公开(公告)号：KR1020110046987A

公开(公告)日：2011-05-06

申请号：KR1020090103723

申请日：2009-10-29

Applicant: 국립암센터

Inventor： 이연수 ,  고성호 ,  홍성혜 ,  김인후 ,  정진숙

IPC: C12Q1/68 ,  C12N15/11 ,  G01N33/574 ,  A61K39/395

CPC classification number: G01N33/57415 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/5743 ,  A61K39/395

Abstract: PURPOSE: A composition containing an agent for measuring eIF3m expression level is provided to diagnose cancer with high diagnosis sensitivity and specificity. CONSTITUTION: A composition for detecting cancer marker contains an agent for measuring eIF3m mRNA or protein expression level. The agent for measuring mRNA expression level is a primer pair, probe, or antisense nucleotide. The agent for measuring protein expression level is an antibody. A kit for diagnosing cancer contains the composition. A composition for preventing and treating cancer contains an oligonucleotide which suppresses eIF3m polynucleotide expression.

Abstract translation: 目的：提供含有用于测量eIF3m表达水平的试剂的组合物，用于诊断具有高诊断敏感性和特异性的癌症。 构成：用于检测癌症标志物的组合物含有用于测量eIF3m mRNA或蛋白质表达水平的试剂。 用于测量mRNA表达水平的试剂是引物对，探针或反义核苷酸。 用于测量蛋白质表达水平的试剂是抗体。 用于诊断癌症的试剂盒包含组合物。 用于预防和治疗癌症的组合物含有抑制eIF3m多核苷酸表达的寡核苷酸。

公开(公告)号：KR101133243B1

公开(公告)日：2012-04-06

申请号：KR1020090103723

申请日：2009-10-29

Applicant: 국립암센터

Inventor： 이연수 ,  고성호 ,  홍성혜 ,  김인후 ,  정진숙

IPC: C12Q1/68 ,  C12N15/11 ,  G01N33/574 ,  A61K39/395

CPC classification number: G01N33/57415 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/5743

Abstract: Disclosed are a cancer marker-detecting composition comprising an agent for measuring an mRNA or protein expression level of eIF3m, a cancer diagnosis kit comprising the same, a method for detecting an eIF3m polynucleotide or protein by treating a biological specimen with the agent to detect a substance binding specifically to the agent and quantitatively comparing the substance between a subject and a normal control, and a method for the treatment and prevention of cancer comprising an agent for down-regulating the expression of an eIF3m polynucleotide or protein.