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    알츠하이머 질병의 진단을 위한 바이오마커
    3.
    发明公开
    알츠하이머 질병의 진단을 위한 바이오마커 审中-实审
    用于诊断阿尔茨海默病的生物标志物

    公开(公告)号：KR1020170127089A

    公开(公告)日：2017-11-21

    申请号：KR1020160056912

    申请日：2016-05-10

    Applicant: 조선대학교산학협력단

    Inventor： 송우근 ,  이건호 ,  이정훈 ,  김소희

    IPC: C12Q1/68 ,  G06F19/18 ,  A61K31/7088

    Abstract: 본발명은알츠하이머성치매를진단하기위한신규한바이오마커를제공하는것에관한것이다. 본발명에따른 miRNA 바이오마커를이용하여비침습적이고간편하며특이도와민감도가높은진단방법을제공할할 수있다. 이와같이, 본발명은정확한알츠하이머성치매진단을가능하게하며, 알츠하이머성치매치료제를개발하는타겟을제공할수 있다.

    Abstract translation: 本发明涉及提供用于诊断阿尔茨海默氏痴呆的新型生物标志物。 通过使用根据本发明的miRNA生物标志物，可以提供非侵入性，简单，特异性和敏感性的诊断方法。 因此，本发明能够准确诊断阿尔茨海默氏痴呆，并且可以提供开发阿尔茨海默氏痴呆治疗剂的目标。

    독성이 제거된 오메가 코노독소 변형체 에피토프 및 단일클론 항체
    4.
    发明公开
    독성이 제거된 오메가 코노독소 변형체 에피토프 및 단일클론 항체 无效
    双重突变体OMEGA CONOTOXIN GVIA疱疹病毒及其单克隆抗体

    公开(公告)号：KR1020030036378A

    公开(公告)日：2003-05-09

    申请号：KR1020030017307

    申请日：2003-03-20

    Applicant: 애니젠 주식회사 ,  광주과학기술원

    Inventor： 김재일 ,  송우근 ,  박영진

    IPC: C07K14/435

    CPC classification number: C07K14/43504 ,  C07K16/18 ,  C07K2317/14 ,  C07K2319/00 ,  C07K2319/40 ,  C12N15/62 ,  C12N15/70

    Abstract: PURPOSE: Double mutant omega conotoxin GVIA epitope and a monoclonal antibody thereof are provided. The double mutant omega conotoxin GVIA epitope can be used for developing a new tagged vector system having the appropriate tagging size of amino acids and improved detection efficiency, so that the detection, isolation and purification of a target protein can be easily carried out. CONSTITUTION: Double mutant omega conotoxin GVIA epitope having no toxicity has the amino acid sequence of SEQ ID NO: 1 and a tertiary structure through a cysteine bond within peptide molecules. cDNA clone for the expression of the double mutant omega conotoxin GVIA epitope has the nucleotide sequence of SEQ ID NO: 2. A tagged vector for the expression of the double mutant omega conotoxin GVIA epitope-tagged protein has the nucleotide sequence of SEQ ID NO: 3. A monoclonal antibody of the double mutant omega conotoxin GVIA epitope-tagged protein is prepared by preparing a hybridoma cell line of a spleen cell and a myeloma cell of a double mutant omega conotoxin-immunized mouse; culturing the hybridoma cell line, followed by Intraperitoneal injection into a mouse; and isolating and purifying a monoclonal antibody of the double mutant omega conotoxin GVIA epitope from the mouse.

    Abstract translation: 目的：提供双重突变体ω-芋螺毒素GVIA表位及其单克隆抗体。 双突变体ω-芋螺毒素GVIA表位可用于开发具有适当的氨基酸标签大小和提高的检测效率的新的标记载体系统，从而可以容易地进行靶蛋白的检测，分离和纯化。 构成：没有毒性的双突变体ω-芋螺毒素GVIA表位具有SEQ ID NO：1的氨基酸序列和通过肽分子内的半胱氨酸键的三级结构。 用于表达双重突变体ω-芋螺毒素GVIA表位的cDNA克隆具有SEQ ID NO：2的核苷酸序列。用于表达双重突变型ω-角毒素GVIA表位标记蛋白的标记载体具有SEQ ID NO： 通过制备双突变体ω-芋头毒素免疫的小鼠的脾细胞和骨髓瘤细胞的杂交瘤细胞系来制备双重突变体ω-芋螺毒素GVIA表位标记蛋白的单克隆抗体; 培养杂交瘤细胞系，然后腹膜内注射入小鼠; 并从小鼠中分离和纯化双重突变体ω-芋螺毒素GVIA表位的单克隆抗体。

    친족점 연결을 이용한 수골 및 손목뼈 영상의 분할방법
    6.
    发明授权
    친족점 연결을 이용한 수골 및 손목뼈 영상의 분할방법 有权
    使用相关点连接的药物和卡片图像分割方法

    公开(公告)号：KR101111676B1

    公开(公告)日：2012-03-05

    申请号：KR1020100102057

    申请日：2010-10-19

    Applicant: 광주과학기술원

    Inventor： 김진영 ,  최승호 ,  당트란부 ,  송우근

    IPC: A61B6/00 ,  G06T9/20

    Abstract: PURPOSE: A segmentation method for the image of phalanges and a carpal using relative point connection are provided to precisely measure a bone age by using a relative point connection method and processing individual bones through an X-ray image. CONSTITUTION: Boundary points from which faults are removed are detected from an inputted image in a preprocess step(S200). The assembly of curves generates curve segment combination in a connection step(S300). A curve which does not satisfy conditions is removed in filtering(S400). A boundary combination of an animal bone and a carpal in combination step(S500). It is determined whether a line is a closed curve is not(S600).

