公开(公告)号：KR101078889B1

公开(公告)日：2011-11-01

申请号：KR1020097022294

申请日：2008-03-24

Applicant: 고려대학교 산학협력단

Inventor： 김재홍 ,  최정아 ,  김은영 ,  김근영 ,  김철민 ,  서지민 ,  김현주 ,  이진욱

IPC: A61K39/395 ,  A61K35/00 ,  A61K31/7105

CPC classification number: C07K16/28 ,  C07K14/705 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315

Abstract: 본발명자들은방광, 전립선, 췌장, 및유방암과같은인간의암의생존인자로써 BLT2의역할을증명하였으며, BLT2 저해제를항-암약물로써사용할수 있음을발견하였다. 본발명자들은 BLT2가암 세포의전이와종양의혈관신생에서중요한역할을함을증명하였으며, BLT2 저해제가암 세포의세포사멸을유도하고, 암세포의전이를억제하고, 또는종양의혈관신생을억제함으로써항-암활성을나타냄을증명하였다.

公开(公告)号：KR1020090125839A

公开(公告)日：2009-12-07

申请号：KR1020097022294

申请日：2008-03-24

Applicant: 고려대학교 산학협력단

Inventor： 김재홍 ,  최정아 ,  김은영 ,  김근영 ,  김철민 ,  서지민 ,  김현주 ,  이진욱

IPC: A61K39/395 ,  A61K35/00 ,  A61K31/7105

CPC classification number: C07K16/28 ,  C07K14/705 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315

Abstract: PURPOSE: An inhibitor of leukotriene B4 receptor BLT2 is provided to suppress of possibility of metastasis of cancer cells and treat cancer such as breast cancer, prostate cancer, and pancreatic cancer. CONSTITUTION: An inhibitor of leukotriene B4 receptor BLT2 for treating human cancer suppresses expression and intracellular signal transduction of BLT2. The inhibitor is LY255283(1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1/-/-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone). Human cancer is tumor in which BLT2 protein or oncogene RAS is overexpressed. A pharmaceutical composition for treating human cancer contains mixture of material which suppresses intracellular signal transduction or BLT2 expression and other anticancer drug as active ingredient.

Abstract translation: 目的：提供白三烯B4受体BLT2的抑制剂，以抑制癌细胞转移的可能性并治疗癌症，如乳腺癌，前列腺癌和胰腺癌。 构成：用于治疗人类癌症的白细胞三烯B4受体BLT2抑制剂抑制BLT2的表达和细胞内信号转导。 抑制剂是LY255283（1- [5-乙基-2-羟基-4 - [[6-甲基-6-（1 / - 四唑-5-基）庚基]氧基]苯基] - 乙酮）。 人类癌症是其中BLT2蛋白或致癌基因RAS过表达的肿瘤。 用于治疗人类癌症的药物组合物含有抑制细胞内信号转导或BLT2表达的物质和其它抗癌药物作为活性成分的混合物。