公开(公告)号：KR101623209B1

公开(公告)日：2016-05-23

申请号：KR1020090096746

申请日：2009-10-12

Applicant: 경희대학교 산학협력단

Inventor： 류종훈 ,  김동현 ,  김현수 ,  최재수 ,  현숙경 ,  박호재 ,  정재성 ,  신범영

IPC: A61K31/122 ,  A61K36/482 ,  A61P25/28 ,  A23L1/30

Abstract: 본발명은건망증개선및 치매치료효과를갖는조성물에관한것으로서, 본발명의콩과에속하는결명자(Cassia tora) 또는초결명(Cassia obtusifolia)에서분리된화합물들은베타씨크리타아제 (β-secretase)를억제하고스코폴라민에의해유도된기억력감퇴동물군의학습증진효능을나타냄으로써, 인지기능장애의예방및 치료를위한약학조성물및 건강기능식품으로유용하게이용될수 있다.

公开(公告)号：KR1020070118450A

公开(公告)日：2007-12-17

申请号：KR1020060052615

申请日：2006-06-12

Applicant: 경희대학교 산학협력단

Inventor： 류종훈 ,  김선여 ,  오혜림 ,  현성예 ,  이승주 ,  김동현 ,  김현수 ,  박호재 ,  정재성

IPC: A61K36/8964 ,  A61P25/28

Abstract: A composition comprising the extract of Anemarrhenae rhizoma is provided to inhibit coagulation of platelet without side effects, so that it is useful for prevention or treatment of ischemic brain stroke caused by neurodegenerative damage. A composition for prevention or treatment of ischemic brain stroke comprises 0.5-50 wt.% of the extract of Anemarrhenae rhizoma which is prepared by extracting Anemarrhenae rhizoma with water, lower alcohol such as methanol, ethylalcohol, propanol and butanol or a mixed solvent thereof and contains anemarsaponin B. The composition is a pharmaceutical or health food composition and the pharmaceutical composition is formulated as powder, granule, tablet, capsule, solution or injection.

Abstract translation: 提供了包含Anemarrhenae rhizoma提取物的组合物以抑制血小板的凝血而没有副作用，因此其可用于预防或治疗由神经变性损伤引起的缺血性脑卒中。 用于预防或治疗缺血性脑卒中的组合物包含0.5-50重量％的Anemarrhenae根茎提取物，其通过用水，低级醇如甲醇，乙醇，丙醇和丁醇或其混合溶剂提取Anemarrhenae rhizoma而制备， 该组合物是药物或保健食品组合物，药物组合物配制成粉末，颗粒，片剂，胶囊，溶液或注射剂。

公开(公告)号：KR1020110039762A

公开(公告)日：2011-04-20

申请号：KR1020090096746

申请日：2009-10-12

Applicant: 경희대학교 산학협력단

Inventor： 류종훈 ,  김동현 ,  김현수 ,  최재수 ,  현숙경 ,  박호재 ,  정재성 ,  신범영

IPC: A61K31/122 ,  A61K36/482 ,  A61P25/28 ,  A23L1/30

Abstract: PURPOSE: A composition for treating dementia and amnesia is provided to suppress beta-secretase and to be used as a pharmaceutical composition and health food. CONSTITUTION: A pharmaceutical composition for preventing and treating cognitive disorder contains a compound of general formula I as an active ingredient, isolated from Cassia obtusifolia or Cassia tora. The compound is gluco-obtusifolin, gluco-aurantio-obtusin, alaternin, or chrysophanoltriglucoside. The pharmaceutical composition for preventing and treating cognitive disorder contains a compound of general formula II isolated from Cassia obtusifolia or Cassia tora.

Abstract translation: 目的：提供用于治疗痴呆和遗忘症的组合物以抑制β-分泌酶并用作药物组合物和保健食品。 构成：用于预防和治疗认知障碍的药物组合物含有通式I化合物作为活性成分，分离自桂皮（Cassia obtusifolia）或决明子（Cassia tora）。 该化合物是葡萄糖 - 戊聚糖，葡萄糖 - 奥曲汀 - 黑曲霉素，alaternin或chrysophanol triglucoside。 用于预防和治疗认知障碍的药物组合物含有从仙客子（Cassia obtusifolia）或决明子（Cassia tora）分离的通式II的化合物。