公开(公告)号：KR1020160092657A

公开(公告)日：2016-08-05

申请号：KR1020150013306

申请日：2015-01-28

Applicant: 대구한의대학교산학협력단

Inventor： 김용웅 ,  민유홍 ,  박문기 ,  박찬익 ,  양재하

IPC: A61K36/534 ,  A61K31/045

CPC classification number: A61K36/534 ,  A61K31/045

Abstract: 본발명은테스토스테론 5α-환원효소저해제(testosterone 5α-reductase inhibitor)에관한것으로, 더욱상세하게는박하유(peppermint oil) 성분을유효성분으로하는양성전립선비대증치료또는예방용약학적조성물에관한것이다. 상기와같은본 발명은박하유(peppermint oil) 성분을유효성분으로함유하는양성전립선비대증치료또는예방용약학적조성물인것을특징으로한다. 이때상기박하유(peppermint oil) 성분은 (-)-멘톨((-)-menthol), (+)-멘톨((+)-menthol), (-)-아세트산멘틸((-)-menthyl acetate), 풀레곤(pulegone) 중의어느하나인것을특징으로한다.

Abstract translation: 本发明涉及睾酮5-还原酶抑制剂。 更具体地说，本发明涉及一种用于治疗或预防良性前列腺增生的药物组合物，其包含薄荷油成分作为活性成分。 本发明提供一种用于治疗或预防良性前列腺增生的药物组合物，其包含薄荷油成分作为活性成分。 薄荷油成分是（ - ） - 薄荷醇，（+） - 薄荷醇，（ - ） - 乙酸薄荷酯和胡椒粉中的任何一种。

公开(公告)号：KR1020130073040A

公开(公告)日：2013-07-03

申请号：KR1020110140677

申请日：2011-12-23

Applicant: 대구한의대학교산학협력단

Inventor： 박문기 ,  이종록 ,  정대화 ,  문외숙

IPC: A61K31/343 ,  A61K31/34 ,  A61K8/97 ,  A61P17/00

Abstract: PURPOSE: A compound isolated from a Hemistepita lyrata Bunge extract, and a composition containing the same for preventing and treating dandruff are provided to strongly suppress M. obtuse, and to be used as an external use skin pharmaceutical composition or a cosmetic composition for preventing and treating dandruff. CONSTITUTION: A pharmaceutical composition for preventing and treating dandruff contains hemistepsin A, hemistepsin B, or a pharmaceutically acceptable salt thereof isolated from a Hemistepita lyrata Bunge extract as an active ingredient. The pharmaceutical composition is a cream, a gel, a patch, a spray, an ointment, a lotion, a liniment, a paste, or a cataplasma formulation. A cosmetic composition for preventing and treating dandruff contains hemistepsin A, hemistepsin B, or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract translation: 目的：提供从Hemistepita lyrata Bunge提取物中分离出的化合物和含有该化合物以防止和治疗头皮屑的组合物，以强烈抑制M.blutuse，并用作外用皮肤药物组合物或用于预防和治疗头皮屑的化妆品组合物 治疗头皮屑 构成：用于预防和治疗头皮屑的药物组合物含有作为活性成分从Hemistepita lyrata Bunge提取物中分离的半溶血素A，半抗抑郁素B或其药学上可接受的盐。 药物组合物是乳膏，凝胶，贴剂，喷雾剂，软膏，洗剂，搽剂，糊剂或粘膜制剂。 用于预防和治疗头皮屑的化妆品组合物含有半溶蛋白A，半溶血蛋白B或其药学上可接受的盐作为活性成分。

公开(公告)号：KR1020130033631A

公开(公告)日：2013-04-04

申请号：KR1020110097401

申请日：2011-09-27

Applicant: 대구한의대학교산학협력단

Inventor： 박문기 ,  이종록 ,  정대화 ,  문외숙

IPC: A61K36/605 ,  A61K36/14 ,  A61K36/232 ,  A61K36/804 ,  A61K8/97 ,  A61Q7/00

CPC classification number: A61K36/605 ,  A61K8/97 ,  A61K36/14 ,  A61K36/232 ,  A61K36/804 ,  A61K2800/74 ,  A61Q7/00

