公开(公告)号：KR101412876B1

公开(公告)日：2014-06-26

申请号：KR1020130015527

申请日：2013-02-13

Applicant: 경희대학교 산학협력단

Inventor： 박헌국 ,  남성원 ,  최삼진 ,  정유진

IPC: A61B5/03 ,  A61B5/026

Abstract: The present invention relates to a microfluidic chip for a human cerebrovascular model including a channel layer having micro channels patterned to be an artery vascular structure with a circle of Willis for a human on a substrate and a valve layer having a valve which may independently control a fluid flow in each artery; a cerebral blood flow measurement system including the microfluidic chip, a fluid inputting part and a blood flow measurement part; and a method to assess the degree of risk of a cerebrovascular disease using the microfluidic chip or the cerebral blood flow measurement system. The microfluidic chip including the valve layer which may independently adjust each channel and the cerebral blood flow measurement system using the same patterns as a clinical cerebrovascular model obtained from a real human to manufacture the micro channels, wherein the micro channel has a length and a diameter of a blood vessel in proportion to a clinical cerebrovascular standard, so as to stimulate a numeral value range of the clinical blood flow with high precision in a case of injecting a fluid with a ratio similar to a clinical case. Additionally, the present invention may simulate a cerebral infarction blood flow because opening or closing an individual artery blood vessel is possible using the valve, so as to estimate the degree of risk of a cerebrovascular disease occurrence and an estimated disease occurrence portion due to the infarction of a specific blood vessel.

Abstract translation: 本发明涉及一种用于人脑血管模型的微流体芯片，其包括具有图案化为具有在基底上的人的Willis圆的动脉血管结构的微通道的通道层，以及具有可独立控制 每个动脉中的流体流动; 包括微流体芯片的脑血流量测量系统，流体输入部和血流测量部; 以及使用微流体芯片或脑血流量测量系统来评估脑血管疾病风险程度的方法。 该微流体芯片包括可以独立地调整每个通道的阀层和使用与从真实人获得的临床脑血管模型相同的图案来制造微通道的脑血流量测量系统，其中微通道具有长度和直径 与临床脑血管标准成比例的血管，以在以与临床情况相似的比例注射流体的情况下以高精度刺激临床血流的数值范围。 此外，本发明可以模拟脑梗死血流，因为可以使用瓣膜打开或关闭单个动脉血管，以便估计由脑梗死引起的脑血管疾病发生的风险程度和估计的疾病发生部分 的特定血管。