义相同; 并且每个E ^ 1，E ^ 2，E ^ 3，E ^ 4，E ^ 5和E ^ 6是H，氰基，C（O）R，C（O）OR或C（O）NR 2 其中R是H或C 1-6烷基）。
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公开(公告)号：KR100927242B1
公开(公告)日：2009-11-16
申请号：KR1020080003208
申请日：2008-01-10
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 알릴알렌 유도체와 이의 제조방법에 관한 것으로서, 더욱 상세하게는 알릴 할라이드 유도체와 인듐(indium)을 반응시켜 알릴인듐 시약을 제조한 후 프로파질 알코올 유도체와 치환 반응하여 제조된 하기 화학식 1로 표시되는 알릴알렌 유도체와 이의 제조방법에 관한 것이다.
상기 화학식 1에서, R
1 , R
2 , R
3 및 R
4 는 각각 발명의 상세한 설명에서 정의한 바와 같다.
알릴알렌, 프로파질 알코올, 인듐, 알릴할라이드, 알릴인듐Abstract translation: 本发明是由Allen衍生物烯丙基作为其涉及一种方法，用于制备，更具体地说，通过与炔丙基醇衍生物的取代反应制备下列通式1制备铟试剂烯丙基的烯丙基卤衍生物和铟（铟）反应 及其制造方法。
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公开(公告)号：KR1020090077335A
公开(公告)日：2009-07-15
申请号：KR1020080003208
申请日：2008-01-10
Applicant: 강원대학교산학협력단
Abstract: A method for preparing an allyl allene derivative is provided to synthesize an allyl allene derivative at good yield by reacting an allyl indium reagent with a propargyl alcohol derivative without a separate refining process. A method for preparing an allyl allene derivative has a structure of chemical formula 1. In the chemical formula 1, R1 and R2 show C1-C6 alkyl group, or substituted or unsubstituted phenyl group, or R1 and R2 form 5-8-membered cycloalkyl ring; R3 and R4 show hydrogen atom, C1-C6 alkyl group, substituted or unsubstituted phenyl group, or phenyl-C1-C6 alkylene group. The substituted phenyl group is a phenyl group substituted with substituents selected from halide, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, ketone, ester, nitro, amide, aldehyde and amine.
Abstract translation: 提供烯丙基丙烯衍生物的制备方法，通过使烯丙基铟试剂与炔丙醇衍生物反应而不用单独的精制方法，以良好的收率合成烯丙基全烯衍生物。 制备烯丙基全烯衍生物的方法具有化学式1的结构。在化学式1中，R 1和R 2表示C 1 -C 6烷基或取代或未取代的苯基，或R 1和R 2形成5-8元环烷基 环; R3和R4表示氢原子，C1-C6烷基，取代或未取代的苯基或苯基-C1-C6亚烷基。 取代的苯基是被选自卤素，羟基，C 1 -C 6烷基，C 1 -C 6烷氧基，酮，酯，硝基，酰胺，醛和胺的取代基取代的苯基。
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公开(公告)号：KR100884654B1
公开(公告)日：2009-02-23
申请号：KR1020060131190
申请日：2006-12-20
Applicant: 강원대학교산학협력단
IPC: C07D205/08 , C07D403/04
CPC classification number: C07D205/08 , C07D403/08
Abstract: 본 발명은 하기 화학식 1로 표시되는 4-알케닐-2-아제티디논 유도체와 이의 제조방법 및 이 화합물을 이용하여 제조된 다중고리화합물에 관한 것이다.
상기 화학식 1에서, Q, R
1 및 R
2 는 각각 발명의 상세한 설명에서 정의한 바와 같다.
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