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    이리도이드 배당체를 함유하는 항산화제 및 약학적 조성물
    1.
    发明公开
    이리도이드 배당체를 함유하는 항산화제 및 약학적 조성물 失效
    包含红斑狼疮的抗氧化剂和包含其的药物组合物

    公开(公告)号：KR1020070070308A

    公开(公告)日：2007-07-04

    申请号：KR1020050079888

    申请日：2005-08-30

    Applicant: 경희대학교 산학협력단

    Inventor： 김동현 ,  오영준 ,  백남인 ,  정태숙 ,  김민정 ,  김성훈 ,  이효정

    IPC: A61K31/7048 ,  A61K36/748 ,  A61P39/06

    CPC classification number: A61K31/7048 ,  A61K36/748 ,  A61K2236/30 ,  A61K2236/55 ,  Y10S514/824

    Abstract: An anti-oxidant comprising iridoid glycosides and a pharmaceutical composition comprising the same anti-oxidant are provided to inhibit oxidation of LDL(low-density lipoprotein), so that the anti-oxidant is useful for prevention and treatment of cardiovascular diseases caused by LDL oxidation. The anti-oxidant comprises iridoid glycosides represented by the formula(1) and isolated from Oldenlandia diffusa Roxb., wherein R1 and R2 are each independently hydrogen, hydroxyl or optionally hydroxy substituted C1-C5 alkyl; R3 is hydrogen or methyl; R4 is hydrogen, optionally carboxylic acid-substituted C1-C5 alkyl, optionally carboxylic acid-substituted phenyl or optionally carboxylic acid-substituted benzyl; and R5 is Glc or Glc-Ara. The pharmaceutical composition for preventing or treating cardiovascular diseases comprises the iridoid glycosides represented by the formula(1), wherein the cardiovascular diseases include hyperlipidemia, coronary heart disease, atherosclerosis, atherosclerosis and myocardial infarction. The iridoid glycosides represented by the formula(1) is produced by (a) extracting Oldenlandia diffusa Roxb. with C1-C5 organic solvent, (b) fractionating the extract of Oldenlandia diffusa Roxb. with water, ethanol and n-butanol sequentially, and (c) subjecting the n-butanol fraction to chromatography.

    Abstract translation: 提供包含环烯醚萜苷的抗氧化剂和包含相同抗氧化剂的药物组合物以抑制LDL（低密度脂蛋白）的氧化，使得抗氧化剂可用于预防和治疗由LDL氧化引起的心血管疾病 。 抗氧化剂包括由式（1）表示的并且分离自阿尔德兰德氏菌属Roxb的环烯醚萜苷，其中R 1和R 2各自独立地为氢，羟基或任选的羟基取代的C 1 -C 5烷基; R3是氢或甲基; R 4是氢，任选地羧酸取代的C 1 -C 5烷基，任选地羧酸取代的苯基或任选的羧酸取代的苄基; R5是Glc或Glc-Ara。 用于预防或治疗心血管疾病的药物组合物包括由式（1）表示的环烯醚萜苷，其中心血管疾病包括高脂血症，冠心病，动脉粥样硬化，动脉粥样硬化和心肌梗死。 由式（1）表示的环烯醚萜糖苷通过（a）提取古老的en usa usa is is制成。 用C1-C5有机溶剂，（b）分离Oldenlandia diffusa Roxb的提取物。 依次用水，乙醇和正丁醇，和（c）使正丁醇级分进行色谱。

    산딸나무 열매 추출물, 산딸나무 열매 분획물, 이로부터 분리된 트리테르펜계 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 고콜레스테롤혈증에 기인하는 심혈관 질환의 예방 및 치료용 약학적 조성물
    4.
    发明公开
    산딸나무 열매 추출물, 산딸나무 열매 분획물, 이로부터 분리된 트리테르펜계 화합물 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 고콜레스테롤혈증에 기인하는 심혈관 질환의 예방 및 치료용 약학적 조성물 失效
    用于预防和治疗由包含水果的大肠杆菌CaOUS KOUSA BURG引起的心血管疾病的药物组合物。 提取物，分离物，其分离的三磷酸化合物或作为活性成分的药物可接受的盐

    公开(公告)号：KR1020110018671A

    公开(公告)日：2011-02-24

    申请号：KR1020090076256

    申请日：2009-08-18

    Applicant: 경희대학교 산학협력단

    Inventor： 백남인 ,  이대영 ,  정낙훈 ,  이민호 ,  노영덕 ,  정태숙 ,  이윤형

    IPC: A61K36/40 ,  A61K31/19 ,  A61K31/56 ,  A61P3/06

    CPC classification number: A61K36/73 ,  A23V2200/326 ,  A23V2200/3262 ,  A61K2236/33 ,  Y10S514/824

    Abstract: PURPOSE: A pharmaceutical composition containing Cornus kousa Burg. fruit extract is provided to suppress human acyl-CoA(hACAT) and to prevent and treat cardiovascular diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating cardiovascular diseases due to hypercholesterolemia contains Cornus kousa Burg. fruit extract as an active ingredient. The Cornus kousa Burg. fruit extract is isolated from Cornus kousa Burg. fruit using alcohol aqueous solution or isolated by double-boiling. The pharmaceutical composition contains Cornus kousa Burg. fruit fraction as an active ingredient. The fraction is obtained using ethyl acetate and H_2O and by extracting H_2O layer using n-butanol. The pharmaceutical composition also contains triterpene compounds from the fraction or pharmaceutically acceptable salt thereof as an active ingredient. The triterpene compounds is ursolic acid of chemical formula 1, corosolic acid of chemical formula 2, taraxasterol of chemical formula 3, betulinic acid of chemical formula 4, or betulinic aldehyde of chemical formula 5.

    Abstract translation: 目的：一种含有萸肉芽孢杆菌的药物组合物。 提供水果提取物以抑制人类酰基辅酶A（hACAT）并预防和治疗心血管疾病。 构成：用于预防和治疗由于高胆固醇血症引起的心血管疾病的药物组合物含有萸肉芽孢杆菌（Cornus kousa Burg）。 水果提取物作为活性成分。 山茱萸Burg。 水果提取物是从Corn a is分离出来的。 水果使用酒精水溶液或通过双沸腾分离。 该药物组合物含有Cornus kousa Burg。 水果部分作为活性成分。 使用乙酸乙酯和H_2O获得级分，并使用正丁醇提取H_2O层。 药物组合物还含有来自该级分或其药学上可接受的盐的三萜化合物作为活性成分。 三萜化合物是化学式1的熊果酸，化学式2的科罗索酸，化学式3的焦ax甾醇，化学式4的桦木酸或化学式5的桦木醛。

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