公开(公告)号：KR1020010016848A

公开(公告)日：2001-03-05

申请号：KR1019990032025

申请日：1999-08-04

Applicant: 대한민국(농촌진흥청장)

Inventor： 김정봉 ,  김종범 ,  조강진 ,  황영수 ,  박노동

IPC: C07C69/732

Abstract: PURPOSE: Provided is a process for separating rosmarinic acid from Agastache rugosa in high purity, wherein the rosmarinic acid is used for producing antioxidizing material and used as additives in food or medical supplies. CONSTITUTION: The process comprises the steps of: drying the Agastache rugosa to have a water content of less than 6 wt. and then pulverizing; adding 2-6 times water, based on the weight of the pulverized Agastache rugosa, to obtain the extracted solution of the Agastache rugosa; filtering the extracted solution, performing an adsorption chromatography and then collecting and condensing activated fractions to obtain the concentrated solution of the rosmarinic acid; performing a gel chromatography of the concentrated solution and drying fractions containing the rosmarinic acid.

Abstract translation: 目的：提供高纯度的迷迭香酸与藿香粗分离的方法，其中迷迭香酸用于生产抗氧化材料，并用作食品或医疗用品中的添加剂。 构成：该方法包括以下步骤：将藿香干燥至含水量小于6wt。 然后粉碎; 加入2-6倍水，根据粉碎的藿香的重量，得到藿香提取液; 过滤提取的溶液，进行吸附色谱，然后收集和浓缩活化的级分，得到迷迭香酸的浓缩溶液; 对浓缩溶液和含有迷迭香酸的干燥级分进行凝胶层析。

公开(公告)号：KR100341798B1

公开(公告)日：2002-06-26

申请号：KR1019990032025

申请日：1999-08-04

Applicant: 대한민국(농촌진흥청장)

Inventor： 김정봉 ,  김종범 ,  조강진 ,  황영수 ,  박노동

IPC: C07C69/732

Abstract: 본발명은방아잎(, giant hyssop)을음건또는동결건조시키고분쇄한분말로부터추출액을수득하여이를여과시키고, 흡착크로마토그래피및 겔크로마토그래피를실시하는공정을포함하는로즈마린산을분리하는방법에관한것이다. 본발명의로즈마린산분리방법은방아잎을건조시키고분쇄하는공정; 분쇄된방아잎중량에대하여 2배내지 6배의물을가하고추출하여, 방아잎추출액을수득하는공정; 추출액을여과하고흡착크로마토그래피를실시한다음, 활성분획을농축시켜로즈마린산농축액을수득하는공정; 및, 전기농축액으로겔 크로마토그래피를실시하고, 로즈마린산을함유한분획을건조시켜고순도의로즈마린산을분리하는공정을포함한다. 본발명에의하면, 로즈마린산의손실을효과적으로줄이면서, 간단한공정에의하여고순도로즈마린산을분리할수 있다. 따라서, 본발명이로즈마린산을유효성분으로하는항산화물질을개발하는데효과적으로기여할수 있는바, 로즈마린산을식품이나의약품의첨가물로이용하는등 로즈마린산의산업적활용도를높일수 있다.