Abstract: PURPOSE: An external use composition containing a complex crude drug extract containing cypress phytoncide is provided to suppress dandruff without side effects or toxicity. CONSTITUTION: A pharmaceutical composition for external use for preventing alopecia, suppressing dandruff, and promoting hair growth contains a complex crude drug extract containing ginger, mulberry, Rehmannia glutinosa var. purpurea, Angalica gigas Nakai, and cypress phytoncide as an active ingredient. The extract is prepared using water including purified water, C1-C4 alcohol, or a mixture thereof. [Reference numerals] (AA) Control group; (BB) 8-th group;

Abstract translation: 目的：提供含有柏油植物苷的复合生物药物提取物的外用组合物，以抑制头屑，无副作用或毒性。 构成：用于预防脱发，抑制头皮屑和促进头发生长的外用药物组合物含有含有姜，桑，地黄变种的复合生药提取物。 紫草，黑加仑，桧属植物激素等作为活性成分。 提取物使用包括净化水，C1-C4醇或其混合物的水制备。 （附图标记）（AA）对照组; （BB）第8组;

公开(公告)号：KR1020130033624A

公开(公告)日：2013-04-04

申请号：KR1020110097386

申请日：2011-09-27

Applicant: 대구한의대학교산학협력단

Inventor： 박문기 ,  이종록 ,  정대화 ,  이양수

IPC: A61K36/27 ,  A61K36/605 ,  A61K36/234 ,  A61K36/804 ,  A61K8/97 ,  A61Q7/00

CPC classification number: A61K36/27 ,  A61K8/97 ,  A61K36/234 ,  A61K36/605 ,  A61K36/804 ,  A61K2800/74 ,  A61Q7/00

Abstract: PURPOSE: An external use composition containing a complex crude drug extract which prevents alopecia and promotes hair growth is provided to suppress dandruff without causing side effects or toxicity. CONSTITUTION: An external use composition which prevents alopecia and promotes hair growth contains a complex crude drug extract as an active ingredient. The complex crude drug extract includes Morus alba leaves, mulberry, Pleuropterus multflorus, Ligusticum wallichiii Franch, Chrysanthemum lavandulifolum, and Rehmannia glutinosa var. purpurea. The extract is prepared using water including purified water, alcohol, C1-C4 alcohol, or a mixture thereof. [Reference numerals] (AA) Control group; (BB) 6-th group;

Abstract translation: 目的：提供含有防止脱发并促进头发生长的复合生药提取物的外用组合物，以抑制头皮屑而不引起副作用或毒性。 构成：防止脱发并促进毛发生长的外用组合物含有复合生药提取物作为活性成分。 复合生物药物提取物包括桑ba，桑，，茯苓，枸杞，菊苣和地黄。 菊。 提取物使用包括纯化水，醇，C 1 -C 4醇或其混合物的水制备。 （附图标记）（AA）对照组; （BB）第6组;

公开(公告)号：KR102208665B1

公开(公告)日：2021-01-28

申请号：KR1020190039450

申请日：2019-04-04

Applicant: 대구한의대학교산학협력단

Inventor： 홍금표 ,  이종록 ,  박문기 ,  정대화 ,  장미희 ,  최덕호

IPC: A61K36/734 ,  A61P21/00 ,  A23L33/105

Abstract: 본발명은산사추출물을유효성분으로포함하는근육질환의예방, 치료또는개선용조성물에관한것으로, 본발명의산사추출물은마이오스타틴의발현량감소또는젖산의축적을억제하는효과가우수하여, 이를근육질환의치료제또는건강기능식품으로유용하게사용할수 있다.

公开(公告)号：KR101740970B1

公开(公告)日：2017-05-30

申请号：KR1020110097401

申请日：2011-09-27

Applicant: 대구한의대학교산학협력단

Inventor： 박문기 ,  이종록 ,  정대화 ,  문외숙

IPC: A61K36/605 ,  A61K36/14 ,  A61K36/232 ,  A61K36/804 ,  A61K8/97 ,  A61Q7/00

Abstract: 본발명은편백나무피톤치드를첨가한복합생약추출물(D)의탈모방지및 발모촉진효과를갖는외용조성물에관한것으로서, 더욱상세하게는생강, 오디, 생지황, 당귀의조합생약추출물에편백나무피톤치드를첨가하여마우스를이용한실험에서모발생장효과를나타내는바, 탈모방지및 발모촉진효과를갖는피부외용약학조성물및 화장료조성물에유용하게사용가능하다.

