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公开(公告)号：KR1020150050523A
公开(公告)日：2015-05-08
申请号：KR1020147031005
申请日：2013-04-04
Applicant: 그로브 인스트루먼츠 인코퍼레이티드
CPC classification number: A61B5/14532 , A61B5/0051 , A61B5/1455 , A61B5/6816 , A61B5/6826 , A61B2560/0431 , A61B2562/0233 , A61B2562/146 , F04C2270/041 , G01N21/1717 , G01N21/314 , G01N21/359 , G01N21/474 , G01N21/49 , G01N33/49 , G01N2021/3148 , G01N2021/4709 , G01N2021/475 , G01N2201/0221 , G01N2201/0631 , G01N2201/0636
Abstract: 파이버리스트랜스플렉턴스프로브(20)를이용하여샘플매트릭스(22) 중의타겟분석물의농도를비침습적으로측정하는방법및 장치가개시된다. 이러한방법및 장치는상이한파장의적어도 2개의성분으로이루어지는전자기복사선의빔을샘플매트릭스(22)로지향시키고, 후방산란된복사선을샘플매트릭스(22)에서 2개의파장의차등흡수율을나타내는신호를출력하는검출기(18)로안내하는것을포함한다. 트랜스플렉턴스프로브(20)는내부반사면(52)을갖는테이퍼진관형하우징(50), 외부반사면(45)을갖는광학로드(40), 및프로브와샘플매트릭스(22)의표면사이에서인터페이스의역할을하는검출윈도우(46)를포함한다. 설명된방법및 장치는혈액을포함하는조직(22)에서혈당의농도를측정하는데에특히유용하다.
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公开(公告)号：KR101597310B1
公开(公告)日：2016-02-24
申请号：KR1020097008408
申请日：2007-09-10
Applicant: 그로브 인스트루먼츠 인코퍼레이티드
IPC: A61B5/00 , G01N21/31 , A61B5/1455
CPC classification number: G01N21/3151 , A61B5/14532 , A61B5/1455 , G01N21/35 , G01N21/49
Abstract: 샘플을통해흐르는유체내에용해된대상분석물의농도를비침습적으로측정하는개선된방법이제공된다. 이방법은다른파장들의시간다중화된성분으로이루어진, 전자기방사의프로브빔을샘플을통해지향시키는단계로서, 시간다중화된성분들중 적어도하나는 2개의다른동시적파장으로이루어지고, 그강도관계는그들결합의유효파장을규정하는상기단계, 및서로다른샘플상태들에서, 상기시간다중화된성분들의방사흡수의차를측정하는단계를포함한다. 샘플상태의변화동안, 샘플내에서대상분석물을담고있는유체의양은변화하고, 이것은샘플의흡수특성뿐만아니라샘플내의대상분석물의총량을변화시킨다. 샘플상태는, 예를들어, 조직샘플을압축하고비압축함으로써생성된다. 제시된방법의정확성은, 샘플내에서대상분석물을포함하는유체의양을연속적으로예측하고, 대상분석물이상당히흡수하는파장에서의흡수율변동을측정하는것을포함함으로써향상된다. 본발명은혈액을포함하는조직내에서글루코오스와같은대상분석물의농도를측정하는데특히유용하다. 본방법을수행하는장치도또한개시된다.
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公开(公告)号：KR1020090086202A
公开(公告)日：2009-08-11
申请号：KR1020097008408
申请日：2007-09-10
Applicant: 그로브 인스트루먼츠 인코퍼레이티드
IPC: A61B5/00 , G01N21/31 , A61B5/1455
CPC classification number: G01N21/3151 , A61B5/14532 , A61B5/1455 , G01N21/35 , G01N21/49
Abstract: An improved method for non-invasively measuring a concentration of a target analyte dissolved in a fluid flowing through a sample is presented. It includes directing a probe beam of electromagnetic radiation, consisting of time multiplexed components of different wavelengths, where at least one of the time-multiplexed components consists of two different simultaneous wavelengths, whose intensity relation defines the effective wavelength of their combination, through the sample and measuring the difference of the absorption of the radiation of the time-multiplexed components at different sample states. During sample state changes, the amount of fluid containing the target analyte within the sample is changing, which varies the total amount of target analyte in the sample, as well as the absorption properties of the sample. The sample states are produced, for instance, by compressing and uncompressing the tissue sample. The accuracy of the presented method is enhanced. by including continuous estimation of the amount of the fluid containing the target analyte within the sample, and measurement of the variations of the absorption at a wavelength at which the target analyte absorbs significantly. The method is particularly useful in measuring the concentration of a target analyte, such as glucose, in tissue containing blood. An apparatus for performing this method also is disclosed. ® KIPO & WIPO 2009
Abstract translation: 提出了一种用于非侵入性地测量溶解在流过样品的流体中的目标分析物的浓度的改进方法。 它包括引导由不同波长的时间复用分量组成的电磁辐射探测光束，其中时间复用分量中的至少一个由强度关系定义其组合的有效波长的两个不同的同时波长组成，通过样本 并且测量不同样本状态下的时分复用分量的辐射吸收的差异。 在样品状态变化期间，样品内含有目标分析物的流体量发生变化，这样会改变样品中目标分析物的总量以及样品的吸收性能。 样品状态例如通过压缩和解压缩组织样品而产生。 提出的方法的准确性得到提高。 通过包括对样品中含有目标分析物的流体的量的连续估计，以及在目标分析物显着吸收的波长处的吸收变化的测量。 该方法特别可用于在含有血液的组织中测量目标分析物（例如葡萄糖）的浓度。 还公开了一种用于执行该方法的装置。 ®KIPO＆WIPO 2009
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