    Abstract translation: 目的：提供使用相对点连接的趾骨图像和腕管的分割方法，以通过使用相对点连接方法精确测量骨龄，并通过X射线图像处理单个骨骼。 构成：在预处理步骤中从输入图像中检测到从中去除故障的边界点（S200）。 曲线组合在连接步骤中生成曲线段组合（S300）。 在过滤中除去不满足条件的曲线（S400）。 组合步骤中的动物骨和腕管的边界组合（S500）。 确定线是否为闭合曲线不是（S600）。

    Ｅ-실렉틴 면역어드헤신
    7.
    发明授权
    Ｅ-실렉틴 면역어드헤신 有权
    -Selectin免疫粘附素

    公开(公告)号：KR100812260B1

    公开(公告)日：2008-03-10

    申请号：KR1020060055320

    申请日：2006-06-20

    Applicant: 광주과학기술원

    Inventor： 송우근 ,  성봉환 ,  김진규

    IPC: C07K19/00

    Abstract: 본 발명은 (a) E-실렉틴(E-selectin), (b) 면역글로블린 G(IgG)의 힌지 및 (c) IgG의 Fc 도메인이 순차적으로 결합된 E-실렉틴 면역어드헤신(immunoadhesin), 이를 코딩하는 핵산 분자 및 이를 포함하는 항염증 약제학적 조성물에 관한 것이다. 본 발명에 따르면, 본 발명의 E-실렉틴 면역어드헤신에서, E-실렉틴 부분은 백혈구 롤링을 비염증 수준으로 크게 감소시킴으로써, 백혈구가 사이토카인-자극된 내피세포에 결합하는 것을 억제하며, 결국 염증성 반응을 크게 감소시키는 작용을 한다. 또한, 본 발명의 E-실렉틴 면역어드헤신에서 IgG 힌지 및 Fc 도메인은 본 발명의 면역어드헤신의 체내 안정성을 크게 증가시키는 작용을 한다. 따라서 본 발명의 E-실렉틴 면역어드헤신은 항염증제로서 우수한 효능을 발휘한다.
    E-실렉틴, 면역어드헤신, 백혈구, IgG, 내피세포

    Ｅ-실렉틴 면역어드헤신
    8.
    发明公开
    Ｅ-실렉틴 면역어드헤신 有权
    E-SELECTIN IMMUNOADHESIN

    公开(公告)号：KR1020070120716A

    公开(公告)日：2007-12-26

    申请号：KR1020060055320

    申请日：2006-06-20

    Applicant: 광주과학기술원

    Inventor： 송우근 ,  성봉환 ,  김진규

    IPC: C07K19/00

    CPC classification number: C07K14/70564 ,  A61K38/178 ,  C07K16/00 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2319/30

    Abstract: An E-selectin immunoadhesin is provided to decrease an inflammatory reaction significantly by inhibiting a binding of leukocyte to a cytokine-stimulated endothelial cell due to an E-selectin portion and increase the in vivo stability of the immunoadhesin due to an IgG hinge and an Fc domain. An E-selectin immunoadhesin is characterized in that an E-selectin, a hinge of immunoglobulin G(IgG) and an Fc domain of the IgG are linked in sequence, wherein the E-selectin is an extracellular region of the E-selectin, and the IgG is IgG1. A nucleic acid molecule includes a nucleotide sequence encoding the E-selectin immunoadhesin, which is described in SEQ ID : NO. 5. A anti-inflammatory pharmaceutical composition comprises a pharmaceutically effective amount of the E-selectin immunoadhesin and a pharmaceutically acceptable carrier.

    Abstract translation: 提供E-选择素免疫粘附素，通过抑制由于E-选择蛋白部分而导致的白细胞与细胞因子刺激的内皮细胞的结合，并且由于IgG铰链和Fc增加免疫粘附素的体内稳定性而显着降低炎症反应 域。 E-选择蛋白免疫粘附素的特征在于E-选择素，免疫球蛋白G（IgG）的铰链和IgG的Fc结构域依次连接，其中E-选择素是E-选择蛋白的胞外区，以及 IgG是IgG1。 核酸分子包括编码E-选择蛋白免疫粘附素的核苷酸序列，其描述于SEQ ID NO： 抗炎药物组合物包含药学有效量的E-选择蛋白免疫粘附素和药学上可接受的载体。

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