公开(公告)号：KR101071305B1

公开(公告)日：2011-10-07

申请号：KR1020080098737

申请日：2008-10-08

Applicant: 국립암센터

Inventor： 노승배 ,  박상윤

IPC: A61K38/16 ,  A61P29/00 ,  A61P35/00

CPC classification number: A61K38/1709 ,  Y02A50/463

Abstract: 본발명은 ARH1 단백질또는이를코딩하는유전자의신규한용도에관한것으로, 더욱상세하게는 ARH1 단백질또는이를코딩하는유전자를유효성분으로포함하는 NF-&kgr;B 억제제, 상기억제제를함유하는혈관신생관련질환, 염증성질환, 자가면역질환또는바이러스성질환치료용조성물에관한것이다.

公开(公告)号：KR1020100039676A

公开(公告)日：2010-04-16

申请号：KR1020080098737

申请日：2008-10-08

Applicant: 국립암센터

Inventor： 노승배 ,  박상윤

IPC: A61K38/16 ,  A61P29/00 ,  A61P35/00

CPC classification number: A61K38/1709 ,  Y02A50/463

Abstract: PURPOSE: An NF-kappaB inhibitor containing ARH1 protein or gene encoding the same is provided to suppress intracellular NF-kappa B and treat inflammatory disease, autoimmune diseases, or viral diseases. CONSTITUTION: A NF-kappa B inhibitor contains an ARH1 protein or gene encoding the same as an active ingredient. The ARH1 protein suppresses nuclear translocation of p50 or p65 of NF-kappaB. The NF-kappaB inhibitor is performed by binding ARH1 protein and TRADD(TNF receptor-associated death domain). The ARH1 protein or a gene encoding the same is derived from human. A composition for treating disease relating to NF-kappa abnormal activation contains the NF-kappaB inhibitor.

Abstract translation: 目的：提供含有ARH1蛋白或编码该基因的基因的NF-κB抑制剂以抑制细胞内NF-κB并治疗炎性疾病，自身免疫性疾病或病毒性疾病。 构成：NF-κB抑制剂含有编码与活性成分相同的ARH1蛋白或基因。 ARH1蛋白抑制NF-κBp50或p65的核易位。 NF-κB抑制剂通过结合ARH1蛋白和TRADD（TNF受体相关的死亡域）进行。 ARH1蛋白或编码该基因的基因来源于人。 用于治疗与NF-κB异常活化有关的疾病的组合物含有NF-κB抑制剂。