公开(公告)号：KR101070964B1

公开(公告)日：2011-10-06

申请号：KR1020090000633

申请日：2009-01-06

Applicant: 대구한의대학교산학협력단

Inventor： 김광중 ,  양재하 ,  장은영 ,  곽재일

IPC: A61K36/233 ,  A61P25/30

Abstract: 본발명은시호추출물을유효성분으로함유하는조성물에관한것으로서, 구체적으로본 발명의시호추출물은반복적인니코틴투여로인한민감화유발동물모델에서약물중독의지표로사용되는행동적민감화(Behavioral sensitization) 반응인보행성활동량및 상동적행동량의감소효과뿐만아니라, 뇌의측핵과선조체에서의신경활성지표인 c-Fos 및 FosB 발현을급격히감소시킴을확인함으로써, 상기조성물은약물중독및 금단증상의예방및 치료를위한약학조성물또는건강기능식품으로유용하게이용될수 있다.

公开(公告)号：KR1020100081405A

公开(公告)日：2010-07-15

申请号：KR1020090000633

申请日：2009-01-06

Applicant: 대구한의대학교산학협력단

Inventor： 김광중 ,  양재하 ,  장은영 ,  곽재일

IPC: A61K36/233 ,  A61P25/30

Abstract: PURPOSE: A composition containing Bupleurum falcatum L. extract is provided to reduce activity amount and c-Fos and FosB expression and to prevent and treat drug addiction and withdrawal symptom. CONSTITUTION: A pharmaceutical composition for preventing and treating drug addiction and withdrawal symptom contains 0.02-50 weight% of Bupleurum falcatum L. extract as an active ingredient. The extract is soluble extract in water, low alcohol of C1-C4, or mixture solvent thereof. A health food for preventing and treating drug addiction and withdrawal symptom contains Bupleurum falcatum L. extract as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, syrup, or beverage.

Abstract translation: 目的：提供含有柴胡提取物的组合物，以减少活性量和c-Fos和FosB表达，并预防和治疗药物成瘾和戒断症状。 构成：用于预防和治疗药物成瘾和戒断症状的药物组合物含有0.02-50重量％的柴胡提取物作为活性成分。 提取物是水中的可溶性提取物，C1-C4的低级醇或其混合溶剂。 用于预防和治疗药物成瘾和戒断症状的保健食品含有柴胡提取物作为活性成分。 保健食品以粉末，颗粒，片剂，胶囊，糖浆或饮料的形式使用。