Abstract:
본 발명은 표피 세포 분화 및/또는 증식의 불균형과 연관되는 피부 및/또는 그것의 외피의 심미적 결함의 치료 및/또는 예방용 활성제로서의, 제 1 및 제 2 파트너 단백질 사이의, 또는 상기 단백질의 상동체, 돌연변이체 또는 조각 사이의 상호작용을 조정하는데 적합한 화합물의 용도로서, 상기 제 1 및 제 2 단백질은 SASPase 및 필라그린-2, 또는 FLG2 인 용도에 관한 것이다.
Abstract:
The invention concerns a care or make-up composition for the hair or the eyelashes, containing a heterocyclic compound of formula (I) or one of its salts, wherein: Hy is a heterocycle of 4 to 7 atoms optionally comprising a carbonyl function and/or a thiocarbonyl function, and optionally substituted by at least one substitutent selected among a halogen, OR, SR, NRR', COR, CSR, NRCONR'R", C(=NR)R', C(=NR)NR'R", NRC(=NR')NR"R", OCOR, COSR, SCOR, CSNRR', NRCSR', NRCSNR'R", COOR, CONRR', CF3, CN, NRCOR', SO2R', SO2NRR', NRSO2R', the C1-C20 alkyl radicals saturated or unsaturated, the saturated or unsaturated cycles, optionally containing a heteroatom, said cycles may be separated or fused, the alkyl radicals and the cycles may further be substituted, wherein, wherein R, R', R" and R"', represent a hydrogen, a C1C20 alkyl radical or an aryl radical, optionally substituted; G represents O, S, NH; R1, R2 and R3 represent a hydrogen, a halogen, OR0, SR0, NR0R0, COR0, CSR0, NR0CONR0 R0", C(=NR0) R0, C(=NR0)NR0 R0", NR0 C(=NR0)NR0''R0" OCOR0, COSR0, SCOR0, CSNR0R0', NR0CSR0, NR0CSNR0 R0", COOR0, CONR0R0, CF3, NO2, CN, NR0COR'0, SO2R'0, SO2 NR0R'0, NR0SO2R'0, a C 1,-C20 alkyl radical, saturated or unsaturated, at least one saturated or unsaturated cycle containing optionally a heteroatom, the cycles may be separated or fused, the alkyl radicals may further be substituted, wherein R0, R0, R0" and R 0"', represent a hydrogen, a C1-C20 alkyl or an aryl radical, optionally substituted.