Abstract translation: 本发明涉及一种用于具有防止毛发损失和头发生长促进添加柏树植物杀菌素，并且更具体地，柏树植物杀菌素生姜，桑树，saengjihwang组合草药提取物（d）的效果的外用组合物，组合当归的草药提取物 条表示在使用鼠标的实验中的毛发生长效果，该混合物可以是用于皮肤外用的药物组合物和具有防止毛发损失和毛发生长促进效果的化妆品组合物是有用的。

公开(公告)号：KR1020120059825A

公开(公告)日：2012-06-11

申请号：KR1020100121291

申请日：2010-12-01

Applicant: 대구한의대학교산학협력단

Inventor： 박종필 ,  박문기

IPC: C12P7/06 ,  C12P7/16 ,  C12P7/22 ,  C12N1/14

CPC classification number: Y02E50/17 ,  C12P7/04 ,  C12P7/24 ,  C12P7/26 ,  C12P7/28 ,  C12P7/62 ,  C12P17/02

Abstract: PURPOSE: A method for producing natural flavoring agent through extracellular liquid culture for Leatiporus sulphureus var. miniatus mycelium is provided to contain various types of flavoring agent. CONSTITUTION: A method for producing natural flavoring agent comprises a step of extracellular liquid culture for Leatiporus sulphureus var. miniatus mycelium. A medium for producing the natural flavoring agent contains 3 wt% of soluble starch, 0.5 wt% of yeast extract, 0.2 wt% of polypeptone, 0.1 wt% of K_2HPO_4, and 0.01wt% of MgSO_4,7H_2O. The natural flavoring agent belongs to alcohols, aldehydes or esters. The alcohols include ethyl alcohol, isobutyl alcohol, butanol, 2-methyl butanol, isoamyl alcohol, 4-phentyl alcohol, hexanol, 3-octanol, 2-ethyl hexanol, furfuryl alcohol or 3-phenyl propyl alcohol.

Abstract translation: 目的：通过细胞外液体培养生产天然调味剂的方法，用于雷氏硫杆菌（Leatiporus sulphureus var。 提供微型菌丝体以容纳各种类型的调味剂。 构成：一种生产天然调味剂的方法，包括硫酸雷帕氏菌的细胞外液体培养步骤。 迷你菌丝体 用于生产天然调味剂的介质含有3重量％的可溶性淀粉，0.5重量％的酵母提取物，0.2重量％的聚胨，0.1重量％的K_2HPO_4和0.01重量％的MgSO 4·4H 2 O。 天然调味剂属于醇类，醛类或酯类。 醇包括乙醇，异丁醇，丁醇，2-甲基丁醇，异戊醇，4-正庚醇，己醇，3-辛醇，2-乙基己醇，糠醇或3-苯基丙醇。

公开(公告)号：KR1020130033623A

公开(公告)日：2013-04-04

申请号：KR1020110097385

申请日：2011-09-27

Applicant: 대구한의대학교산학협력단

Inventor： 박문기 ,  이종록 ,  정대화 ,  이양수

IPC: A61K36/605 ,  A61K36/65 ,  A61K36/258 ,  A61K8/97 ,  A61Q7/00

CPC classification number: A61K36/605 ,  A61K8/97 ,  A61K36/258 ,  A61K36/65 ,  A61K2800/74 ,  A61Q7/00

Abstract: PURPOSE: An external use composition containing a complex crude drug extract including persimmon leaves is provided to prevent alopecia and to promoting hair growth without side effects and toxicity. CONSTITUTION: A pharmaceutical composition for external use for preventing alopecia, suppressing dandruff, and promoting hair growth contains a Morus alba leaf extract or a complex crude drug extract including mulberry leaves, Paeonia japonica Miyabe and Takeda, Diospyros kaki Thunberg calyx, ginkofolium, ginseng, cnidium, and mulberry as an active ingredient. The extract is prepared using water including purified water, spirit, C1-C4 alcohol, or a mixture solvent thereof. [Reference numerals] (AA) Control group; (BB) 3-rd group;

Abstract translation: 目的：提供含有柿子叶的复合生物药物提取物的外用组合物，以防止脱发和促进头发生长而无副作用和毒性。 构成：用于预防脱发，抑制头皮屑和促进头发生长的外用药物组合物含有桑叶提取物或包括桑叶，芍药P e和武田，柿子aki蓉，银杏，人参， cnidium和桑树作为活性成分。 提取物使用纯水，精油，C1-C4醇或其混合溶剂的水制备。 （附图标记）（AA）对照组; （BB）3组;

公开(公告)号：KR1020100123123A

公开(公告)日：2010-11-24

申请号：KR1020090042163

申请日：2009-05-14

Applicant: 대구한의대학교산학협력단 ,  주식회사 한방명가

Inventor： 박문기

IPC: A61K8/97 ,  A61Q7/00

CPC classification number: A61K8/97 ,  A61K36/00 ,  A61K36/258 ,  A61K36/804 ,  A61K2236/33 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q7/00 ,  Y10S514/88

Abstract: PURPOSE: A composition containing complex herb extract is provided to prevent hair loss and to promote hair growth without side effects of toxicity. CONSTITUTION: A cosmetic composition having effects of preventing hair loss and promoting hair growth contains 0.1-50 weight% of rehmanniae Radix crudus, ginseng Radix rubra, polygoni multiflori Radix, and zingiberis Rhizoma crudus extract as an active ingredient. The extract is isolated using water including purified water, low alcohol of 1-4 carbon atoms, or mixture solvent thereof.

Abstract translation: 目的：提供含有复杂草本提取物的组合物，以防止脱发并促进毛发生长而无毒副作用。 构成：具有防止脱发和促进头发生长的作用的化妆品组合物含有地黄百里香，人参蓝，多鞭草和姜黄提取物为0.1-50重量％的活性成分。 使用纯净水，1-4个碳原子的低级醇或其混合溶剂的水分离提取物。

公开(公告)号：KR1020100110407A

公开(公告)日：2010-10-13

申请号：KR1020090028719

申请日：2009-04-03

Applicant: 대구한의대학교산학협력단

Inventor： 박문기

IPC: A61K8/97 ,  A61Q7/00 ,  A61K36/234 ,  A61P17/14

CPC classification number: A61K8/97 ,  A61K36/00 ,  A61K36/234 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q19/00 ,  Y10S514/88 ,  Y10S514/881

Abstract: PURPOSE: A composition with an effect of preventing hair loss and promoting hair growth without side effects or toxicity is provided. CONSTITUTION: A cosmetic composition with effects of preventing hair loss and promoting hair growth contains Chrysanthemum morifolium, swertia japonica, cnidii Rhizoma, calamus, polygoni multiflori Radix, and fed wild ginseng as an active ingredient. The extract is obtained using water including purified water, spirit, low alcohol of C1-C4, or mixture thereof. An external use pharmaceutical composition with effects of preventing hair loss and promoting hair growth contains mixed herb extract of Chrysanthemum morifolium and swertia japonica, cnidii Rhizoma, calamus, polygoni multiflori Radix, and fed wild ginseng as an active ingredient. The pharmaceutical composition is used in the form of cream, gel, patch, spray, ointment, lotion, liniment, paste, or cataplasma.

Abstract translation: 目的：提供具有防止脱发和促进毛发生长而没有副作用或毒性的作用的组合物。 构成：具有防止脱发和促进毛发生长的作用的化妆品组合物含有菊花，枸杞，枸杞，菖蒲，多芫荽和加入野山参作为活性成分。 提取物是使用纯净水，精油，C1-C4低级醇或其混合物的水得到的。 具有防止脱发和促进头发生长的作用的外用药物组合物含有菊花和枸杞混合草药提取物，枸杞，菖蒲，多花椒，加入野参作为活性成分。 药物组合物以霜剂，凝胶剂，贴剂，喷雾剂，软膏剂，洗剂，搽剂，糊剂或粘膜剂的形式使用。